5LB3

Crystal structure of human RECQL5 helicase in complex with ADP/Mg.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003676	molecular_function	nucleic acid binding
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006310	biological_process	DNA recombination
E	0003676	molecular_function	nucleic acid binding
E	0004386	molecular_function	helicase activity
E	0005524	molecular_function	ATP binding
E	0006310	biological_process	DNA recombination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	CYS411
B	CYS427
B	CYS431
B	CYS434

---

site_id	AC2
Number of Residues	23
Details	binding site for residue ADP B 502

Chain	Residue
B	PRO53
B	THR54
B	GLY55
B	ALA56
B	GLY57
B	LYS58
B	SER59
B	LEU60
B	MG503
B	HOH627
B	HOH631
B	HOH650
B	HOH656
B	HOH694
B	HOH742
B	HOH770
B	HOH788
B	HOH799
B	PHE26
B	SER28
B	PHE29
B	LYS30
B	GLN34

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG B 503

Chain	Residue
B	ADP502
B	HOH631
B	HOH656
B	HOH662
B	HOH770
B	HOH824

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS411
E	CYS427
E	CYS431
E	CYS434

---

site_id	AC5
Number of Residues	22
Details	binding site for residue ADP E 502

Chain	Residue
E	PHE26
E	SER28
E	PHE29
E	LYS30
E	GLN34
E	PRO53
E	THR54
E	GLY55
E	ALA56
E	GLY57
E	LYS58
E	SER59
E	LEU60
E	MG503
E	HOH603
E	HOH606
E	HOH635
E	HOH678
E	HOH680
E	HOH690
E	HOH696
E	HOH752

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG E 503

Chain	Residue
E	ADP502
E	HOH635
E	HOH680
E	HOH752
E	HOH827

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SyLVVDEAHC

Chain	Residue	Details
B	SER152-CYS161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	348
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28100692","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5LB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5LB5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28100692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LB8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28100692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LB5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LBA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---