Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007163 | biological_process | establishment or maintenance of cell polarity |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007163 | biological_process | establishment or maintenance of cell polarity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue ADP A 601 |
Chain | Residue |
A | GLY261 |
A | GLU333 |
A | VAL335 |
A | ASP339 |
A | ASP382 |
A | ASN383 |
A | LEU385 |
A | THR395 |
A | ASP396 |
A | PHE552 |
A | MN603 |
A | GLY263 |
A | MN604 |
A | AF3605 |
F | ARG8 |
A | SER264 |
A | TYR265 |
A | ALA266 |
A | VAL268 |
A | ALA281 |
A | LYS283 |
A | ILE332 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue AF3 A 602 |
Chain | Residue |
A | ARG377 |
A | GLY415 |
A | THR416 |
A | TYR419 |
A | ILE420 |
A | ALA421 |
A | ILE424 |
A | VAL434 |
A | ALA438 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue MN A 603 |
Chain | Residue |
A | ASN383 |
A | ASP396 |
A | ADP601 |
A | AF3605 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue MN A 604 |
Chain | Residue |
A | ASP396 |
A | ADP601 |
A | AF3605 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue AF3 A 605 |
Chain | Residue |
A | SER264 |
A | LYS380 |
A | ASN383 |
A | ASP396 |
A | ADP601 |
A | MN603 |
A | MN604 |
F | GLY10 |
F | SER11 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue SCN A 606 |
Chain | Residue |
A | GLU288 |
A | PRO565 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue MN A 607 |
Chain | Residue |
A | HIS354 |
B | HIS354 |
site_id | AC8 |
Number of Residues | 20 |
Details | binding site for residue ADP B 601 |
Chain | Residue |
B | GLY263 |
B | SER264 |
B | TYR265 |
B | ALA266 |
B | VAL268 |
B | LYS283 |
B | ILE332 |
B | GLU333 |
B | VAL335 |
B | ASP339 |
B | ASP382 |
B | ASN383 |
B | LEU385 |
B | THR395 |
B | ASP396 |
B | PHE552 |
B | MN603 |
B | MN604 |
B | AF3605 |
G | ARG8 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue AF3 B 602 |
Chain | Residue |
B | ARG377 |
B | ASP378 |
B | TYR419 |
B | ILE424 |
B | VAL434 |
B | ASP435 |
B | ALA438 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MN B 603 |
Chain | Residue |
B | LYS380 |
B | ASN383 |
B | ASP396 |
B | ADP601 |
B | AF3605 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue MN B 604 |
Chain | Residue |
B | ASP396 |
B | ADP601 |
B | AF3605 |
B | HOH705 |
site_id | AD3 |
Number of Residues | 11 |
Details | binding site for residue AF3 B 605 |
Chain | Residue |
B | GLY263 |
B | SER264 |
B | TYR265 |
B | LYS380 |
B | ASN383 |
B | ASP396 |
B | ADP601 |
B | MN603 |
B | MN604 |
G | GLY10 |
G | SER11 |
site_id | AD4 |
Number of Residues | 1 |
Details | binding site for residue SCN B 606 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 28 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGSYAKVLlVrlkktdriyamk......VVKK |
Chain | Residue | Details |
A | ILE260-LYS287 | |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKldNVLL |
Chain | Residue | Details |
A | ILE374-LEU386 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP378 | |
B | ASP378 | |
Chain | Residue | Details |
A | ILE260 | |
A | LYS283 | |
B | ILE260 | |
B | LYS283 | |
Chain | Residue | Details |
A | TYR265 | |
B | TYR265 | |
Chain | Residue | Details |
A | TYR280 | |
A | TYR334 | |
B | TYR280 | |
B | TYR334 | |
Chain | Residue | Details |
A | TPO412 | |
B | TPO412 | |
Chain | Residue | Details |
A | TPO564 | |
B | TPO564 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 756 |
Chain | Residue | Details |
A | ASP378 | proton shuttle (general acid/base) |
A | LYS380 | electrostatic stabiliser |
A | ASN383 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 756 |
Chain | Residue | Details |
B | ASP378 | proton shuttle (general acid/base) |
B | LYS380 | electrostatic stabiliser |
B | ASN383 | electrostatic stabiliser |