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5KO8

Crystal structure of haliscomenobacter hydrossis iodotyrosine deiodinase (IYD) bound to FMN and mono-iodotyrosine (I-Tyr)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0010181molecular_functionFMN binding
A0016491molecular_functionoxidoreductase activity
A0140616molecular_functioniodotyrosine deiodinase activity
B0000166molecular_functionnucleotide binding
B0010181molecular_functionFMN binding
B0016491molecular_functionoxidoreductase activity
B0140616molecular_functioniodotyrosine deiodinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue FMN A 301
ChainResidue
AARG34
ASER150
ALEU170
ATHR171
AHIS172
ATHR173
AARG212
AIYR302
AHOH418
AHOH424
AHOH427
AARG35
AHOH434
AHOH440
ATHR36
AARG38
APRO61
ASER62
AHIS65
APHE110
ATHR112

site_idAC2
Number of Residues13
Detailsbinding site for residue IYR A 302
ChainResidue
AARG38
AGLY63
AALA64
AGLU91
ATYR95
ALEU107
APHE110
ATHR112
AASP113
ALYS116
AHIS172
AFMN301
AHOH401

site_idAC3
Number of Residues19
Detailsbinding site for residue FMN B 301
ChainResidue
BARG34
BARG35
BTHR36
BARG38
BPRO61
BSER62
BHIS65
BPHE110
BGLU149
BLEU170
BTHR171
BTHR173
BARG212
BIYR302
BHOH416
BHOH417
BHOH422
BHOH425
BHOH437

site_idAC4
Number of Residues11
Detailsbinding site for residue IYR B 302
ChainResidue
BARG38
BGLY63
BALA64
BGLU91
BTYR95
BLEU107
BPHE110
BTHR112
BLYS116
BFMN301
BHOH436

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:28157283, ECO:0007744|PDB:5KO7, ECO:0007744|PDB:5KO8, ECO:0007744|PDB:5KRD
ChainResidueDetails
AARG34
ATHR171
AARG212
BARG34
BTHR171
BARG212

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:28157283, ECO:0007744|PDB:5KO8, ECO:0007744|PDB:5KRD
ChainResidueDetails
APRO61
BPRO61

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:28157283, ECO:0007744|PDB:5KO8
ChainResidueDetails
AGLU91
ATYR95
ALYS116
BGLU91
BTYR95
BLYS116

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PDB entries from 2024-11-06

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