5KB5
Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004001 | molecular_function | adenosine kinase activity |
A | 0004136 | molecular_function | deoxyadenosine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006144 | biological_process | purine nucleobase metabolic process |
A | 0006166 | biological_process | purine ribonucleoside salvage |
A | 0006175 | biological_process | dATP biosynthetic process |
A | 0006753 | biological_process | nucleoside phosphate metabolic process |
A | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
A | 0016301 | molecular_function | kinase activity |
A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
A | 0032263 | biological_process | GMP salvage |
A | 0034654 | biological_process | nucleobase-containing compound biosynthetic process |
A | 0042102 | biological_process | positive regulation of T cell proliferation |
A | 0044209 | biological_process | AMP salvage |
A | 0044342 | biological_process | type B pancreatic cell proliferation |
A | 0046085 | biological_process | adenosine metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0106383 | biological_process | dAMP salvage |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue ADN A 401 |
Chain | Residue |
A | ASN30 |
A | PHE186 |
A | ASN312 |
A | GLY313 |
A | ASP316 |
A | CL404 |
A | HOH563 |
A | HOH567 |
A | HOH585 |
A | HOH607 |
A | LEU32 |
A | ASP34 |
A | GLY79 |
A | GLY80 |
A | SER81 |
A | ASN84 |
A | CYS139 |
A | ALA152 |
site_id | AC2 |
Number of Residues | 27 |
Details | binding site for residue ADP A 402 |
Chain | Residue |
A | ARG148 |
A | ASN239 |
A | THR281 |
A | GLN282 |
A | GLY283 |
A | ARG284 |
A | THR287 |
A | ASP302 |
A | GLN305 |
A | ILE308 |
A | ALA314 |
A | GLY315 |
A | HIS340 |
A | ALA343 |
A | MG405 |
A | MG406 |
A | HOH512 |
A | HOH518 |
A | HOH521 |
A | HOH522 |
A | HOH527 |
A | HOH535 |
A | HOH538 |
A | HOH554 |
A | HOH563 |
A | HOH568 |
A | HOH616 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue K A 403 |
Chain | Residue |
A | ASP310 |
A | ASN312 |
A | ILE346 |
A | ARG349 |
A | GLY351 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CL A 404 |
Chain | Residue |
A | GLY29 |
A | ASN30 |
A | THR82 |
A | ADN401 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue MG A 405 |
Chain | Residue |
A | ADP402 |
A | HOH514 |
A | HOH517 |
A | HOH554 |
A | HOH555 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MG A 406 |
Chain | Residue |
A | ADP402 |
A | HOH522 |
A | HOH534 |
A | HOH538 |
A | HOH568 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue PG4 A 407 |
Chain | Residue |
A | HIS97 |
A | ALA120 |
A | HIS123 |
A | GLU356 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue PG4 A 408 |
Chain | Residue |
A | LEU168 |
A | ASP256 |
A | LYS262 |
A | ASP294 |
A | VAL295 |
A | HOH589 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 409 |
Chain | Residue |
A | HIS127 |
A | ARG170 |
A | LYS258 |
A | HOH544 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 410 |
Chain | Residue |
A | HIS77 |
A | LYS118 |
A | THR353 |
A | HOH509 |
A | HOH587 |
A | HOH600 |
Functional Information from PROSITE/UniProt
site_id | PS00584 |
Number of Residues | 14 |
Details | PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTnGAGDafvGGFL |
Chain | Residue | Details |
A | ASP310-LEU323 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P55263 |
Chain | Residue | Details |
A | ASP316 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P55263 |
Chain | Residue | Details |
A | ASP34 | |
A | SER48 | |
A | ASN147 | |
A | GLN305 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P55263 |
Chain | Residue | Details |
A | TYR76 |