5LPK
Crystal structure of the bromodomain of human EP300 bound to the inhibitor XDM1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0004402 | molecular_function | histone acetyltransferase activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0004402 | molecular_function | histone acetyltransferase activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0004402 | molecular_function | histone acetyltransferase activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue XDM A 1201 |
| Chain | Residue |
| A | PRO1074 |
| A | HOH1346 |
| C | LEU1073 |
| A | PHE1075 |
| A | VAL1079 |
| A | TYR1131 |
| A | ASN1132 |
| A | ARG1137 |
| A | EDO1208 |
| A | HOH1304 |
| A | HOH1339 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1202 |
| Chain | Residue |
| A | ARG1067 |
| C | GLN1082 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 1203 |
| Chain | Residue |
| A | ARG1133 |
| A | LYS1134 |
| A | THR1135 |
| A | HOH1312 |
| A | HOH1324 |
| A | HOH1340 |
| B | LYS1134 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1204 |
| Chain | Residue |
| A | ARG1055 |
| A | HOH1318 |
| C | GLN1082 |
| D | GLU1052 |
| D | ASP1107 |
| D | GLY1109 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1205 |
| Chain | Residue |
| A | LYS1134 |
| A | TYR1139 |
| A | HOH1303 |
| B | PG41208 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1206 |
| Chain | Residue |
| A | ASP1069 |
| A | HOH1310 |
| A | HOH1359 |
| C | ARG1137 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1207 |
| Chain | Residue |
| A | ILE1092 |
| A | VAL1093 |
| A | LYS1094 |
| A | SER1095 |
| A | ASN1127 |
| B | GLY1085 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1208 |
| Chain | Residue |
| A | ARG1137 |
| A | XDM1201 |
| A | HOH1329 |
| A | HOH1339 |
| B | ASN1126 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue XDM B 1201 |
| Chain | Residue |
| B | LEU1073 |
| B | PRO1074 |
| B | PHE1075 |
| B | LEU1084 |
| B | ILE1086 |
| B | TYR1131 |
| B | ASN1132 |
| B | ARG1137 |
| B | HOH1319 |
| B | HOH1344 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1202 |
| Chain | Residue |
| A | ASP1119 |
| A | TRP1122 |
| B | SER1136 |
| B | ARG1137 |
| B | VAL1138 |
| B | EDO1203 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1203 |
| Chain | Residue |
| A | TRP1122 |
| B | ASN1132 |
| B | ARG1133 |
| B | SER1136 |
| B | EDO1202 |
| B | HOH1310 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1204 |
| Chain | Residue |
| B | PRO1081 |
| B | ILE1086 |
| B | PRO1087 |
| B | ASP1088 |
| B | TYR1089 |
| B | PHE1090 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1205 |
| Chain | Residue |
| A | TRP1115 |
| A | GLY1161 |
| B | GLU1071 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1206 |
| Chain | Residue |
| B | ARG1067 |
| B | GLN1068 |
| B | ASP1069 |
| B | HOH1313 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1207 |
| Chain | Residue |
| B | GLN1068 |
| B | LYS1144 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue PG4 B 1208 |
| Chain | Residue |
| A | TRP1129 |
| A | TYR1139 |
| A | SER1143 |
| A | EDO1205 |
| B | ILE1092 |
| B | LEU1130 |
| B | TYR1131 |
| B | ARG1133 |
| B | HOH1307 |
| B | HOH1353 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residue XDM C 1201 |
| Chain | Residue |
| C | TYR1131 |
| C | ASN1132 |
| C | ARG1137 |
| C | HOH1306 |
| C | HOH1308 |
| C | HOH1354 |
| A | TYR1066 |
| A | ARG1076 |
| A | GLN1077 |
| C | LEU1073 |
| C | PRO1074 |
| C | VAL1079 |
| C | LEU1084 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 1202 |
| Chain | Residue |
| C | ARG1133 |
| C | LYS1134 |
| C | HOH1334 |
| C | HOH1357 |
| E | ARG1133 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 1203 |
| Chain | Residue |
| C | TYR1139 |
| E | ARG1133 |
| E | LYS1134 |
| E | THR1135 |
| E | SO41203 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue XDM D 1201 |
| Chain | Residue |
| D | PRO1074 |
| D | VAL1079 |
| D | LEU1084 |
| D | ILE1086 |
| D | TYR1131 |
| D | ASN1132 |
| D | ARG1137 |
| D | HOH1305 |
| D | HOH1335 |
| F | LEU1073 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 1203 |
| Chain | Residue |
| D | GLU1071 |
| D | LYS1144 |
| E | TRP1115 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 1204 |
| Chain | Residue |
| A | ARG1104 |
| A | ASP1107 |
| A | THR1108 |
| A | HOH1305 |
| D | ARG1104 |
| D | ASP1107 |
| D | HOH1301 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for residue XDM E 1201 |
| Chain | Residue |
| E | PRO1074 |
| E | VAL1079 |
| E | LEU1084 |
| E | TYR1089 |
| E | TYR1131 |
| E | ASN1132 |
| E | ARG1137 |
| E | VAL1138 |
| E | HOH1301 |
| E | HOH1312 |
| E | HOH1340 |
| G | LEU1073 |
| site_id | AE6 |
| Number of Residues | 11 |
| Details | binding site for residue XDM E 1202 |
| Chain | Residue |
| E | ARG1076 |
| E | GLN1077 |
| E | HOH1334 |
| E | HOH1337 |
| G | PRO1074 |
| G | LEU1084 |
| G | TYR1089 |
| G | TYR1131 |
| G | ASN1132 |
| G | ARG1137 |
| G | HOH1321 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 E 1203 |
| Chain | Residue |
| C | EDO1203 |
| E | ARG1133 |
| E | LYS1134 |
| E | HOH1315 |
| F | ARG1133 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 1204 |
| Chain | Residue |
| E | LYS1140 |
| E | SER1143 |
| E | HOH1322 |
| site_id | AE9 |
| Number of Residues | 12 |
| Details | binding site for residue XDM F 1201 |
| Chain | Residue |
| D | ARG1076 |
| D | GLN1077 |
| D | HOH1342 |
| F | LEU1073 |
| F | PRO1074 |
| F | VAL1079 |
| F | LEU1084 |
| F | TYR1089 |
| F | TYR1131 |
| F | ASN1132 |
| F | ARG1137 |
| F | HOH1304 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 F 1202 |
| Chain | Residue |
| E | LYS1134 |
| E | HOH1307 |
| F | ARG1133 |
| F | LYS1134 |
| F | HOH1316 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 1203 |
| Chain | Residue |
| F | ILE1092 |
| F | VAL1093 |
| F | LYS1094 |
| F | SER1095 |
| F | ASN1127 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO F 1204 |
| Chain | Residue |
| F | TYR1139 |
| site_id | AF4 |
| Number of Residues | 1 |
| Details | binding site for residue EDO G 1201 |
| Chain | Residue |
| G | HOH1333 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVkspMdlstIkrkldtgq..Yqepwqyvddiwl.MfnNAwlY |
| Chain | Residue | Details |
| A | SER1072-TYR1131 |
