5KSW
DHODB-I74D mutant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0004589 | molecular_function | dihydroorotate dehydrogenase (NAD+) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0009055 | molecular_function | electron transfer activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
C | 0004589 | molecular_function | dihydroorotate dehydrogenase (NAD+) activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006222 | biological_process | UMP biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0009055 | molecular_function | electron transfer activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue FMN A 401 |
Chain | Residue |
A | ALA23 |
A | ASN132 |
A | LYS170 |
A | ILE196 |
A | ASN197 |
A | SER221 |
A | GLY222 |
A | MET247 |
A | GLY248 |
A | GLY249 |
A | GLY270 |
A | SER24 |
A | THR271 |
A | HOH533 |
A | HOH536 |
A | HOH554 |
A | GLY25 |
A | CYS26 |
A | LYS48 |
A | ALA49 |
A | ASN72 |
A | LEU76 |
A | ASN104 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue CL A 402 |
Chain | Residue |
A | THR51 |
A | LEU52 |
A | HIS53 |
A | HOH534 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue EDO A 403 |
Chain | Residue |
A | ARG203 |
A | LYS226 |
A | HOH526 |
A | HOH541 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue FAD B 301 |
Chain | Residue |
B | ARG53 |
B | PRO54 |
B | ILE55 |
B | SER56 |
B | LEU70 |
B | TYR71 |
B | ARG72 |
B | SER78 |
B | GLY79 |
B | THR80 |
B | ILE120 |
B | GLU221 |
B | SER222 |
B | ARG223 |
B | MET224 |
B | HOH405 |
B | HOH409 |
B | HOH430 |
B | HOH431 |
B | HOH440 |
B | HOH446 |
B | HOH447 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue FES B 302 |
Chain | Residue |
B | ALA225 |
B | CYS226 |
B | GLY227 |
B | GLY229 |
B | CYS231 |
B | TYR232 |
B | CYS234 |
B | CYS249 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CL B 303 |
Chain | Residue |
B | VAL63 |
site_id | AC7 |
Number of Residues | 20 |
Details | binding site for residue FAD D 301 |
Chain | Residue |
D | ARG53 |
D | PRO54 |
D | ILE55 |
D | SER56 |
D | LEU70 |
D | TYR71 |
D | ARG72 |
D | SER78 |
D | GLY79 |
D | THR80 |
D | ILE120 |
D | GLU221 |
D | SER222 |
D | ARG223 |
D | MET224 |
D | HOH404 |
D | HOH422 |
D | HOH431 |
D | HOH444 |
D | HOH453 |
site_id | AC8 |
Number of Residues | 22 |
Details | binding site for residue FMN C 401 |
Chain | Residue |
C | GLY249 |
C | GLY270 |
C | THR271 |
C | HOH502 |
C | HOH511 |
C | ALA23 |
C | SER24 |
C | GLY25 |
C | LYS48 |
C | ALA49 |
C | ASN72 |
C | LEU76 |
C | ASN104 |
C | ASN132 |
C | LYS170 |
C | ILE196 |
C | ASN197 |
C | THR198 |
C | SER221 |
C | GLY222 |
C | MET247 |
C | GLY248 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue EDO C 402 |
Chain | Residue |
C | ALA67 |
C | ARG203 |
C | LYS226 |
C | HOH521 |
C | HOH533 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01211 |
Chain | Residue | Details |
B | ARG53 | |
D | GLY79 | |
D | CYS226 | |
D | CYS231 | |
D | CYS234 | |
D | CYS249 | |
B | LEU70 | |
B | GLY79 | |
B | CYS226 | |
B | CYS231 | |
B | CYS234 | |
B | CYS249 | |
D | ARG53 | |
D | LEU70 |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER24 | |
A | GLY248 | |
A | GLY270 | |
C | SER24 | |
C | LYS48 | |
C | ASN72 | |
C | ASN104 | |
C | ASN132 | |
C | LYS170 | |
C | ILE196 | |
C | ASN197 | |
A | LYS48 | |
C | GLY222 | |
C | GLY248 | |
C | GLY270 | |
A | ASN72 | |
A | ASN104 | |
A | ASN132 | |
A | LYS170 | |
A | ILE196 | |
A | ASN197 | |
A | GLY222 |