5KP8
Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Acetyl Donor-ACP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004421 | molecular_function | hydroxymethylglutaryl-CoA synthase activity |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| A | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue PNS B 100 |
| Chain | Residue |
| A | ARG33 |
| B | SER39 |
| B | ARG42 |
| B | 6VG101 |
| B | HOH202 |
| B | HOH206 |
| B | HOH208 |
| A | LEU37 |
| A | PHE163 |
| A | PRO166 |
| A | SER167 |
| A | ALA213 |
| A | SER216 |
| A | PHE253 |
| A | ASN296 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue 6VG B 101 |
| Chain | Residue |
| A | ARG33 |
| A | GLU82 |
| A | ALA113 |
| A | SER114 |
| A | PHE163 |
| A | SER167 |
| A | HIS250 |
| A | PRO252 |
| A | PHE253 |
| A | ASN296 |
| A | GLY327 |
| A | SER328 |
| B | ASP38 |
| B | SER39 |
| B | ARG42 |
| B | PNS100 |
| B | HOH202 |
| B | HOH206 |
