5LNK

Entire ovine respiratory complex I

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0010181	molecular_function	FMN binding
1	0051287	molecular_function	NAD binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
2	0016491	molecular_function	oxidoreductase activity
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0016491	molecular_function	oxidoreductase activity
3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
3	0042773	biological_process	ATP synthesis coupled electron transport
3	0051536	molecular_function	iron-sulfur cluster binding
4	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4	0048038	molecular_function	quinone binding
4	0051287	molecular_function	NAD binding
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0048038	molecular_function	quinone binding
6	0051536	molecular_function	iron-sulfur cluster binding
6	0051539	molecular_function	4 iron, 4 sulfur cluster binding
9	0016020	cellular_component	membrane
9	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
9	0051539	molecular_function	4 iron, 4 sulfur cluster binding
a	0005739	cellular_component	mitochondrion
a	0045271	cellular_component	respiratory chain complex I
A	0005743	cellular_component	mitochondrial inner membrane
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0022904	biological_process	respiratory electron transport chain
A	0030964	cellular_component	NADH dehydrogenase complex
A	0045271	cellular_component	respiratory chain complex I
A	1902600	biological_process	proton transmembrane transport
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
c	0022900	biological_process	electron transport chain
f	0022904	biological_process	respiratory electron transport chain
g	0045271	cellular_component	respiratory chain complex I
h	0005743	cellular_component	mitochondrial inner membrane
h	0042773	biological_process	ATP synthesis coupled electron transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0022904	biological_process	respiratory electron transport chain
H	0031966	cellular_component	mitochondrial membrane
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
i	0016020	cellular_component	membrane
i	0045271	cellular_component	respiratory chain complex I
j	0006633	biological_process	fatty acid biosynthetic process
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0022904	biological_process	respiratory electron transport chain
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
k	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
K	0005743	cellular_component	mitochondrial inner membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0022904	biological_process	respiratory electron transport chain
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0045271	cellular_component	respiratory chain complex I
K	1902600	biological_process	proton transmembrane transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005743	cellular_component	mitochondrial inner membrane
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0015990	biological_process	electron transport coupled proton transport
L	0022904	biological_process	respiratory electron transport chain
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0045271	cellular_component	respiratory chain complex I
m	0005743	cellular_component	mitochondrial inner membrane
m	0045271	cellular_component	respiratory chain complex I
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0022904	biological_process	respiratory electron transport chain
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0045271	cellular_component	respiratory chain complex I
M	0048039	molecular_function	ubiquinone binding
n	0005739	cellular_component	mitochondrion
n	0022900	biological_process	electron transport chain
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0022904	biological_process	respiratory electron transport chain
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0045271	cellular_component	respiratory chain complex I
N	1902600	biological_process	proton transmembrane transport
o	0005743	cellular_component	mitochondrial inner membrane
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0005739	cellular_component	mitochondrion
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005743	cellular_component	mitochondrial inner membrane
q	0006915	biological_process	apoptotic process
q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
q	0022904	biological_process	respiratory electron transport chain
q	0045271	cellular_component	respiratory chain complex I
q	0045892	biological_process	negative regulation of DNA-templated transcription
q	1902600	biological_process	proton transmembrane transport
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
s	0005739	cellular_component	mitochondrion
t	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0005743	cellular_component	mitochondrial inner membrane
u	0045271	cellular_component	respiratory chain complex I
v	0005739	cellular_component	mitochondrion
v	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
x	0005739	cellular_component	mitochondrion
x	0045271	cellular_component	respiratory chain complex I
X	0006633	biological_process	fatty acid biosynthetic process
y	0005739	cellular_component	mitochondrion
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0022904	biological_process	respiratory electron transport chain
z	0045271	cellular_component	respiratory chain complex I

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SF4 1 500

Chain	Residue
1	PRO203
1	SER358
1	CYS359
1	GLN361
1	CYS362
1	CYS365
1	THR403
1	ILE404
1	CYS405

---

site_id	AC2
Number of Residues	17
Details	binding site for residue FMN 1 501

Chain	Residue
1	GLY67
1	ARG68
1	ALA71
1	LYS78
1	ASN96
1	ASP98
1	GLU99
1	GLY100
1	TYR184
1	GLY187
1	GLU188
1	GLU189
1	VAL222
1	ALA223
1	ASN224
1	THR227
1	ALA406

---

site_id	AC3
Number of Residues	11
Details	binding site for residue FES 2 300

Chain	Residue
1	PRO102
1	GLY103
2	CYS103
2	PRO107
2	CYS108
2	CYS144
2	LEU145
2	GLY146
2	ALA147
2	CYS148
2	MET153

---

site_id	AC4
Number of Residues	10
Details	binding site for residue SF4 3 801

Chain	Residue
3	HIS101
3	ASP104
3	CYS105
3	CYS108
3	CYS114
3	GLN117
3	ARG152
3	VAL205
3	GLY206
4	MET342

---

site_id	AC5
Number of Residues	9
Details	binding site for residue SF4 3 802

Chain	Residue
3	CYS153
3	ILE154
3	GLN155
3	CYS156
3	THR157
3	CYS159
3	CYS203
3	PRO204
3	VAL205

---

site_id	AC6
Number of Residues	8
Details	binding site for residue FES 3 803

Chain	Residue
3	CYS41
3	TYR42
3	ALA49
3	GLY50
3	CYS52
3	ARG53
3	CYS55
3	CYS69

---

site_id	AC7
Number of Residues	9
Details	binding site for residue SF4 6 300

Chain	Residue
4	ARG105
4	HIS190
6	CYS54
6	CYS55
6	GLY90
6	SER118
6	CYS119
6	CYS149
6	PRO150

---

site_id	AC8
Number of Residues	14
Details	binding site for residue 3PE 9 501

Chain	Residue
4	ARG233
4	ASN237
9	THR24
9	LEU25
9	TRP27
9	LEU30
9	ILE31
H	PRO180
H	PHE186
H	ILE187
H	ASN292
H	LEU296
m	VAL17
q	ILE39

---

site_id	AC9
Number of Residues	10
Details	binding site for residue SF4 9 502

Chain	Residue
9	HIS65
9	CYS87
9	PRO88
9	ILE92
9	CYS116
9	ILE117
9	TYR118
9	CYS119
9	GLY120
9	CYS122

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SF4 9 503

Chain	Residue
9	ALA79
9	CYS80
9	LYS81
9	CYS83
9	CYS126
9	ALA130
9	CYS77
9	ILE78

---

site_id	AD2
Number of Residues	11
Details	binding site for residue PC1 N 401

Chain	Residue
N	SER125
N	LEU128
N	THR132
N	ILE206
N	SER213
N	MET220
N	THR324
N	MET329
k	PRO5
o	PC1201
o	3PE203

---

site_id	AD3
Number of Residues	8
Details	binding site for residue PC1 A 200

Chain	Residue
A	PHE96
A	ALA99
A	ALA103
A	TYR104
A	GLN108
J	TRP159
N	ILE4
m	PHE22

---

site_id	AD4
Number of Residues	9
Details	binding site for residue PC1 M 501

Chain	Residue
M	LEU2
M	THR55
M	LEU101
M	PHE105
M	MET121
N	PRO256
N	MET335
N	PRO338
Y	THR170

---

site_id	AD5
Number of Residues	12
Details	binding site for residue CDL M 502

Chain	Residue
L	ASN23
L	TRP66
L	CDL601
M	LEU446
M	LEU449
M	ASN450
W	LEU30
W	VAL37
W	HIS69
w	SER74
w	VAL77
w	ALA78

---

site_id	AD6
Number of Residues	15
Details	binding site for residue CDL L 601

Chain	Residue
L	LEU15
L	ILE22
L	GLN116
L	LYS119
L	TYR120
L	LEU123
L	THR127
L	MET150
M	ALA357
M	LEU360
M	LEU369
M	PRO371
M	LEU445
M	CDL502
W	LEU22

---

site_id	AD7
Number of Residues	10
Details	binding site for residue CDL J 300

Chain	Residue
A	THR89
A	MET90
J	THR151
J	TRP152
J	TRP159
N	LEU15
N	ILE18
l	VAL11
l	LEU13
o	PC1201

---

site_id	AD8
Number of Residues	15
Details	binding site for residue 3PE J 301

Chain	Residue
A	LEU3
A	LEU7
H	LEU81
H	MET98
H	ASN99
H	PHE104
J	ILE34
J	VAL35
J	GLY38
J	GLY42
J	LEU45
J	SER50
J	LEU54
J	PHE57
q	PHE139

---

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN b 300

Chain	Residue
b	CYS59
b	HIS68
b	CYS84
b	CYS87

---

site_id	AE1
Number of Residues	17
Details	binding site for residue NDP d 401

Chain	Residue
6	ARG178
d	GLY25
d	THR27
d	GLY28
d	PHE29
d	LEU30
d	ARG50
d	GLU52
d	VAL95
d	GLY96
d	ARG97
d	GLU98
d	PHE104
d	ILE132
d	HIS134
d	ALA169
d	ILE171

---

site_id	AE2
Number of Residues	13
Details	binding site for residue CDL i 201

Chain	Residue
H	TYR43
h	SER2
h	ALA3
h	THR4
h	ILE7
i	LEU3
i	VAL6
i	LEU7
i	ARG9
i	GLN13
i	TYR23
z	PHE3
z	LEU6

---

site_id	AE3
Number of Residues	12
Details	binding site for residue ZMP j 101

Chain	Residue
g	LYS28
g	VAL31
g	LEU34
g	TRP38
g	MET65
g	PHE66
g	ASN69
g	ALA70
g	VAL78
g	PHE105
j	ASP43
j	SER44

---

site_id	AE4
Number of Residues	12
Details	binding site for residue PC1 o 201

Chain	Residue
J	CDL300
N	ILE18
N	MET21
N	LEU346
N	PC1401
l	PRO1
l	PHE2
l	PHE3
o	LEU11
o	GLN12
o	PHE13
o	ARG78

---

site_id	AE5
Number of Residues	11
Details	binding site for residue 3PE o 202

Chain	Residue
M	MET9
M	MET10
M	TRP16
M	LEU17
M	ALA90
N	ILE239
o	PHE36
o	TYR39
o	LEU43
o	VAL53
o	LEU54

---

site_id	AE6
Number of Residues	8
Details	binding site for residue 3PE o 203

Chain	Residue
N	THR324
N	LEU325
N	LEU332
N	PC1401
o	ARG60
o	LEU63
o	TYR64
o	PHE68

---

site_id	AE7
Number of Residues	9
Details	binding site for residue PNS X 401

Chain	Residue
X	ASP43
X	SER44
X	LEU45
t	GLN12
t	VAL15
t	HIS50
t	LYS51
t	ALA59
t	LEU63

---

Functional Information from PROSITE/UniProt

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
3	PRO38-CYS55

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
3	CYS105-GLN117

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
3	ARG152-PHE162

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
9	CYS77-PRO88
9	CYS116-PRO127

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
4	LEU83-LYS94

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
H	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
H	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
2	ASP134-PRO152

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
6	GLY135-PRO151

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
5	GLU131-LEU152

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
1	GLY180-SER195

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
1	GLU357-GLY368

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
X	ASP39-MET54

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
X	ASP64-ILE76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Hydroxyarginine","evidences":[{"source":"PubMed","id":"23836892","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1161
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P56181","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---