5L1D

Structure of rabbit RyR2 in complex with FKBP12.6 in a closed state (conformation C1)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005102	molecular_function	signaling receptor binding
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005528	molecular_function	FK506 binding
B	0005737	cellular_component	cytoplasm
B	0006457	biological_process	protein folding
B	0006458	biological_process	'de novo' protein folding
B	0010459	biological_process	negative regulation of heart rate
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0016853	molecular_function	isomerase activity
B	0019722	biological_process	calcium-mediated signaling
B	0019855	molecular_function	calcium channel inhibitor activity
B	0030018	cellular_component	Z disc
B	0033017	cellular_component	sarcoplasmic reticulum membrane
B	0034704	cellular_component	calcium channel complex
B	0042026	biological_process	protein refolding
B	0044325	molecular_function	transmembrane transporter binding
B	0050849	biological_process	negative regulation of calcium-mediated signaling
B	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
B	0051604	biological_process	protein maturation
B	0051775	biological_process	response to redox state
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0005102	molecular_function	signaling receptor binding
D	0005246	molecular_function	calcium channel regulator activity
D	0005515	molecular_function	protein binding
D	0005528	molecular_function	FK506 binding
D	0005737	cellular_component	cytoplasm
D	0006457	biological_process	protein folding
D	0006458	biological_process	'de novo' protein folding
D	0010459	biological_process	negative regulation of heart rate
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0016853	molecular_function	isomerase activity
D	0019722	biological_process	calcium-mediated signaling
D	0019855	molecular_function	calcium channel inhibitor activity
D	0030018	cellular_component	Z disc
D	0033017	cellular_component	sarcoplasmic reticulum membrane
D	0034704	cellular_component	calcium channel complex
D	0042026	biological_process	protein refolding
D	0044325	molecular_function	transmembrane transporter binding
D	0050849	biological_process	negative regulation of calcium-mediated signaling
D	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
D	0051604	biological_process	protein maturation
D	0051775	biological_process	response to redox state
D	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
E	0005262	molecular_function	calcium channel activity
E	0005509	molecular_function	calcium ion binding
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0016020	cellular_component	membrane
E	0055085	biological_process	transmembrane transport
E	0070588	biological_process	calcium ion transmembrane transport
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005246	molecular_function	calcium channel regulator activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006457	biological_process	protein folding
F	0006458	biological_process	'de novo' protein folding
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0016853	molecular_function	isomerase activity
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0030018	cellular_component	Z disc
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034704	cellular_component	calcium channel complex
F	0042026	biological_process	protein refolding
F	0044325	molecular_function	transmembrane transporter binding
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051604	biological_process	protein maturation
F	0051775	biological_process	response to redox state
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005219	molecular_function	ryanodine-sensitive calcium-release channel activity
G	0005262	molecular_function	calcium channel activity
G	0005509	molecular_function	calcium ion binding
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0006874	biological_process	intracellular calcium ion homeostasis
G	0016020	cellular_component	membrane
G	0055085	biological_process	transmembrane transport
G	0070588	biological_process	calcium ion transmembrane transport
H	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
H	0005102	molecular_function	signaling receptor binding
H	0005246	molecular_function	calcium channel regulator activity
H	0005515	molecular_function	protein binding
H	0005528	molecular_function	FK506 binding
H	0005737	cellular_component	cytoplasm
H	0006457	biological_process	protein folding
H	0006458	biological_process	'de novo' protein folding
H	0010459	biological_process	negative regulation of heart rate
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016529	cellular_component	sarcoplasmic reticulum
H	0016853	molecular_function	isomerase activity
H	0019722	biological_process	calcium-mediated signaling
H	0019855	molecular_function	calcium channel inhibitor activity
H	0030018	cellular_component	Z disc
H	0033017	cellular_component	sarcoplasmic reticulum membrane
H	0034704	cellular_component	calcium channel complex
H	0042026	biological_process	protein refolding
H	0044325	molecular_function	transmembrane transporter binding
H	0050849	biological_process	negative regulation of calcium-mediated signaling
H	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
H	0051604	biological_process	protein maturation
H	0051775	biological_process	response to redox state
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	352
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---