5K51

Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0020015	cellular_component	glycosome
A	0031981	cellular_component	nuclear lumen
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
A	0097014	cellular_component	ciliary plasm
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0020015	cellular_component	glycosome
B	0031981	cellular_component	nuclear lumen
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0097014	cellular_component	ciliary plasm
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0020015	cellular_component	glycosome
C	0031981	cellular_component	nuclear lumen
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0097014	cellular_component	ciliary plasm
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0020015	cellular_component	glycosome
D	0031981	cellular_component	nuclear lumen
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0097014	cellular_component	ciliary plasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6QD A 301

Chain	Residue
A	ASP117
A	THR118
A	ALA119
A	THR121
A	LYS145
A	PHE166
A	VAL167
A	ASP173
A	HOH404

---

site_id	AC2
Number of Residues	10
Details	binding site for residue 6QD B 301

Chain	Residue
B	ILE115
B	ASP117
B	THR118
B	ALA119
B	THR121
B	LYS145
B	PHE166
B	VAL167
B	ASP173
B	HOH402

---

site_id	AC3
Number of Residues	12
Details	binding site for residue 6QD C 301

Chain	Residue
C	GLU113
C	ILE115
C	ASP117
C	THR118
C	ALA119
C	LEU120
C	THR121
C	LYS145
C	VAL165
C	PHE166
C	VAL167
C	HOH401

---

site_id	AC4
Number of Residues	10
Details	binding site for residue 6QD D 301

Chain	Residue
D	ILE115
D	ASP117
D	THR118
D	ALA119
D	THR121
D	LYS145
D	VAL165
D	PHE166
D	VAL167
D	ASP173

---

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLVLEDILDTAlT

Chain	Residue	Details
A	VAL109-THR121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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