5LP3

Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0008798	molecular_function	beta-aspartyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0008798	molecular_function	beta-aspartyl-peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008237	molecular_function	metallopeptidase activity
C	0008270	molecular_function	zinc ion binding
C	0008798	molecular_function	beta-aspartyl-peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0008798	molecular_function	beta-aspartyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0008233	molecular_function	peptidase activity
E	0008237	molecular_function	metallopeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0008798	molecular_function	beta-aspartyl-peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0008233	molecular_function	peptidase activity
F	0008237	molecular_function	metallopeptidase activity
F	0008270	molecular_function	zinc ion binding
F	0008798	molecular_function	beta-aspartyl-peptidase activity
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0008233	molecular_function	peptidase activity
G	0008237	molecular_function	metallopeptidase activity
G	0008270	molecular_function	zinc ion binding
G	0008798	molecular_function	beta-aspartyl-peptidase activity
G	0016787	molecular_function	hydrolase activity
G	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0008233	molecular_function	peptidase activity
H	0008237	molecular_function	metallopeptidase activity
H	0008270	molecular_function	zinc ion binding
H	0008798	molecular_function	beta-aspartyl-peptidase activity
H	0016787	molecular_function	hydrolase activity
H	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006508	biological_process	proteolysis
I	0008233	molecular_function	peptidase activity
I	0008237	molecular_function	metallopeptidase activity
I	0008270	molecular_function	zinc ion binding
I	0008798	molecular_function	beta-aspartyl-peptidase activity
I	0016787	molecular_function	hydrolase activity
I	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006508	biological_process	proteolysis
J	0008233	molecular_function	peptidase activity
J	0008237	molecular_function	metallopeptidase activity
J	0008270	molecular_function	zinc ion binding
J	0008798	molecular_function	beta-aspartyl-peptidase activity
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0008233	molecular_function	peptidase activity
K	0008237	molecular_function	metallopeptidase activity
K	0008270	molecular_function	zinc ion binding
K	0008798	molecular_function	beta-aspartyl-peptidase activity
K	0016787	molecular_function	hydrolase activity
K	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
K	0042802	molecular_function	identical protein binding
K	0046872	molecular_function	metal ion binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006508	biological_process	proteolysis
L	0008233	molecular_function	peptidase activity
L	0008237	molecular_function	metallopeptidase activity
L	0008270	molecular_function	zinc ion binding
L	0008798	molecular_function	beta-aspartyl-peptidase activity
L	0016787	molecular_function	hydrolase activity
L	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
L	0042802	molecular_function	identical protein binding
L	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
A	HIS68	metal ligand
A	HIS70	metal ligand
A	KCX162	metal ligand
A	SER205	metal ligand
A	ASN234	metal ligand
A	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA10
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
J	HIS68	metal ligand
J	HIS70	metal ligand
J	SER205	metal ligand
J	ASN234	metal ligand
J	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA11
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
K	HIS68	metal ligand
K	HIS70	metal ligand
K	SER205	metal ligand
K	ASN234	metal ligand
K	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA12
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
L	HIS68	metal ligand
L	HIS70	metal ligand
L	SER205	metal ligand
L	ASN234	metal ligand
L	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
B	HIS68	metal ligand
B	HIS70	metal ligand
B	KCX162	metal ligand
B	SER205	metal ligand
B	ASN234	metal ligand
B	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
C	HIS68	metal ligand
C	HIS70	metal ligand
C	KCX162	metal ligand
C	SER205	metal ligand
C	ASN234	metal ligand
C	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
D	HIS68	metal ligand
D	HIS70	metal ligand
D	KCX162	metal ligand
D	SER205	metal ligand
D	ASN234	metal ligand
D	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA5
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
E	HIS68	metal ligand
E	HIS70	metal ligand
E	KCX162	metal ligand
E	SER205	metal ligand
E	ASN234	metal ligand
E	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA6
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
F	HIS68	metal ligand
F	HIS70	metal ligand
F	KCX162	metal ligand
F	SER205	metal ligand
F	ASN234	metal ligand
F	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA7
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
G	HIS68	metal ligand
G	HIS70	metal ligand
G	KCX162	metal ligand
G	SER205	metal ligand
G	ASN234	metal ligand
G	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA8
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
H	HIS68	metal ligand
H	HIS70	metal ligand
H	KCX162	metal ligand
H	SER205	metal ligand
H	ASN234	metal ligand
H	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---

site_id	MCSA9
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
I	HIS68	metal ligand
I	HIS70	metal ligand
I	SER205	metal ligand
I	ASN234	metal ligand
I	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

---