5LTW

Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006611	biological_process	protein export from nucleus
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010482	biological_process	regulation of epidermal cell division
A	0019901	molecular_function	protein kinase binding
A	0022407	biological_process	regulation of cell-cell adhesion
A	0030307	biological_process	positive regulation of cell growth
A	0032880	biological_process	regulation of protein localization
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0045606	biological_process	positive regulation of epidermal cell differentiation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045824	biological_process	negative regulation of innate immune response
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0061436	biological_process	establishment of skin barrier
A	0070062	cellular_component	extracellular exosome
A	0140311	molecular_function	protein sequestering activity
A	0141156	biological_process	cAMP/PKA signal transduction
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
A	1903829	biological_process	positive regulation of protein localization
B	0001836	biological_process	release of cytochrome c from mitochondria
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006611	biological_process	protein export from nucleus
B	0007165	biological_process	signal transduction
B	0008104	biological_process	intracellular protein localization
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0010482	biological_process	regulation of epidermal cell division
B	0019901	molecular_function	protein kinase binding
B	0022407	biological_process	regulation of cell-cell adhesion
B	0030307	biological_process	positive regulation of cell growth
B	0032880	biological_process	regulation of protein localization
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045606	biological_process	positive regulation of epidermal cell differentiation
B	0045785	biological_process	positive regulation of cell adhesion
B	0045824	biological_process	negative regulation of innate immune response
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0050815	molecular_function	phosphoserine residue binding
B	0051219	molecular_function	phosphoprotein binding
B	0061436	biological_process	establishment of skin barrier
B	0070062	cellular_component	extracellular exosome
B	0140311	molecular_function	protein sequestering activity
B	0141156	biological_process	cAMP/PKA signal transduction
B	1903077	biological_process	negative regulation of protein localization to plasma membrane
B	1903829	biological_process	positive regulation of protein localization
C	0005212	molecular_function	structural constituent of eye lens
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0009408	biological_process	response to heat
C	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
C	0016607	cellular_component	nuclear speck
C	0019901	molecular_function	protein kinase binding
C	0042026	biological_process	protein refolding
C	0042803	molecular_function	protein homodimerization activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0044183	molecular_function	protein folding chaperone
C	0045766	biological_process	positive regulation of angiogenesis
C	0051082	molecular_function	unfolded protein binding
C	0051087	molecular_function	protein-folding chaperone binding
D	0005212	molecular_function	structural constituent of eye lens
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0009408	biological_process	response to heat
D	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
D	0016607	cellular_component	nuclear speck
D	0019901	molecular_function	protein kinase binding
D	0042026	biological_process	protein refolding
D	0042803	molecular_function	protein homodimerization activity
D	0043066	biological_process	negative regulation of apoptotic process
D	0044183	molecular_function	protein folding chaperone
D	0045766	biological_process	positive regulation of angiogenesis
D	0051082	molecular_function	unfolded protein binding
D	0051087	molecular_function	protein-folding chaperone binding
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006611	biological_process	protein export from nucleus
E	0007165	biological_process	signal transduction
E	0008104	biological_process	intracellular protein localization
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0010482	biological_process	regulation of epidermal cell division
E	0019901	molecular_function	protein kinase binding
E	0022407	biological_process	regulation of cell-cell adhesion
E	0030307	biological_process	positive regulation of cell growth
E	0032880	biological_process	regulation of protein localization
E	0042802	molecular_function	identical protein binding
E	0045296	molecular_function	cadherin binding
E	0045606	biological_process	positive regulation of epidermal cell differentiation
E	0045785	biological_process	positive regulation of cell adhesion
E	0045824	biological_process	negative regulation of innate immune response
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0050815	molecular_function	phosphoserine residue binding
E	0051219	molecular_function	phosphoprotein binding
E	0061436	biological_process	establishment of skin barrier
E	0070062	cellular_component	extracellular exosome
E	0140311	molecular_function	protein sequestering activity
E	0141156	biological_process	cAMP/PKA signal transduction
E	1903077	biological_process	negative regulation of protein localization to plasma membrane
E	1903829	biological_process	positive regulation of protein localization
F	0001836	biological_process	release of cytochrome c from mitochondria
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006469	biological_process	negative regulation of protein kinase activity
F	0006611	biological_process	protein export from nucleus
F	0007165	biological_process	signal transduction
F	0008104	biological_process	intracellular protein localization
F	0008426	molecular_function	protein kinase C inhibitor activity
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0010482	biological_process	regulation of epidermal cell division
F	0019901	molecular_function	protein kinase binding
F	0022407	biological_process	regulation of cell-cell adhesion
F	0030307	biological_process	positive regulation of cell growth
F	0032880	biological_process	regulation of protein localization
F	0042802	molecular_function	identical protein binding
F	0045296	molecular_function	cadherin binding
F	0045606	biological_process	positive regulation of epidermal cell differentiation
F	0045785	biological_process	positive regulation of cell adhesion
F	0045824	biological_process	negative regulation of innate immune response
F	0046827	biological_process	positive regulation of protein export from nucleus
F	0050815	molecular_function	phosphoserine residue binding
F	0051219	molecular_function	phosphoprotein binding
F	0061436	biological_process	establishment of skin barrier
F	0070062	cellular_component	extracellular exosome
F	0140311	molecular_function	protein sequestering activity
F	0141156	biological_process	cAMP/PKA signal transduction
F	1903077	biological_process	negative regulation of protein localization to plasma membrane
F	1903829	biological_process	positive regulation of protein localization
G	0005212	molecular_function	structural constituent of eye lens
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0009408	biological_process	response to heat
G	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
G	0016607	cellular_component	nuclear speck
G	0019901	molecular_function	protein kinase binding
G	0042026	biological_process	protein refolding
G	0042803	molecular_function	protein homodimerization activity
G	0043066	biological_process	negative regulation of apoptotic process
G	0044183	molecular_function	protein folding chaperone
G	0045766	biological_process	positive regulation of angiogenesis
G	0051082	molecular_function	unfolded protein binding
G	0051087	molecular_function	protein-folding chaperone binding
H	0005212	molecular_function	structural constituent of eye lens
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0009408	biological_process	response to heat
H	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
H	0016607	cellular_component	nuclear speck
H	0019901	molecular_function	protein kinase binding
H	0042026	biological_process	protein refolding
H	0042803	molecular_function	protein homodimerization activity
H	0043066	biological_process	negative regulation of apoptotic process
H	0044183	molecular_function	protein folding chaperone
H	0045766	biological_process	positive regulation of angiogenesis
H	0051082	molecular_function	unfolded protein binding
H	0051087	molecular_function	protein-folding chaperone binding
I	0001836	biological_process	release of cytochrome c from mitochondria
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006469	biological_process	negative regulation of protein kinase activity
I	0006611	biological_process	protein export from nucleus
I	0007165	biological_process	signal transduction
I	0008104	biological_process	intracellular protein localization
I	0008426	molecular_function	protein kinase C inhibitor activity
I	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
I	0010482	biological_process	regulation of epidermal cell division
I	0019901	molecular_function	protein kinase binding
I	0022407	biological_process	regulation of cell-cell adhesion
I	0030307	biological_process	positive regulation of cell growth
I	0032880	biological_process	regulation of protein localization
I	0042802	molecular_function	identical protein binding
I	0045296	molecular_function	cadherin binding
I	0045606	biological_process	positive regulation of epidermal cell differentiation
I	0045785	biological_process	positive regulation of cell adhesion
I	0045824	biological_process	negative regulation of innate immune response
I	0046827	biological_process	positive regulation of protein export from nucleus
I	0050815	molecular_function	phosphoserine residue binding
I	0051219	molecular_function	phosphoprotein binding
I	0061436	biological_process	establishment of skin barrier
I	0070062	cellular_component	extracellular exosome
I	0140311	molecular_function	protein sequestering activity
I	0141156	biological_process	cAMP/PKA signal transduction
I	1903077	biological_process	negative regulation of protein localization to plasma membrane
I	1903829	biological_process	positive regulation of protein localization
J	0001836	biological_process	release of cytochrome c from mitochondria
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006469	biological_process	negative regulation of protein kinase activity
J	0006611	biological_process	protein export from nucleus
J	0007165	biological_process	signal transduction
J	0008104	biological_process	intracellular protein localization
J	0008426	molecular_function	protein kinase C inhibitor activity
J	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
J	0010482	biological_process	regulation of epidermal cell division
J	0019901	molecular_function	protein kinase binding
J	0022407	biological_process	regulation of cell-cell adhesion
J	0030307	biological_process	positive regulation of cell growth
J	0032880	biological_process	regulation of protein localization
J	0042802	molecular_function	identical protein binding
J	0045296	molecular_function	cadherin binding
J	0045606	biological_process	positive regulation of epidermal cell differentiation
J	0045785	biological_process	positive regulation of cell adhesion
J	0045824	biological_process	negative regulation of innate immune response
J	0046827	biological_process	positive regulation of protein export from nucleus
J	0050815	molecular_function	phosphoserine residue binding
J	0051219	molecular_function	phosphoprotein binding
J	0061436	biological_process	establishment of skin barrier
J	0070062	cellular_component	extracellular exosome
J	0140311	molecular_function	protein sequestering activity
J	0141156	biological_process	cAMP/PKA signal transduction
J	1903077	biological_process	negative regulation of protein localization to plasma membrane
J	1903829	biological_process	positive regulation of protein localization
K	0005212	molecular_function	structural constituent of eye lens
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006457	biological_process	protein folding
K	0009408	biological_process	response to heat
K	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
K	0016607	cellular_component	nuclear speck
K	0019901	molecular_function	protein kinase binding
K	0042026	biological_process	protein refolding
K	0042803	molecular_function	protein homodimerization activity
K	0043066	biological_process	negative regulation of apoptotic process
K	0044183	molecular_function	protein folding chaperone
K	0045766	biological_process	positive regulation of angiogenesis
K	0051082	molecular_function	unfolded protein binding
K	0051087	molecular_function	protein-folding chaperone binding
L	0005212	molecular_function	structural constituent of eye lens
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006457	biological_process	protein folding
L	0009408	biological_process	response to heat
L	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
L	0016607	cellular_component	nuclear speck
L	0019901	molecular_function	protein kinase binding
L	0042026	biological_process	protein refolding
L	0042803	molecular_function	protein homodimerization activity
L	0043066	biological_process	negative regulation of apoptotic process
L	0044183	molecular_function	protein folding chaperone
L	0045766	biological_process	positive regulation of angiogenesis
L	0051082	molecular_function	unfolded protein binding
L	0051087	molecular_function	protein-folding chaperone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue TRS A 501

Chain	Residue
A	ASP97
A	LEU131
A	ASP139
A	ILE143

---

site_id	AC2
Number of Residues	4
Details	binding site for residue TRS B 501

Chain	Residue
B	ASP97
B	LEU131
B	ASP139
B	ILE143

---

site_id	AC3
Number of Residues	1
Details	binding site for residue NI D 201

Chain	Residue
D	GLY140

---

site_id	AC4
Number of Residues	4
Details	binding site for residue TRS E 501

Chain	Residue
E	ASP97
E	LEU131
E	ASP139
E	ILE143

---

site_id	AC5
Number of Residues	4
Details	binding site for residue TRS F 501

Chain	Residue
F	ASP97
F	LEU131
F	ASP139
F	ILE143

---

site_id	AC6
Number of Residues	1
Details	binding site for residue NI H 201

Chain	Residue
H	GLY140

---

site_id	AC7
Number of Residues	4
Details	binding site for residue TRS I 501

Chain	Residue
I	ASP97
I	LEU131
I	ASP139
I	ILE143

---

site_id	AC8
Number of Residues	4
Details	binding site for residue TRS J 501

Chain	Residue
J	ASP97
J	LEU131
J	ASP139
J	ILE143

---

site_id	AC9
Number of Residues	3
Details	binding site for residue NI L 201

Chain	Residue
L	SER137
L	PRO138
L	GLY140

---

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"21334344","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Deamidated glutamine","evidences":[{"source":"UniProtKB","id":"P97541","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---