5LC0
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0044423 | cellular_component | virion component |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0044423 | cellular_component | virion component |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue 6T8 A 1201 |
| Chain | Residue |
| A | SER81 |
| A | SER1135 |
| A | GLY1151 |
| A | ASN1152 |
| A | GLY1153 |
| A | VAL1155 |
| A | TYR1161 |
| B | VAL1036 |
| B | HIS1051 |
| B | LYS1054 |
| A | GLY82 |
| A | ASP83 |
| A | VAL1036 |
| A | HIS1051 |
| A | ASP1129 |
| A | TYR1130 |
| A | ALA1132 |
| A | GLY1133 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue 6T8 B 1201 |
| Chain | Residue |
| A | HIS1051 |
| A | LYS1054 |
| B | SER81 |
| B | GLY82 |
| B | ASP83 |
| B | VAL1036 |
| B | HIS1051 |
| B | ASP1075 |
| B | ASP1129 |
| B | TYR1130 |
| B | ALA1132 |
| B | GLY1133 |
| B | SER1135 |
| B | GLY1151 |
| B | ASN1152 |
| B | GLY1153 |
| B | VAL1154 |
| B | VAL1155 |
| B | TYR1161 |
| B | HOH1301 |
