Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LP3

Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008798	molecular_function	beta-aspartyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0008798	molecular_function	beta-aspartyl-peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0008798	molecular_function	beta-aspartyl-peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0008798	molecular_function	beta-aspartyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0008798	molecular_function	beta-aspartyl-peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0008237	molecular_function	metallopeptidase activity
F	0008270	molecular_function	zinc ion binding
F	0008798	molecular_function	beta-aspartyl-peptidase activity
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0008798	molecular_function	beta-aspartyl-peptidase activity
G	0016787	molecular_function	hydrolase activity
G	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0008237	molecular_function	metallopeptidase activity
H	0008270	molecular_function	zinc ion binding
H	0008798	molecular_function	beta-aspartyl-peptidase activity
H	0016787	molecular_function	hydrolase activity
H	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006508	biological_process	proteolysis
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0008798	molecular_function	beta-aspartyl-peptidase activity
I	0016787	molecular_function	hydrolase activity
I	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006508	biological_process	proteolysis
J	0008237	molecular_function	metallopeptidase activity
J	0008270	molecular_function	zinc ion binding
J	0008798	molecular_function	beta-aspartyl-peptidase activity
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0008798	molecular_function	beta-aspartyl-peptidase activity
K	0016787	molecular_function	hydrolase activity
K	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006508	biological_process	proteolysis
L	0008237	molecular_function	metallopeptidase activity
L	0008270	molecular_function	zinc ion binding
L	0008798	molecular_function	beta-aspartyl-peptidase activity
L	0016787	molecular_function	hydrolase activity
L	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:12946361

Chain	Residue	Details
B	ASP285
J	ASP285
K	ASP285
L	ASP285
C	ASP285
D	ASP285
E	ASP285
A	ASP285
F	ASP285
G	ASP285
H	ASP285
I	ASP285

site_id	SWS_FT_FI2
Number of Residues	60
Details	BINDING: BINDING => ECO:0000269\|PubMed:12718528, ECO:0000269\|PubMed:12946361, ECO:0000269\|PubMed:15882050, ECO:0000269\|PubMed:16289685

Chain	Residue	Details
B	HIS68
C	ASP285
D	HIS68
D	HIS70
D	HIS201
D	HIS230
D	ASP285
E	HIS68
E	HIS70
E	HIS201
E	HIS230
B	HIS70
E	ASP285
A	HIS68
A	HIS70
A	HIS201
A	HIS230
A	ASP285
F	HIS68
F	HIS70
F	HIS201
F	HIS230
B	HIS201
F	ASP285
G	HIS68
G	HIS70
G	HIS201
G	HIS230
G	ASP285
H	HIS68
H	HIS70
H	HIS201
H	HIS230
B	HIS230
H	ASP285
I	HIS68
I	HIS70
I	HIS201
I	HIS230
I	ASP285
J	HIS68
J	HIS70
J	HIS201
J	HIS230
B	ASP285
J	ASP285
K	HIS68
K	HIS70
K	HIS201
K	HIS230
K	ASP285
L	HIS68
L	HIS70
L	HIS201
L	HIS230
C	HIS68
L	ASP285
C	HIS70
C	HIS201
C	HIS230

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
B	GLY75
J	GLY75
K	GLY75
L	GLY75
C	GLY75
D	GLY75
E	GLY75
A	GLY75
F	GLY75
G	GLY75
H	GLY75
I	GLY75

site_id	SWS_FT_FI4
Number of Residues	60
Details	BINDING: BINDING => ECO:0000305\|PubMed:12718528, ECO:0000305\|PubMed:12946361, ECO:0000305\|PubMed:15882050

Chain	Residue	Details
B	THR106
C	SER289
D	THR106
D	TYR137
D	ARG169
D	ARG233
D	SER289
E	THR106
E	TYR137
E	ARG169
E	ARG233
B	TYR137
E	SER289
A	THR106
A	TYR137
A	ARG169
A	ARG233
A	SER289
F	THR106
F	TYR137
F	ARG169
F	ARG233
B	ARG169
F	SER289
G	THR106
G	TYR137
G	ARG169
G	ARG233
G	SER289
H	THR106
H	TYR137
H	ARG169
H	ARG233
B	ARG233
H	SER289
I	THR106
I	TYR137
I	ARG169
I	ARG233
I	SER289
J	THR106
J	TYR137
J	ARG169
J	ARG233
B	SER289
J	SER289
K	THR106
K	TYR137
K	ARG169
K	ARG233
K	SER289
L	THR106
L	TYR137
L	ARG169
L	ARG233
C	THR106
L	SER289
C	TYR137
C	ARG169
C	ARG233

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: via carbamate group => ECO:0000269\|PubMed:12718528, ECO:0000269\|PubMed:12946361, ECO:0000269\|PubMed:15882050, ECO:0000269\|PubMed:16289685

Chain	Residue	Details
B	KCX162
J	KCX162
K	KCX162
L	KCX162
C	KCX162
D	KCX162
E	KCX162
A	KCX162
F	KCX162
G	KCX162
H	KCX162
I	KCX162

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: N6-carboxylysine => ECO:0000269\|PubMed:12718528, ECO:0000269\|PubMed:12946361, ECO:0000269\|PubMed:15882050, ECO:0000269\|PubMed:16289685

Chain	Residue	Details
B	KCX162
J	KCX162
K	KCX162
L	KCX162
C	KCX162
D	KCX162
E	KCX162
A	KCX162
F	KCX162
G	KCX162
H	KCX162
I	KCX162

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
B	HIS68	metal ligand
B	HIS70	metal ligand
B	KCX162	metal ligand
B	HIS201	metal ligand
B	HIS230	metal ligand
B	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA10
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
J	HIS68	metal ligand
J	HIS70	metal ligand
J	KCX162	metal ligand
J	HIS201	metal ligand
J	HIS230	metal ligand
J	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA11
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
K	HIS68	metal ligand
K	HIS70	metal ligand
K	KCX162	metal ligand
K	HIS201	metal ligand
K	HIS230	metal ligand
K	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA12
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
L	HIS68	metal ligand
L	HIS70	metal ligand
L	KCX162	metal ligand
L	HIS201	metal ligand
L	HIS230	metal ligand
L	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
C	HIS68	metal ligand
C	HIS70	metal ligand
C	KCX162	metal ligand
C	HIS201	metal ligand
C	HIS230	metal ligand
C	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
D	HIS68	metal ligand
D	HIS70	metal ligand
D	KCX162	metal ligand
D	HIS201	metal ligand
D	HIS230	metal ligand
D	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
E	HIS68	metal ligand
E	HIS70	metal ligand
E	KCX162	metal ligand
E	HIS201	metal ligand
E	HIS230	metal ligand
E	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
A	HIS68	metal ligand
A	HIS70	metal ligand
A	KCX162	metal ligand
A	HIS201	metal ligand
A	HIS230	metal ligand
A	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
F	HIS68	metal ligand
F	HIS70	metal ligand
F	KCX162	metal ligand
F	HIS201	metal ligand
F	HIS230	metal ligand
F	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA7
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
G	HIS68	metal ligand
G	HIS70	metal ligand
G	KCX162	metal ligand
G	HIS201	metal ligand
G	HIS230	metal ligand
G	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA8
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
H	HIS68	metal ligand
H	HIS70	metal ligand
H	KCX162	metal ligand
H	HIS201	metal ligand
H	HIS230	metal ligand
H	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA9
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
I	HIS68	metal ligand
I	HIS70	metal ligand
I	KCX162	metal ligand
I	HIS201	metal ligand
I	HIS230	metal ligand
I	ASP285	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)