Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
B | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue GOL B 601 |
Chain | Residue |
B | VAL370 |
B | GLU495 |
B | HOH749 |
B | HOH881 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue GOL B 602 |
Chain | Residue |
B | HOH740 |
B | HOH763 |
B | HOH889 |
C | ARG72 |
B | TRP285 |
B | GLU298 |
B | HOH701 |
B | HOH704 |
B | HOH731 |
Functional Information from PROSITE/UniProt
site_id | PS00299 |
Number of Residues | 26 |
Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
Chain | Residue | Details |
C | LYS27-ASP52 | |
site_id | PS00972 |
Number of Residues | 16 |
Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLknqGAtCYMNSlLQ |
Chain | Residue | Details |
B | GLY215-GLN230 | |
site_id | PS00973 |
Number of Residues | 18 |
Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YiLhAVlvHsGdnhg..GHY |
Chain | Residue | Details |
B | TYR448-TYR465 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Interacts with activating enzyme |
Chain | Residue | Details |
C | ARG54 | |
C | ARG72 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Essential for function |
Chain | Residue | Details |
C | HIS68 | |
Chain | Residue | Details |
C | SER65 | |
Chain | Residue | Details |
C | THR66 | |
Chain | Residue | Details |
C | GLY76 | |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
Chain | Residue | Details |
C | GLY76 | |
Chain | Residue | Details |
C | LYS11 | |
C | LYS48 | |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
Chain | Residue | Details |
C | LYS27 | |
Chain | Residue | Details |
C | LYS29 | |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
Chain | Residue | Details |
C | LYS33 | |
Chain | Residue | Details |
C | LYS63 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 789 |
Chain | Residue | Details |
B | PHE234 | electrostatic stabiliser |
B | ARG239 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | PHE480 | proton acceptor, proton donor |
B | ASN497 | electrostatic stabiliser |