5K56
Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006000 | biological_process | fructose metabolic process |
A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
A | 0006094 | biological_process | gluconeogenesis |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016791 | molecular_function | phosphatase activity |
A | 0030018 | cellular_component | Z disc |
A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
A | 0042132 | molecular_function | fructose 1,6-bisphosphate 1-phosphatase activity |
A | 0042578 | molecular_function | phosphoric ester hydrolase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070161 | cellular_component | anchoring junction |
Functional Information from PROSITE/UniProt
site_id | PS00124 |
Number of Residues | 13 |
Details | FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA |
Chain | Residue | Details |
A | GLY273-ALA285 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22120740 |
Chain | Residue | Details |
A | VAL17 | |
A | THR27 | |
A | LYS112 | |
A | ARG140 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ASP68 | |
A | GLU280 | |
A | GLU97 | |
A | ASP118 | |
A | LEU120 | |
A | ASP121 | |
A | ASN212 | |
A | TYR244 | |
A | TYR264 | |
A | LYS274 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Important for the conversion from active R-state to inactive T-state in the presence of AMP |
Chain | Residue | Details |
A | GLN32 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1 |
Chain | Residue | Details |
A | TYR215 | |
A | TYR218 |