5L9R

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalylglycine (NOG)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	OGA502
A	HOH650

---

site_id	AC2
Number of Residues	15
Details	binding site for residue OGA A 502

Chain	Residue
A	TYR329
A	LEU343
A	HIS374
A	VAL376
A	ARG383
A	MN501
A	HOH613
A	HOH622
A	HOH626
A	HOH647
A	HOH650
A	MET299
A	TYR310
A	HIS313
A	ASP315

---

site_id	AC3
Number of Residues	8
Details	binding site for residue OGA A 503

Chain	Residue
A	VAL209
A	ASP355
A	ILE356
A	ARG362
A	HOH603
A	HOH620
A	HOH641
A	HOH675

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PG4 A 504

Chain	Residue
A	GLY294
A	ARG295
A	SO4507
A	HOH652
A	HOH699

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG312
A	HIS313
A	VAL314
A	PRO373
A	HOH602
A	HOH667

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 506

Chain	Residue
A	ILE292
A	HOH609
A	HOH692

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 A 507

Chain	Residue
A	ARG322
A	PG4504

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL A 508

Chain	Residue
A	ARG252
A	GLY253
A	GLY309
A	TYR310
A	HOH610

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	101
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Beta(2)beta(3) 'finger-like' loop","evidences":[{"source":"PubMed","id":"18063574","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---