5LBC
HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | UN9503 |
| A | HOH618 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 502 |
| Chain | Residue |
| A | LYS204 |
| A | HIS205 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue UN9 A 503 |
| Chain | Residue |
| A | MET299 |
| A | TYR303 |
| A | TYR310 |
| A | HIS313 |
| A | ASP315 |
| A | TYR329 |
| A | LEU343 |
| A | HIS374 |
| A | VAL376 |
| A | ARG383 |
| A | ARG398 |
| A | MN501 |
| A | HOH618 |
| A | HOH622 |
| A | ASP254 |
| A | ILE256 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | ARG396 |
| A | ARG411 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | ASP355 |
| A | ILE356 |
| A | GLU357 |
| A | LYS359 |
| A | ARG362 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | TYR310 |
| A | GLU375 |
| A | VAL376 |
| A | PRO378 |
| A | HOH676 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | LYS332 |
| A | ASP333 |
| A | PHE360 |
| A | HOH602 |
| A | HOH607 |
| A | HOH663 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue BCT A 508 |
| Chain | Residue |
| A | LYS262 |
| A | ARG312 |
| A | VAL314 |
| A | PRO373 |
| A | HOH604 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 101 |
| Details | Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Beta(2)beta(3) 'finger-like' loop","evidences":[{"source":"PubMed","id":"18063574","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
