5KO9

Crystal Structure of the SRAP Domain of Human HMCES Protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003697	molecular_function	single-stranded DNA binding
A	0006974	biological_process	DNA damage response
A	0106300	biological_process	protein-DNA covalent cross-linking repair

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30554877","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"37519246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37950866","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Required for sensing abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Required to stabilize abasic sites","evidences":[{"source":"UniProtKB","id":"P76318","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Thiazolidine linkage to a ring-opened DNA abasic site","evidences":[{"source":"PubMed","id":"31235913","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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