5LGS

Crystal structure of mouse CARM1 in complex with ligand P2C3u

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 501

Chain	Residue
A	ASN444
A	LYS445
A	HOH618
A	HOH673
B	ARG209

---

site_id	AC2
Number of Residues	1
Details	binding site for residue DXE A 502

Chain	Residue
A	GLY398

---

site_id	AC3
Number of Residues	1
Details	binding site for residue DXE B 501

Chain	Residue
B	ASP393

---

site_id	AC4
Number of Residues	4
Details	binding site for residue PG4 B 502

Chain	Residue
B	GLU244
B	GLU245
A	LYS463
B	SER136

---

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO C 501

Chain	Residue
C	TRP404

---

site_id	AC6
Number of Residues	1
Details	binding site for residue EDO C 502

Chain	Residue
C	GLN205

---

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO D 501

Chain	Residue
D	ASP393

---

site_id	AC8
Number of Residues	3
Details	binding site for residue DXE D 502

Chain	Residue
A	LEU178
A	GLN205
D	GLY461

---

site_id	AC9
Number of Residues	25
Details	binding site for Di-peptide QVR E 1001 and ARG E 1

Chain	Residue
A	TYR150
A	PHE151
A	TYR154
A	MET163
A	GLY193
A	GLU215
A	ALA216
A	GLY241
A	LYS242
A	VAL243
A	GLU244
A	GLU258
A	MET260
A	GLU267
A	MET269
A	SER272
A	HIS415
A	HOH642
E	ALA-1
E	PRO0
E	PRO2
E	PRO3
E	HOH1103
E	HOH1104
E	HOH1105

---

site_id	AD1
Number of Residues	25
Details	binding site for Di-peptide QVR F 1001 and ARG F 1

Chain	Residue
B	TYR150
B	PHE151
B	TYR154
B	MET163
B	GLY193
B	GLU215
B	ALA216
B	GLY241
B	LYS242
B	VAL243
B	GLU244
B	GLU258
B	MET260
B	GLU267
B	MET269
B	SER272
B	HIS415
B	HOH671
F	ALA-1
F	PRO0
F	PRO2
F	PRO3
F	HOH1103
F	HOH1104
F	HOH1106

---

site_id	AD2
Number of Residues	22
Details	binding site for Di-peptide QVR G 101 and ARG G 1

Chain	Residue
C	TYR150
C	PHE151
C	TYR154
C	MET163
C	GLY193
C	GLU215
C	ALA216
C	LYS242
C	VAL243
C	GLU244
C	GLU258
C	MET260
C	GLU267
C	MET269
C	SER272
C	HIS415
C	HOH628
G	ALA-1
G	PRO0
G	PRO2
G	PRO3
G	HOH201

---

site_id	AD3
Number of Residues	22
Details	binding site for Di-peptide QVR H 101 and ARG H 1

Chain	Residue
D	MET260
D	GLU267
D	MET269
D	SER272
D	HIS415
H	ALA-1
H	PRO0
H	PRO2
H	PRO3
H	HOH202
H	HOH203
H	HOH204
D	TYR150
D	TYR154
D	MET163
D	GLY193
D	GLU215
D	ALA216
D	LYS242
D	VAL243
D	GLU244
D	GLU258

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Omega-N-methylated arginine; by CARM1; partial => ECO:0000305|PubMed:11850402

Chain	Residue	Details
E	ARG1
B	GLU215
B	GLU244
B	SER272
C	GLN160
C	ARG169
C	GLY193
C	GLU215
C	GLU244
C	SER272
D	GLN160
F	ARG1
D	ARG169
D	GLY193
D	GLU215
D	GLU244
D	SER272
G	ARG1
H	ARG1
A	GLU244
A	SER272
B	GLN160
B	ARG169
B	GLY193

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:19843527

Chain	Residue	Details
A	SER217
B	SER217
C	SER217
D	SER217

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q86X55

Chain	Residue	Details
A	LYS228
B	LYS228
C	LYS228
D	LYS228

---