5KVI

Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0046983	molecular_function	protein dimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	binding site for residue FAD A 701

Chain	Residue
A	GLY138
A	PRO173
A	SER176
A	LYS177
A	LYS232
A	VAL233
A	ALA259
A	THR260
A	GLY261
A	ARG285
A	LYS286
A	GLY139
A	LEU311
A	GLY437
A	ASP438
A	GLU453
A	HIS454
A	HIS455
A	ALA458
A	PHE482
A	TRP483
A	HOH823
A	GLY140
A	HOH830
A	HOH840
A	HOH843
A	HOH848
A	HOH857
A	HOH866
A	HOH883
A	HOH964
A	HOH1007
A	HOH1009
A	THR141
A	ALA142
A	VAL162
A	GLU164
A	ASP165
A	ARG172

---

site_id	AC2
Number of Residues	10
Details	binding site for residue EPE A 702

Chain	Residue
A	ARG265
A	LYS342
A	ILE343
A	VAL398
A	GLY399
A	HIS454
A	PHE482
A	HOH942
A	HOH1050
A	HOH1091

---

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 703

Chain	Residue
A	VAL423
A	ASN424
A	ARG449
A	HOH804
A	HOH807
A	HOH1150
A	HOH1197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	349
Details	Region: {"description":"FAD-dependent oxidoreductase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22103349","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---