Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5KNB

Crystal structure of the 2 ADP-bound V1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0045335	cellular_component	phagocytic vesicle
A	0046034	biological_process	ATP metabolic process
A	0046932	molecular_function	sodium-transporting ATP synthase activity, rotational mechanism
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	0046962	molecular_function	sodium-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005765	cellular_component	lysosomal membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0045335	cellular_component	phagocytic vesicle
B	0046034	biological_process	ATP metabolic process
B	0046932	molecular_function	sodium-transporting ATP synthase activity, rotational mechanism
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0046962	molecular_function	sodium-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005765	cellular_component	lysosomal membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0045335	cellular_component	phagocytic vesicle
C	0046034	biological_process	ATP metabolic process
C	0046932	molecular_function	sodium-transporting ATP synthase activity, rotational mechanism
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	0046962	molecular_function	sodium-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0007035	biological_process	vacuolar acidification
D	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0007035	biological_process	vacuolar acidification
E	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0006811	biological_process	monoatomic ion transport
F	0006814	biological_process	sodium ion transport
F	0007035	biological_process	vacuolar acidification
F	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005524	molecular_function	ATP binding
G	0006811	biological_process	monoatomic ion transport
G	0006814	biological_process	sodium ion transport
G	0007035	biological_process	vacuolar acidification
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005524	molecular_function	ATP binding
H	0006811	biological_process	monoatomic ion transport
H	0006814	biological_process	sodium ion transport
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MG B 601

Chain	Residue
B	THR239
B	GLU261
B	ARG262
B	GLU265
B	ADP602
B	HOH701
B	HOH702
B	HOH709

site_id	AC2
Number of Residues	12
Details	binding site for residue ADP B 602

Chain	Residue
B	ALA236
B	GLY237
B	LYS238
B	THR239
B	VAL240
B	PHE425
B	GLN503
B	ALA505
B	MG601
B	HOH701
E	ARG350
B	GLY235

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL B 603

Chain	Residue
B	ASP416
B	ASN429
B	TRP430

site_id	AC4
Number of Residues	6
Details	binding site for residue MG C 601

Chain	Residue
C	THR239
C	GLU265
C	ADP602
C	HOH701
C	HOH704
C	HOH705

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP C 602

Chain	Residue
C	PRO233
C	GLY235
C	ALA236
C	GLY237
C	LYS238
C	THR239
C	VAL240
C	PHE425
C	PRO426
C	ALA505
C	PHE506
C	MG601
C	HOH701
F	ARG350

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL E 501

Chain	Residue
B	PHE102
E	GLU114
E	GLU233
E	GLU238

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PPIDVLPSLS

Chain	Residue	Details
D	PRO340-SER349
A	PRO426-SER435

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLY232
B	GLY232
C	GLY232

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)