Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LP3

Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0008798	molecular_function	beta-aspartyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0042802	molecular_function	identical protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0008798	molecular_function	beta-aspartyl-peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0042802	molecular_function	identical protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0008798	molecular_function	beta-aspartyl-peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0042802	molecular_function	identical protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008270	molecular_function	zinc ion binding
D	0008798	molecular_function	beta-aspartyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0042802	molecular_function	identical protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008270	molecular_function	zinc ion binding
E	0008798	molecular_function	beta-aspartyl-peptidase activity
E	0016787	molecular_function	hydrolase activity
E	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
E	0042802	molecular_function	identical protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008270	molecular_function	zinc ion binding
F	0008798	molecular_function	beta-aspartyl-peptidase activity
F	0016787	molecular_function	hydrolase activity
F	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
F	0042802	molecular_function	identical protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0008270	molecular_function	zinc ion binding
G	0008798	molecular_function	beta-aspartyl-peptidase activity
G	0016787	molecular_function	hydrolase activity
G	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
G	0042802	molecular_function	identical protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008270	molecular_function	zinc ion binding
H	0008798	molecular_function	beta-aspartyl-peptidase activity
H	0016787	molecular_function	hydrolase activity
H	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
H	0042802	molecular_function	identical protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0008270	molecular_function	zinc ion binding
I	0008798	molecular_function	beta-aspartyl-peptidase activity
I	0016787	molecular_function	hydrolase activity
I	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
I	0042802	molecular_function	identical protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0008270	molecular_function	zinc ion binding
J	0008798	molecular_function	beta-aspartyl-peptidase activity
J	0016787	molecular_function	hydrolase activity
J	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
J	0042802	molecular_function	identical protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0008270	molecular_function	zinc ion binding
K	0008798	molecular_function	beta-aspartyl-peptidase activity
K	0016787	molecular_function	hydrolase activity
K	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
K	0042802	molecular_function	identical protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0008270	molecular_function	zinc ion binding
L	0008798	molecular_function	beta-aspartyl-peptidase activity
L	0016787	molecular_function	hydrolase activity
L	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
L	0042802	molecular_function	identical protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"12718528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12946361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15882050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16289685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
A	HIS68	metal ligand
A	HIS70	metal ligand
A	KCX162	metal ligand
A	SER205	metal ligand
A	ASN234	metal ligand
A	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA10
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
J	HIS68	metal ligand
J	HIS70	metal ligand
J	SER205	metal ligand
J	ASN234	metal ligand
J	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA11
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
K	HIS68	metal ligand
K	HIS70	metal ligand
K	SER205	metal ligand
K	ASN234	metal ligand
K	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA12
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
L	HIS68	metal ligand
L	HIS70	metal ligand
L	SER205	metal ligand
L	ASN234	metal ligand
L	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
B	HIS68	metal ligand
B	HIS70	metal ligand
B	KCX162	metal ligand
B	SER205	metal ligand
B	ASN234	metal ligand
B	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
C	HIS68	metal ligand
C	HIS70	metal ligand
C	KCX162	metal ligand
C	SER205	metal ligand
C	ASN234	metal ligand
C	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
D	HIS68	metal ligand
D	HIS70	metal ligand
D	KCX162	metal ligand
D	SER205	metal ligand
D	ASN234	metal ligand
D	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
E	HIS68	metal ligand
E	HIS70	metal ligand
E	KCX162	metal ligand
E	SER205	metal ligand
E	ASN234	metal ligand
E	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
F	HIS68	metal ligand
F	HIS70	metal ligand
F	KCX162	metal ligand
F	SER205	metal ligand
F	ASN234	metal ligand
F	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA7
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
G	HIS68	metal ligand
G	HIS70	metal ligand
G	KCX162	metal ligand
G	SER205	metal ligand
G	ASN234	metal ligand
G	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA8
Number of Residues	6
Details	M-CSA 172

Chain	Residue	Details
H	HIS68	metal ligand
H	HIS70	metal ligand
H	KCX162	metal ligand
H	SER205	metal ligand
H	ASN234	metal ligand
H	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

site_id	MCSA9
Number of Residues	5
Details	M-CSA 172

Chain	Residue	Details
I	HIS68	metal ligand
I	HIS70	metal ligand
I	SER205	metal ligand
I	ASN234	metal ligand
I	SER289	hydrogen bond acceptor, hydrogen bond donor, metal ligand, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)