5KB5

Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004001	molecular_function	adenosine kinase activity
A	0004136	molecular_function	deoxyadenosine kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006144	biological_process	purine nucleobase metabolic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0006170	biological_process	dAMP biosynthetic process
A	0006175	biological_process	dATP biosynthetic process
A	0010613	biological_process	positive regulation of cardiac muscle hypertrophy
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032261	biological_process	purine nucleotide salvage
A	0042102	biological_process	positive regulation of T cell proliferation
A	0044209	biological_process	AMP salvage
A	0044342	biological_process	type B pancreatic cell proliferation
A	0046085	biological_process	adenosine metabolic process
A	0046128	biological_process	purine ribonucleoside metabolic process
A	0046872	molecular_function	metal ion binding
A	0110052	biological_process	toxic metabolite repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ADN A 401

Chain	Residue
A	ASN30
A	PHE186
A	ASN312
A	GLY313
A	ASP316
A	CL404
A	HOH563
A	HOH567
A	HOH585
A	HOH607
A	LEU32
A	ASP34
A	GLY79
A	GLY80
A	SER81
A	ASN84
A	CYS139
A	ALA152

---

site_id	AC2
Number of Residues	27
Details	binding site for residue ADP A 402

Chain	Residue
A	ARG148
A	ASN239
A	THR281
A	GLN282
A	GLY283
A	ARG284
A	THR287
A	ASP302
A	GLN305
A	ILE308
A	ALA314
A	GLY315
A	HIS340
A	ALA343
A	MG405
A	MG406
A	HOH512
A	HOH518
A	HOH521
A	HOH522
A	HOH527
A	HOH535
A	HOH538
A	HOH554
A	HOH563
A	HOH568
A	HOH616

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 403

Chain	Residue
A	ASP310
A	ASN312
A	ILE346
A	ARG349
A	GLY351

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 404

Chain	Residue
A	GLY29
A	ASN30
A	THR82
A	ADN401

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 405

Chain	Residue
A	ADP402
A	HOH514
A	HOH517
A	HOH554
A	HOH555

---

site_id	AC6
Number of Residues	5
Details	binding site for residue MG A 406

Chain	Residue
A	ADP402
A	HOH522
A	HOH534
A	HOH538
A	HOH568

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PG4 A 407

Chain	Residue
A	HIS97
A	ALA120
A	HIS123
A	GLU356

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PG4 A 408

Chain	Residue
A	LEU168
A	ASP256
A	LYS262
A	ASP294
A	VAL295
A	HOH589

---

site_id	AC9
Number of Residues	4
Details	binding site for residue PO4 A 409

Chain	Residue
A	HIS127
A	ARG170
A	LYS258
A	HOH544

---

site_id	AD1
Number of Residues	6
Details	binding site for residue PO4 A 410

Chain	Residue
A	HIS77
A	LYS118
A	THR353
A	HOH509
A	HOH587
A	HOH600

---

Functional Information from PROSITE/UniProt

site_id	PS00584
Number of Residues	14
Details	PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL

Chain	Residue	Details
A	ASP310-LEU323

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P55263","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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