5L6E
Crystal structure of the human METTL3-METTL14 complex bound to SAM
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue SAM A 601 |
Chain | Residue |
A | CYS376 |
A | LYS513 |
A | PHE534 |
A | ARG536 |
A | HIS538 |
A | ASN539 |
A | ASN549 |
A | GLN550 |
A | HOH712 |
A | HOH744 |
A | HOH778 |
A | ASP377 |
A | HOH805 |
A | ILE378 |
A | ASP395 |
A | PRO397 |
A | GLY407 |
A | LEU409 |
A | SER511 |
A | HIS512 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 602 |
Chain | Residue |
A | ASP552 |
A | HOH708 |
A | HOH803 |
A | HOH829 |
A | HOH832 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue ACT B 401 |
Chain | Residue |
A | GLU438 |
B | ARG249 |
B | ARG254 |
B | ARG255 |
B | HOH507 |
B | HOH602 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
Chain | Residue | Details |
B | TYR146 | |
B | ASP242 | |
B | ARG245 | |
B | ARG298 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:27373337, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PDB:5K7U, ECO:0007744|PDB:5K7W |
Chain | Residue | Details |
A | ASP395 | |
A | LYS513 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
Chain | Residue | Details |
A | GLU438 | |
A | ARG441 |