Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 601 |
| Chain | Residue |
| A | ASP370 |
| A | GLU409 |
| A | ASP417 |
| A | GLU419 |
| A | GLU422 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 602 |
| Chain | Residue |
| A | ASN415 |
| A | ASP417 |
| A | GLU422 |
| A | ASP423 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 603 |
| Chain | Residue |
| A | ASP289 |
| A | ASP291 |
| A | GLN293 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 604 |
| Chain | Residue |
| A | TYR425 |
| A | THR426 |
| A | ILE429 |
| A | ASP432 |
| A | HOH705 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 605 |
| Chain | Residue |
| A | HIS374 |
| A | GLU375 |
| A | HIS378 |
| A | TYR389 |
| A | GLU398 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 606 |
| Chain | Residue |
| A | HIS448 |
| A | SER450 |
| A | TYR483 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue IPA A 607 |
| Chain | Residue |
| A | ASN344 |
| A | GLU375 |
| A | LEU434 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL371-VAL380 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS374 | metal ligand |
| A | GLU375 | electrostatic stabiliser, metal ligand |
| A | HIS378 | metal ligand |
| A | TYR389 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU398 | metal ligand |
| A | ASP458 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS463 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
