5KS8

Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0046872	molecular_function	metal ion binding
B	0005524	molecular_function	ATP binding
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004736	molecular_function	pyruvate carboxylase activity
C	0005737	cellular_component	cytoplasm
C	0006094	biological_process	gluconeogenesis
C	0006814	biological_process	sodium ion transport
C	0008948	molecular_function	oxaloacetate decarboxylase activity
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004736	molecular_function	pyruvate carboxylase activity
D	0005737	cellular_component	cytoplasm
D	0006094	biological_process	gluconeogenesis
D	0006814	biological_process	sodium ion transport
D	0008948	molecular_function	oxaloacetate decarboxylase activity
D	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0004736	molecular_function	pyruvate carboxylase activity
E	0005737	cellular_component	cytoplasm
E	0006094	biological_process	gluconeogenesis
E	0006814	biological_process	sodium ion transport
E	0008948	molecular_function	oxaloacetate decarboxylase activity
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0004736	molecular_function	pyruvate carboxylase activity
F	0005737	cellular_component	cytoplasm
F	0006094	biological_process	gluconeogenesis
F	0006814	biological_process	sodium ion transport
F	0008948	molecular_function	oxaloacetate decarboxylase activity
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue BTI C 2000

Chain	Residue
C	LYS581
D	GLN342
D	PYR2001
D	GLN16
D	ASP52
D	TYR57
D	ARG83
D	TYR90
D	MET300
D	THR338
D	SER341

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site_id	AC2
Number of Residues	8
Details	binding site for residue PYR C 2001

Chain	Residue
C	ARG12
C	GLN16
C	GLY48
C	LEU81
C	ARG83
C	PHE116
C	LYS174
C	MET176

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site_id	AC3
Number of Residues	5
Details	binding site for residue MN C 2002

Chain	Residue
C	ASP13
C	LYS174
C	MET176
C	HIS203
C	HIS205

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site_id	AC4
Number of Residues	10
Details	binding site for residue PYR D 2001

Chain	Residue
C	BTI2000
D	ARG12
D	GLN16
D	GLY48
D	ALA49
D	LEU81
D	ARG83
D	PHE116
D	LYS174
D	THR338

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MN D 2002

Chain	Residue
D	ASP13
D	LYS174
D	HIS203
D	HIS205

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site_id	AC6
Number of Residues	4
Details	binding site for residue MN F 701

Chain	Residue
F	ASP13
F	LYS174
F	HIS203
F	HIS205

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Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GDaVlvIeAMKMeneIqA

Chain	Residue	Details
C	GLY571-ALA588

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site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FMEMNTRL

Chain	Residue	Details
A	PHE285-LEU292

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