5LP7
Crystal structure of 3-Ketoacyl-CoA Thiolase (MmgA) from Bacillus subtilis.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0016746 | molecular_function | acyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| G | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0016746 | molecular_function | acyltransferase activity |
| G | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| H | 0003985 | molecular_function | acetyl-CoA C-acetyltransferase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0016746 | molecular_function | acyltransferase activity |
| H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 401 |
| Chain | Residue |
| E | PHE17 |
| E | GLY249 |
| E | VAL250 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | HOH513 |
| A | HOH558 |
| A | MET157 |
| A | PRO248 |
| A | GLY249 |
| A | ALA319 |
| A | PHE320 |
| A | HIS349 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | LYS25 |
| B | ALA59 |
| B | GLY60 |
| B | SER61 |
| B | ASN120 |
| B | PRO122 |
| B | HOH522 |
| B | HOH594 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | GLN100 |
| B | PHE279 |
| B | HOH512 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 401 |
| Chain | Residue |
| C | ARG93 |
| C | GLN100 |
| C | THR281 |
| C | HOH526 |
| C | HOH529 |
| D | GLU49 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 401 |
| Chain | Residue |
| E | ARG93 |
| E | GLN100 |
| E | HOH573 |
| F | GLU49 |
| F | GLY50 |
| F | PRO80 |
| F | MET101 |
| F | ASP106 |
| F | HOH526 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL G 401 |
| Chain | Residue |
| G | LEU148 |
| G | PRO248 |
| G | GLY249 |
| G | ALA319 |
| G | PHE320 |
| G | HIS349 |
| G | HOH519 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 401 |
| Chain | Residue |
| C | MET101 |
| D | ARG93 |
| D | GLN100 |
| D | PHE279 |
| D | THR281 |
| D | HOH518 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ARG E 222 and ASP E 223 |
| Chain | Residue |
| E | ALA187 |
| E | ILE220 |
| E | ARG221 |
| E | THR224 |
| E | GLN228 |
| E | HOH518 |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. LNKvCASGLrAVtlcdqmI |
| Chain | Residue | Details |
| H | LEU84-ILE102 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GVAAICSGaAqGdA |
| Chain | Residue | Details |
| H | GLY374-ALA387 |
| site_id | PS00737 |
| Number of Residues | 17 |
| Details | THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPiGaSG |
| Chain | Residue | Details |
| H | ASN339-GLY355 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Acyl-thioester intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10020","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
