5KLP
Crystal structure of HopZ1a in complex with IP6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000822 | molecular_function | inositol hexakisphosphate binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016020 | cellular_component | membrane |
| A | 0016413 | molecular_function | O-acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042025 | cellular_component | host cell nucleus |
| A | 0044163 | cellular_component | host cytoskeleton |
| A | 0090729 | molecular_function | toxin activity |
| B | 0000822 | molecular_function | inositol hexakisphosphate binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0016020 | cellular_component | membrane |
| B | 0016413 | molecular_function | O-acetyltransferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042025 | cellular_component | host cell nucleus |
| B | 0044163 | cellular_component | host cytoskeleton |
| B | 0090729 | molecular_function | toxin activity |
| C | 0000822 | molecular_function | inositol hexakisphosphate binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0016020 | cellular_component | membrane |
| C | 0016413 | molecular_function | O-acetyltransferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0020002 | cellular_component | host cell plasma membrane |
| C | 0030430 | cellular_component | host cell cytoplasm |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0042025 | cellular_component | host cell nucleus |
| C | 0044163 | cellular_component | host cytoskeleton |
| C | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue IHP A 401 |
| Chain | Residue |
| A | ARG49 |
| A | SER314 |
| A | HIS317 |
| A | ARG326 |
| A | PHE355 |
| A | GLN358 |
| A | ARG362 |
| A | HOH528 |
| A | HOH540 |
| A | HOH558 |
| A | HOH564 |
| A | LYS53 |
| A | HOH565 |
| A | HOH585 |
| A | HOH601 |
| A | HOH608 |
| B | HOH531 |
| A | ARG106 |
| A | ASN222 |
| A | ILE225 |
| A | LYS226 |
| A | LYS229 |
| A | LYS289 |
| A | HIS290 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue CIT A 402 |
| Chain | Residue |
| A | HIS150 |
| A | GLY176 |
| A | ALA177 |
| A | ARG178 |
| A | TYR179 |
| A | GLN180 |
| A | GLN181 |
| A | ARG184 |
| A | HOH554 |
| A | HOH569 |
| A | HOH641 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CIT A 403 |
| Chain | Residue |
| A | ALA93 |
| A | HIS114 |
| A | PRO138 |
| A | LYS149 |
| A | HIS151 |
| A | HOH552 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue IHP B 401 |
| Chain | Residue |
| B | ARG49 |
| B | LYS53 |
| B | ARG106 |
| B | ASN222 |
| B | ILE225 |
| B | LYS226 |
| B | LYS229 |
| B | LYS289 |
| B | HIS290 |
| B | SER314 |
| B | HIS317 |
| B | ARG326 |
| B | PHE355 |
| B | GLN358 |
| B | ARG362 |
| B | HOH501 |
| B | HOH509 |
| B | HOH515 |
| B | HOH542 |
| B | HOH552 |
| B | HOH563 |
| B | HOH585 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue CIT B 402 |
| Chain | Residue |
| B | ALA93 |
| B | THR94 |
| B | HIS114 |
| B | PRO138 |
| B | LYS149 |
| B | HIS151 |
| B | HOH572 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue CIT B 403 |
| Chain | Residue |
| B | HIS150 |
| B | GLY176 |
| B | ALA177 |
| B | ARG178 |
| B | TYR179 |
| B | GLN180 |
| B | GLN181 |
| B | ARG184 |
| site_id | AC7 |
| Number of Residues | 25 |
| Details | binding site for residue IHP C 401 |
| Chain | Residue |
| C | HOH549 |
| C | HOH561 |
| C | HOH576 |
| C | HOH594 |
| C | ARG49 |
| C | LYS53 |
| C | ARG106 |
| C | ASN222 |
| C | ILE225 |
| C | LYS226 |
| C | LYS229 |
| C | LYS289 |
| C | HIS290 |
| C | SER314 |
| C | HIS317 |
| C | ARG326 |
| C | PHE355 |
| C | GLN358 |
| C | ARG362 |
| C | HOH502 |
| C | HOH504 |
| C | HOH514 |
| C | HOH517 |
| C | HOH528 |
| C | HOH542 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue CIT C 402 |
| Chain | Residue |
| C | HIS150 |
| C | GLY176 |
| C | ALA177 |
| C | ARG178 |
| C | TYR179 |
| C | GLN180 |
| C | GLN181 |
| C | ARG184 |
| C | HOH516 |
| C | HOH544 |
| C | HOH553 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue CIT C 403 |
| Chain | Residue |
| C | ALA93 |
| C | THR94 |
| C | HIS114 |
| C | ARG116 |
| C | PRO138 |
| C | LYS149 |
| C | HIS151 |
| C | HOH510 |
| C | HOH531 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:27525589 |
| Chain | Residue | Details |
| A | HIS150 | |
| A | GLU170 | |
| B | HIS150 | |
| B | GLU170 | |
| C | HIS150 | |
| C | GLU170 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:27525589, ECO:0000305|PubMed:22319451 |
| Chain | Residue | Details |
| A | CYS216 | |
| B | CYS216 | |
| C | CYS216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5KLP |
| Chain | Residue | Details |
| A | ARG49 | |
| B | ARG49 | |
| C | ARG49 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5KLP, ECO:0007744|PDB:5KLQ |
| Chain | Residue | Details |
| C | LYS53 | |
| C | ARG106 | |
| C | ASN222 | |
| C | LYS226 | |
| C | LYS289 | |
| C | SER314 | |
| C | ARG326 | |
| C | GLN358 | |
| C | ARG362 | |
| A | LYS226 | |
| A | LYS289 | |
| A | SER314 | |
| A | ARG326 | |
| A | GLN358 | |
| A | ARG362 | |
| B | LYS53 | |
| B | ARG106 | |
| B | ASN222 | |
| B | LYS226 | |
| B | LYS289 | |
| B | SER314 | |
| B | ARG326 | |
| B | GLN358 | |
| B | ARG362 | |
| A | LYS53 | |
| A | ARG106 | |
| A | ASN222 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5KLQ |
| Chain | Residue | Details |
| A | ALA292 | |
| A | ARG331 | |
| A | SER344 | |
| B | HIS150 | |
| B | ALA177 | |
| B | ALA211 | |
| B | ALA292 | |
| B | ARG331 | |
| B | SER344 | |
| C | HIS150 | |
| C | ALA177 | |
| C | ALA211 | |
| C | ALA292 | |
| C | ARG331 | |
| C | SER344 | |
| A | HIS150 | |
| A | ALA177 | |
| A | ALA211 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22319451, ECO:0000269|PubMed:26217317 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 | |
| C | LYS289 |
