5LB8

Crystal structure of human RECQL5 helicase APO form.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006310	biological_process	DNA recombination
D	0003676	molecular_function	nucleic acid binding
D	0004386	molecular_function	helicase activity
D	0005524	molecular_function	ATP binding
D	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 601

Chain	Residue
A	CYS411
A	CYS431
A	CYS434

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN D 601

Chain	Residue
D	CYS411
D	CYS427
D	CYS431
D	CYS434

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Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SyLVVDEAHC

Chain	Residue	Details
A	SER152-CYS161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000305|PubMed:28100692, ECO:0007744|PDB:5LB3, ECO:0007744|PDB:5LB5, ECO:0007744|PDB:5LBA

Chain	Residue	Details
A	LYS30
A	GLN34
A	GLY55
A	ALA56
A	GLY57
A	LYS58
A	SER59
D	PHE26
D	SER28
D	LYS30
D	GLN34
D	GLY55
D	ALA56
D	GLY57
D	LYS58
D	SER59
A	PHE26
A	SER28

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:5LB5

Chain	Residue	Details
D	PRO53
A	PRO53

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:28100692, ECO:0007744|PDB:5LB3, ECO:0007744|PDB:5LB5, ECO:0007744|PDB:5LB8, ECO:0007744|PDB:5LBA

Chain	Residue	Details
A	CYS434
D	CYS411
D	CYS431
D	CYS434
A	CYS411
A	CYS431

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:28100692, ECO:0007744|PDB:5LB3, ECO:0007744|PDB:5LB5, ECO:0007744|PDB:5LBA

Chain	Residue	Details
A	CYS427
D	CYS427

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:D4ACP5

Chain	Residue	Details
A	SER488
D	SER488

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER491
D	SER491

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