5LQB

Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002366	biological_process	leukocyte activation involved in immune response
A	0002639	biological_process	positive regulation of immunoglobulin production
A	0002903	biological_process	negative regulation of B cell apoptotic process
A	0005125	molecular_function	cytokine activity
A	0005134	molecular_function	interleukin-2 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006366	biological_process	transcription by RNA polymerase II
A	0006955	biological_process	immune response
A	0007155	biological_process	cell adhesion
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007267	biological_process	cell-cell signaling
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0010467	biological_process	gene expression
A	0019209	molecular_function	kinase activator activity
A	0030101	biological_process	natural killer cell activation
A	0030217	biological_process	T cell differentiation
A	0030246	molecular_function	carbohydrate binding
A	0030307	biological_process	positive regulation of cell growth
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031851	molecular_function	kappa-type opioid receptor binding
A	0032729	biological_process	positive regulation of type II interferon production
A	0032740	biological_process	positive regulation of interleukin-17 production
A	0034105	biological_process	positive regulation of tissue remodeling
A	0038110	biological_process	interleukin-2-mediated signaling pathway
A	0042098	biological_process	T cell proliferation
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042104	biological_process	positive regulation of activated T cell proliferation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043208	molecular_function	glycosphingolipid binding
A	0045471	biological_process	response to ethanol
A	0045582	biological_process	positive regulation of T cell differentiation
A	0045591	biological_process	positive regulation of regulatory T cell differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046013	biological_process	regulation of T cell homeostatic proliferation
A	0046651	biological_process	lymphocyte proliferation
A	0048304	biological_process	positive regulation of isotype switching to IgG isotypes
A	0050672	biological_process	negative regulation of lymphocyte proliferation
A	0050728	biological_process	negative regulation of inflammatory response
A	0050729	biological_process	positive regulation of inflammatory response
A	0050798	biological_process	activated T cell proliferation
A	0060999	biological_process	positive regulation of dendritic spine development
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	1900100	biological_process	positive regulation of plasma cell differentiation
A	1901327	biological_process	response to tacrolimus
A	2000320	biological_process	negative regulation of T-helper 17 cell differentiation
A	2000561	biological_process	regulation of CD4-positive, alpha-beta T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR196-HIS202

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site_id	PS00424
Number of Residues	13
Details	INTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL

Chain	Residue	Details
A	THR71-LEU83

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:2793860, ECO:0000269|PubMed:6333684

Chain	Residue	Details
A	THR23

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