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5K02

Structure of human SOD1 with T2D mutation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0000303biological_processresponse to superoxide
A0001541biological_processovarian follicle development
A0001819biological_processpositive regulation of cytokine production
A0001890biological_processplacenta development
A0001895biological_processretina homeostasis
A0001975biological_processresponse to amphetamine
A0002262biological_processmyeloid cell homeostasis
A0004784molecular_functionsuperoxide dismutase activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005764cellular_componentlysosome
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006801biological_processsuperoxide metabolic process
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007283biological_processspermatogenesis
A0007566biological_processembryo implantation
A0007605biological_processsensory perception of sound
A0007626biological_processlocomotory behavior
A0008089biological_processanterograde axonal transport
A0008090biological_processretrograde axonal transport
A0008217biological_processregulation of blood pressure
A0008270molecular_functionzinc ion binding
A0008340biological_processdetermination of adult lifespan
A0009408biological_processresponse to heat
A0009410biological_processresponse to xenobiotic stimulus
A0010467biological_processgene expression
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0019226biological_processtransmission of nerve impulse
A0019228biological_processneuronal action potential
A0019430biological_processremoval of superoxide radicals
A0019899molecular_functionenzyme binding
A0030141cellular_componentsecretory granule
A0030346molecular_functionprotein phosphatase 2B binding
A0031045cellular_componentdense core granule
A0031267molecular_functionsmall GTPase binding
A0031410cellular_componentcytoplasmic vesicle
A0031667biological_processresponse to nutrient levels
A0032287biological_processperipheral nervous system myelin maintenance
A0032839cellular_componentdendrite cytoplasm
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033081biological_processregulation of T cell differentiation in thymus
A0034465biological_processresponse to carbon monoxide
A0034599biological_processcellular response to oxidative stress
A0035234biological_processectopic germ cell programmed cell death
A0035865biological_processcellular response to potassium ion
A0040014biological_processregulation of multicellular organism growth
A0042542biological_processresponse to hydrogen peroxide
A0042554biological_processsuperoxide anion generation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043087biological_processregulation of GTPase activity
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0045471biological_processresponse to ethanol
A0046620biological_processregulation of organ growth
A0046688biological_processresponse to copper ion
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048538biological_processthymus development
A0048678biological_processresponse to axon injury
A0050665biological_processhydrogen peroxide biosynthetic process
A0050728biological_processnegative regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0051087molecular_functionprotein-folding chaperone binding
A0051093biological_processnegative regulation of developmental process
A0051881biological_processregulation of mitochondrial membrane potential
A0060047biological_processheart contraction
A0060052biological_processneurofilament cytoskeleton organization
A0060087biological_processrelaxation of vascular associated smooth muscle
A0060088biological_processauditory receptor cell stereocilium organization
A0070062cellular_componentextracellular exosome
A0071276biological_processcellular response to cadmium ion
A0071318biological_processcellular response to ATP
A0072593biological_processreactive oxygen species metabolic process
A0097332biological_processresponse to antipsychotic drug
A0099610biological_processaction potential initiation
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1904115cellular_componentaxon cytoplasm
A2000242biological_processnegative regulation of reproductive process
B0000302biological_processresponse to reactive oxygen species
B0000303biological_processresponse to superoxide
B0001541biological_processovarian follicle development
B0001819biological_processpositive regulation of cytokine production
B0001890biological_processplacenta development
B0001895biological_processretina homeostasis
B0001975biological_processresponse to amphetamine
B0002262biological_processmyeloid cell homeostasis
B0004784molecular_functionsuperoxide dismutase activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0005759cellular_componentmitochondrial matrix
B0005764cellular_componentlysosome
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006749biological_processglutathione metabolic process
B0006801biological_processsuperoxide metabolic process
B0006879biological_processintracellular iron ion homeostasis
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007283biological_processspermatogenesis
B0007566biological_processembryo implantation
B0007605biological_processsensory perception of sound
B0007626biological_processlocomotory behavior
B0008089biological_processanterograde axonal transport
B0008090biological_processretrograde axonal transport
B0008217biological_processregulation of blood pressure
B0008270molecular_functionzinc ion binding
B0008340biological_processdetermination of adult lifespan
B0009408biological_processresponse to heat
B0009410biological_processresponse to xenobiotic stimulus
B0010467biological_processgene expression
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0019226biological_processtransmission of nerve impulse
B0019228biological_processneuronal action potential
B0019430biological_processremoval of superoxide radicals
B0019899molecular_functionenzyme binding
B0030141cellular_componentsecretory granule
B0030346molecular_functionprotein phosphatase 2B binding
B0031045cellular_componentdense core granule
B0031267molecular_functionsmall GTPase binding
B0031410cellular_componentcytoplasmic vesicle
B0031667biological_processresponse to nutrient levels
B0032287biological_processperipheral nervous system myelin maintenance
B0032839cellular_componentdendrite cytoplasm
B0032930biological_processpositive regulation of superoxide anion generation
B0032991cellular_componentprotein-containing complex
B0033081biological_processregulation of T cell differentiation in thymus
B0034465biological_processresponse to carbon monoxide
B0034599biological_processcellular response to oxidative stress
B0035234biological_processectopic germ cell programmed cell death
B0035865biological_processcellular response to potassium ion
B0040014biological_processregulation of multicellular organism growth
B0042542biological_processresponse to hydrogen peroxide
B0042554biological_processsuperoxide anion generation
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043087biological_processregulation of GTPase activity
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0045471biological_processresponse to ethanol
B0046620biological_processregulation of organ growth
B0046688biological_processresponse to copper ion
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048538biological_processthymus development
B0048678biological_processresponse to axon injury
B0050665biological_processhydrogen peroxide biosynthetic process
B0050728biological_processnegative regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0051087molecular_functionprotein-folding chaperone binding
B0051093biological_processnegative regulation of developmental process
B0051881biological_processregulation of mitochondrial membrane potential
B0060047biological_processheart contraction
B0060052biological_processneurofilament cytoskeleton organization
B0060087biological_processrelaxation of vascular associated smooth muscle
B0060088biological_processauditory receptor cell stereocilium organization
B0070062cellular_componentextracellular exosome
B0071276biological_processcellular response to cadmium ion
B0071318biological_processcellular response to ATP
B0072593biological_processreactive oxygen species metabolic process
B0097332biological_processresponse to antipsychotic drug
B0099610biological_processaction potential initiation
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1904115cellular_componentaxon cytoplasm
B2000242biological_processnegative regulation of reproductive process
C0000302biological_processresponse to reactive oxygen species
C0000303biological_processresponse to superoxide
C0001541biological_processovarian follicle development
C0001819biological_processpositive regulation of cytokine production
C0001890biological_processplacenta development
C0001895biological_processretina homeostasis
C0001975biological_processresponse to amphetamine
C0002262biological_processmyeloid cell homeostasis
C0004784molecular_functionsuperoxide dismutase activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0005759cellular_componentmitochondrial matrix
C0005764cellular_componentlysosome
C0005777cellular_componentperoxisome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006749biological_processglutathione metabolic process
C0006801biological_processsuperoxide metabolic process
C0006879biological_processintracellular iron ion homeostasis
C0006915biological_processapoptotic process
C0006979biological_processresponse to oxidative stress
C0007283biological_processspermatogenesis
C0007566biological_processembryo implantation
C0007605biological_processsensory perception of sound
C0007626biological_processlocomotory behavior
C0008089biological_processanterograde axonal transport
C0008090biological_processretrograde axonal transport
C0008217biological_processregulation of blood pressure
C0008270molecular_functionzinc ion binding
C0008340biological_processdetermination of adult lifespan
C0009408biological_processresponse to heat
C0009410biological_processresponse to xenobiotic stimulus
C0010467biological_processgene expression
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0019226biological_processtransmission of nerve impulse
C0019228biological_processneuronal action potential
C0019430biological_processremoval of superoxide radicals
C0019899molecular_functionenzyme binding
C0030141cellular_componentsecretory granule
C0030346molecular_functionprotein phosphatase 2B binding
C0031045cellular_componentdense core granule
C0031267molecular_functionsmall GTPase binding
C0031410cellular_componentcytoplasmic vesicle
C0031667biological_processresponse to nutrient levels
C0032287biological_processperipheral nervous system myelin maintenance
C0032839cellular_componentdendrite cytoplasm
C0032930biological_processpositive regulation of superoxide anion generation
C0032991cellular_componentprotein-containing complex
C0033081biological_processregulation of T cell differentiation in thymus
C0034465biological_processresponse to carbon monoxide
C0034599biological_processcellular response to oxidative stress
C0035234biological_processectopic germ cell programmed cell death
C0035865biological_processcellular response to potassium ion
C0040014biological_processregulation of multicellular organism growth
C0042542biological_processresponse to hydrogen peroxide
C0042554biological_processsuperoxide anion generation
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043087biological_processregulation of GTPase activity
C0043410biological_processpositive regulation of MAPK cascade
C0043524biological_processnegative regulation of neuron apoptotic process
C0045471biological_processresponse to ethanol
C0046620biological_processregulation of organ growth
C0046688biological_processresponse to copper ion
C0046716biological_processmuscle cell cellular homeostasis
C0046872molecular_functionmetal ion binding
C0048538biological_processthymus development
C0048678biological_processresponse to axon injury
C0050665biological_processhydrogen peroxide biosynthetic process
C0050728biological_processnegative regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0051087molecular_functionprotein-folding chaperone binding
C0051093biological_processnegative regulation of developmental process
C0051881biological_processregulation of mitochondrial membrane potential
C0060047biological_processheart contraction
C0060052biological_processneurofilament cytoskeleton organization
C0060087biological_processrelaxation of vascular associated smooth muscle
C0060088biological_processauditory receptor cell stereocilium organization
C0070062cellular_componentextracellular exosome
C0071276biological_processcellular response to cadmium ion
C0071318biological_processcellular response to ATP
C0072593biological_processreactive oxygen species metabolic process
C0097332biological_processresponse to antipsychotic drug
C0099610biological_processaction potential initiation
C1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1904115cellular_componentaxon cytoplasm
C2000242biological_processnegative regulation of reproductive process
D0000302biological_processresponse to reactive oxygen species
D0000303biological_processresponse to superoxide
D0001541biological_processovarian follicle development
D0001819biological_processpositive regulation of cytokine production
D0001890biological_processplacenta development
D0001895biological_processretina homeostasis
D0001975biological_processresponse to amphetamine
D0002262biological_processmyeloid cell homeostasis
D0004784molecular_functionsuperoxide dismutase activity
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005758cellular_componentmitochondrial intermembrane space
D0005759cellular_componentmitochondrial matrix
D0005764cellular_componentlysosome
D0005777cellular_componentperoxisome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006749biological_processglutathione metabolic process
D0006801biological_processsuperoxide metabolic process
D0006879biological_processintracellular iron ion homeostasis
D0006915biological_processapoptotic process
D0006979biological_processresponse to oxidative stress
D0007283biological_processspermatogenesis
D0007566biological_processembryo implantation
D0007605biological_processsensory perception of sound
D0007626biological_processlocomotory behavior
D0008089biological_processanterograde axonal transport
D0008090biological_processretrograde axonal transport
D0008217biological_processregulation of blood pressure
D0008270molecular_functionzinc ion binding
D0008340biological_processdetermination of adult lifespan
D0009408biological_processresponse to heat
D0009410biological_processresponse to xenobiotic stimulus
D0010467biological_processgene expression
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0019226biological_processtransmission of nerve impulse
D0019228biological_processneuronal action potential
D0019430biological_processremoval of superoxide radicals
D0019899molecular_functionenzyme binding
D0030141cellular_componentsecretory granule
D0030346molecular_functionprotein phosphatase 2B binding
D0031045cellular_componentdense core granule
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0031667biological_processresponse to nutrient levels
D0032287biological_processperipheral nervous system myelin maintenance
D0032839cellular_componentdendrite cytoplasm
D0032930biological_processpositive regulation of superoxide anion generation
D0032991cellular_componentprotein-containing complex
D0033081biological_processregulation of T cell differentiation in thymus
D0034465biological_processresponse to carbon monoxide
D0034599biological_processcellular response to oxidative stress
D0035234biological_processectopic germ cell programmed cell death
D0035865biological_processcellular response to potassium ion
D0040014biological_processregulation of multicellular organism growth
D0042542biological_processresponse to hydrogen peroxide
D0042554biological_processsuperoxide anion generation
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043087biological_processregulation of GTPase activity
D0043410biological_processpositive regulation of MAPK cascade
D0043524biological_processnegative regulation of neuron apoptotic process
D0045471biological_processresponse to ethanol
D0046620biological_processregulation of organ growth
D0046688biological_processresponse to copper ion
D0046716biological_processmuscle cell cellular homeostasis
D0046872molecular_functionmetal ion binding
D0048538biological_processthymus development
D0048678biological_processresponse to axon injury
D0050665biological_processhydrogen peroxide biosynthetic process
D0050728biological_processnegative regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0051087molecular_functionprotein-folding chaperone binding
D0051093biological_processnegative regulation of developmental process
D0051881biological_processregulation of mitochondrial membrane potential
D0060047biological_processheart contraction
D0060052biological_processneurofilament cytoskeleton organization
D0060087biological_processrelaxation of vascular associated smooth muscle
D0060088biological_processauditory receptor cell stereocilium organization
D0070062cellular_componentextracellular exosome
D0071276biological_processcellular response to cadmium ion
D0071318biological_processcellular response to ATP
D0072593biological_processreactive oxygen species metabolic process
D0097332biological_processresponse to antipsychotic drug
D0099610biological_processaction potential initiation
D1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1904115cellular_componentaxon cytoplasm
D2000242biological_processnegative regulation of reproductive process
E0000302biological_processresponse to reactive oxygen species
E0000303biological_processresponse to superoxide
E0001541biological_processovarian follicle development
E0001819biological_processpositive regulation of cytokine production
E0001890biological_processplacenta development
E0001895biological_processretina homeostasis
E0001975biological_processresponse to amphetamine
E0002262biological_processmyeloid cell homeostasis
E0004784molecular_functionsuperoxide dismutase activity
E0005507molecular_functioncopper ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005758cellular_componentmitochondrial intermembrane space
E0005759cellular_componentmitochondrial matrix
E0005764cellular_componentlysosome
E0005777cellular_componentperoxisome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006749biological_processglutathione metabolic process
E0006801biological_processsuperoxide metabolic process
E0006879biological_processintracellular iron ion homeostasis
E0006915biological_processapoptotic process
E0006979biological_processresponse to oxidative stress
E0007283biological_processspermatogenesis
E0007566biological_processembryo implantation
E0007605biological_processsensory perception of sound
E0007626biological_processlocomotory behavior
E0008089biological_processanterograde axonal transport
E0008090biological_processretrograde axonal transport
E0008217biological_processregulation of blood pressure
E0008270molecular_functionzinc ion binding
E0008340biological_processdetermination of adult lifespan
E0009408biological_processresponse to heat
E0009410biological_processresponse to xenobiotic stimulus
E0010467biological_processgene expression
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0019226biological_processtransmission of nerve impulse
E0019228biological_processneuronal action potential
E0019430biological_processremoval of superoxide radicals
E0019899molecular_functionenzyme binding
E0030141cellular_componentsecretory granule
E0030346molecular_functionprotein phosphatase 2B binding
E0031045cellular_componentdense core granule
E0031267molecular_functionsmall GTPase binding
E0031410cellular_componentcytoplasmic vesicle
E0031667biological_processresponse to nutrient levels
E0032287biological_processperipheral nervous system myelin maintenance
E0032839cellular_componentdendrite cytoplasm
E0032930biological_processpositive regulation of superoxide anion generation
E0032991cellular_componentprotein-containing complex
E0033081biological_processregulation of T cell differentiation in thymus
E0034465biological_processresponse to carbon monoxide
E0034599biological_processcellular response to oxidative stress
E0035234biological_processectopic germ cell programmed cell death
E0035865biological_processcellular response to potassium ion
E0040014biological_processregulation of multicellular organism growth
E0042542biological_processresponse to hydrogen peroxide
E0042554biological_processsuperoxide anion generation
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043025cellular_componentneuronal cell body
E0043065biological_processpositive regulation of apoptotic process
E0043066biological_processnegative regulation of apoptotic process
E0043087biological_processregulation of GTPase activity
E0043410biological_processpositive regulation of MAPK cascade
E0043524biological_processnegative regulation of neuron apoptotic process
E0045471biological_processresponse to ethanol
E0046620biological_processregulation of organ growth
E0046688biological_processresponse to copper ion
E0046716biological_processmuscle cell cellular homeostasis
E0046872molecular_functionmetal ion binding
E0048538biological_processthymus development
E0048678biological_processresponse to axon injury
E0050665biological_processhydrogen peroxide biosynthetic process
E0050728biological_processnegative regulation of inflammatory response
E0050766biological_processpositive regulation of phagocytosis
E0051087molecular_functionprotein-folding chaperone binding
E0051093biological_processnegative regulation of developmental process
E0051881biological_processregulation of mitochondrial membrane potential
E0060047biological_processheart contraction
E0060052biological_processneurofilament cytoskeleton organization
E0060087biological_processrelaxation of vascular associated smooth muscle
E0060088biological_processauditory receptor cell stereocilium organization
E0070062cellular_componentextracellular exosome
E0071276biological_processcellular response to cadmium ion
E0071318biological_processcellular response to ATP
E0072593biological_processreactive oxygen species metabolic process
E0097332biological_processresponse to antipsychotic drug
E0099610biological_processaction potential initiation
E1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1904115cellular_componentaxon cytoplasm
E2000242biological_processnegative regulation of reproductive process
F0000302biological_processresponse to reactive oxygen species
F0000303biological_processresponse to superoxide
F0001541biological_processovarian follicle development
F0001819biological_processpositive regulation of cytokine production
F0001890biological_processplacenta development
F0001895biological_processretina homeostasis
F0001975biological_processresponse to amphetamine
F0002262biological_processmyeloid cell homeostasis
F0004784molecular_functionsuperoxide dismutase activity
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0005759cellular_componentmitochondrial matrix
F0005764cellular_componentlysosome
F0005777cellular_componentperoxisome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006749biological_processglutathione metabolic process
F0006801biological_processsuperoxide metabolic process
F0006879biological_processintracellular iron ion homeostasis
F0006915biological_processapoptotic process
F0006979biological_processresponse to oxidative stress
F0007283biological_processspermatogenesis
F0007566biological_processembryo implantation
F0007605biological_processsensory perception of sound
F0007626biological_processlocomotory behavior
F0008089biological_processanterograde axonal transport
F0008090biological_processretrograde axonal transport
F0008217biological_processregulation of blood pressure
F0008270molecular_functionzinc ion binding
F0008340biological_processdetermination of adult lifespan
F0009408biological_processresponse to heat
F0009410biological_processresponse to xenobiotic stimulus
F0010467biological_processgene expression
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0019226biological_processtransmission of nerve impulse
F0019228biological_processneuronal action potential
F0019430biological_processremoval of superoxide radicals
F0019899molecular_functionenzyme binding
F0030141cellular_componentsecretory granule
F0030346molecular_functionprotein phosphatase 2B binding
F0031045cellular_componentdense core granule
F0031267molecular_functionsmall GTPase binding
F0031410cellular_componentcytoplasmic vesicle
F0031667biological_processresponse to nutrient levels
F0032287biological_processperipheral nervous system myelin maintenance
F0032839cellular_componentdendrite cytoplasm
F0032930biological_processpositive regulation of superoxide anion generation
F0032991cellular_componentprotein-containing complex
F0033081biological_processregulation of T cell differentiation in thymus
F0034465biological_processresponse to carbon monoxide
F0034599biological_processcellular response to oxidative stress
F0035234biological_processectopic germ cell programmed cell death
F0035865biological_processcellular response to potassium ion
F0040014biological_processregulation of multicellular organism growth
F0042542biological_processresponse to hydrogen peroxide
F0042554biological_processsuperoxide anion generation
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043025cellular_componentneuronal cell body
F0043065biological_processpositive regulation of apoptotic process
F0043066biological_processnegative regulation of apoptotic process
F0043087biological_processregulation of GTPase activity
F0043410biological_processpositive regulation of MAPK cascade
F0043524biological_processnegative regulation of neuron apoptotic process
F0045471biological_processresponse to ethanol
F0046620biological_processregulation of organ growth
F0046688biological_processresponse to copper ion
F0046716biological_processmuscle cell cellular homeostasis
F0046872molecular_functionmetal ion binding
F0048538biological_processthymus development
F0048678biological_processresponse to axon injury
F0050665biological_processhydrogen peroxide biosynthetic process
F0050728biological_processnegative regulation of inflammatory response
F0050766biological_processpositive regulation of phagocytosis
F0051087molecular_functionprotein-folding chaperone binding
F0051093biological_processnegative regulation of developmental process
F0051881biological_processregulation of mitochondrial membrane potential
F0060047biological_processheart contraction
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X0035865biological_processcellular response to potassium ion
X0040014biological_processregulation of multicellular organism growth
X0042542biological_processresponse to hydrogen peroxide
X0042554biological_processsuperoxide anion generation
X0042802molecular_functionidentical protein binding
X0042803molecular_functionprotein homodimerization activity
X0043025cellular_componentneuronal cell body
X0043065biological_processpositive regulation of apoptotic process
X0043066biological_processnegative regulation of apoptotic process
X0043087biological_processregulation of GTPase activity
X0043410biological_processpositive regulation of MAPK cascade
X0043524biological_processnegative regulation of neuron apoptotic process
X0045471biological_processresponse to ethanol
X0046620biological_processregulation of organ growth
X0046688biological_processresponse to copper ion
X0046716biological_processmuscle cell cellular homeostasis
X0046872molecular_functionmetal ion binding
X0048538biological_processthymus development
X0048678biological_processresponse to axon injury
X0050665biological_processhydrogen peroxide biosynthetic process
X0050728biological_processnegative regulation of inflammatory response
X0050766biological_processpositive regulation of phagocytosis
X0051087molecular_functionprotein-folding chaperone binding
X0051093biological_processnegative regulation of developmental process
X0051881biological_processregulation of mitochondrial membrane potential
X0060047biological_processheart contraction
X0060052biological_processneurofilament cytoskeleton organization
X0060087biological_processrelaxation of vascular associated smooth muscle
X0060088biological_processauditory receptor cell stereocilium organization
X0070062cellular_componentextracellular exosome
X0071276biological_processcellular response to cadmium ion
X0071318biological_processcellular response to ATP
X0072593biological_processreactive oxygen species metabolic process
X0097332biological_processresponse to antipsychotic drug
X0099610biological_processaction potential initiation
X1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
X1904115cellular_componentaxon cytoplasm
X2000242biological_processnegative regulation of reproductive process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CU A 201
ChainResidue
AHIS46
AHIS48
AHIS63
AHIS120
AHOH331

site_idAC2
Number of Residues5
Detailsbinding site for residue ZN A 202
ChainResidue
ALYS136
AHIS63
AHIS71
AHIS80
AASP83

site_idAC3
Number of Residues5
Detailsbinding site for residue CU B 201
ChainResidue
BHIS46
BHIS48
BHIS63
BHIS120
BHOH325

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN B 202
ChainResidue
BHIS63
BHIS71
BHIS80
BASP83
BLYS136

site_idAC5
Number of Residues4
Detailsbinding site for residue CU C 201
ChainResidue
CHIS46
CHIS48
CHIS63
CHIS120

site_idAC6
Number of Residues5
Detailsbinding site for residue ZN C 202
ChainResidue
CHIS63
CHIS71
CHIS80
CASP83
CLYS136

site_idAC7
Number of Residues5
Detailsbinding site for residue CU D 201
ChainResidue
DHIS46
DHIS48
DHIS63
DHIS120
DHOH333

site_idAC8
Number of Residues5
Detailsbinding site for residue ZN D 202
ChainResidue
DHIS63
DHIS71
DHIS80
DASP83
DLYS136

site_idAC9
Number of Residues3
Detailsbinding site for residue CU E 201
ChainResidue
EHIS46
EHIS48
EHIS120

site_idAD1
Number of Residues4
Detailsbinding site for residue ZN E 202
ChainResidue
EHIS63
EHIS71
EHIS80
EASP83

site_idAD2
Number of Residues5
Detailsbinding site for residue CU F 201
ChainResidue
FHIS46
FHIS48
FHIS63
FHIS120
FHOH315

site_idAD3
Number of Residues4
Detailsbinding site for residue ZN F 202
ChainResidue
FHIS63
FHIS71
FHIS80
FASP83

site_idAD4
Number of Residues4
Detailsbinding site for residue CU G 201
ChainResidue
GHIS46
GHIS48
GHIS63
GHIS120

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN G 202
ChainResidue
GHIS63
GHIS71
GHIS80
GASP83

site_idAD6
Number of Residues5
Detailsbinding site for residue CU H 201
ChainResidue
HHIS46
HHIS48
HHIS63
HHIS120
HHOH305

site_idAD7
Number of Residues4
Detailsbinding site for residue ZN H 202
ChainResidue
HHIS63
HHIS71
HHIS80
HASP83

site_idAD8
Number of Residues4
Detailsbinding site for residue CU I 201
ChainResidue
IHIS46
IHIS48
IHIS63
IHIS120

site_idAD9
Number of Residues4
Detailsbinding site for residue ZN I 202
ChainResidue
IHIS63
IHIS71
IHIS80
IASP83

site_idAE1
Number of Residues3
Detailsbinding site for residue CU J 201
ChainResidue
JHIS46
JHIS48
JHIS120

site_idAE2
Number of Residues4
Detailsbinding site for residue ZN J 202
ChainResidue
JHIS63
JHIS71
JHIS80
JASP83

site_idAE3
Number of Residues4
Detailsbinding site for residue CU K 201
ChainResidue
KHIS46
KHIS48
KHIS63
KHIS120

site_idAE4
Number of Residues4
Detailsbinding site for residue ZN K 202
ChainResidue
KHIS63
KHIS71
KHIS80
KASP83

site_idAE5
Number of Residues6
Detailsbinding site for residue CU L 201
ChainResidue
LHOH301
LHOH303
LHIS46
LHIS48
LHIS63
LHIS120

site_idAE6
Number of Residues5
Detailsbinding site for residue ZN L 202
ChainResidue
LHIS63
LHIS71
LHIS80
LASP83
LLYS136

site_idAE7
Number of Residues4
Detailsbinding site for residue CU M 201
ChainResidue
MHIS46
MHIS48
MHIS63
MHIS120

site_idAE8
Number of Residues4
Detailsbinding site for residue ZN M 202
ChainResidue
MHIS63
MHIS71
MHIS80
MASP83

site_idAE9
Number of Residues4
Detailsbinding site for residue CU N 201
ChainResidue
NHIS46
NHIS48
NHIS63
NHIS120

site_idAF1
Number of Residues4
Detailsbinding site for residue ZN N 202
ChainResidue
NHIS63
NHIS71
NHIS80
NASP83

site_idAF2
Number of Residues4
Detailsbinding site for residue CU O 201
ChainResidue
OHIS46
OHIS48
OHIS63
OHIS120

site_idAF3
Number of Residues4
Detailsbinding site for residue ZN O 202
ChainResidue
OHIS63
OHIS71
OHIS80
OASP83

site_idAF4
Number of Residues4
Detailsbinding site for residue CU P 201
ChainResidue
PHIS46
PHIS48
PHIS63
PHIS120

site_idAF5
Number of Residues4
Detailsbinding site for residue ZN P 202
ChainResidue
PHIS63
PHIS71
PHIS80
PASP83

site_idAF6
Number of Residues4
Detailsbinding site for residue CU Q 201
ChainResidue
QHIS46
QHIS48
QHIS63
QHIS120

site_idAF7
Number of Residues5
Detailsbinding site for residue ZN Q 202
ChainResidue
QHIS63
QHIS71
QHIS80
QASP83
QLYS136

site_idAF8
Number of Residues4
Detailsbinding site for residue CU R 201
ChainResidue
RHIS46
RHIS48
RHIS63
RHIS120

site_idAF9
Number of Residues4
Detailsbinding site for residue ZN R 202
ChainResidue
RHIS63
RHIS71
RHIS80
RASP83

site_idAG1
Number of Residues5
Detailsbinding site for residue CU S 201
ChainResidue
SHIS46
SHIS48
SHIS63
SHIS120
SHOH314

site_idAG2
Number of Residues5
Detailsbinding site for residue ZN S 202
ChainResidue
SHIS63
SHIS71
SHIS80
SASP83
SLYS136

site_idAG3
Number of Residues4
Detailsbinding site for residue CU T 201
ChainResidue
THIS46
THIS48
THIS63
THIS120

site_idAG4
Number of Residues5
Detailsbinding site for residue ZN T 202
ChainResidue
THIS63
THIS71
THIS80
TASP83
TLYS136

site_idAG5
Number of Residues4
Detailsbinding site for residue CU U 201
ChainResidue
UHIS46
UHIS48
UHIS63
UHIS120

site_idAG6
Number of Residues5
Detailsbinding site for residue ZN U 202
ChainResidue
UHIS63
UHIS71
UHIS80
UASP83
ULYS136

site_idAG7
Number of Residues4
Detailsbinding site for residue CU V 201
ChainResidue
VHIS46
VHIS48
VHIS63
VHIS120

site_idAG8
Number of Residues4
Detailsbinding site for residue ZN V 202
ChainResidue
VHIS63
VHIS71
VHIS80
VASP83

site_idAG9
Number of Residues4
Detailsbinding site for residue CU W 201
ChainResidue
WHIS46
WHIS48
WHIS63
WHIS120

site_idAH1
Number of Residues4
Detailsbinding site for residue ZN W 202
ChainResidue
WHIS63
WHIS71
WHIS80
WASP83

site_idAH2
Number of Residues4
Detailsbinding site for residue CU X 201
ChainResidue
XHIS46
XHIS48
XHIS63
XHIS120

site_idAH3
Number of Residues4
Detailsbinding site for residue ZN X 202
ChainResidue
XHIS63
XHIS71
XHIS80
XASP83

Functional Information from PROSITE/UniProt
site_idPS00087
Number of Residues11
DetailsSOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT
ChainResidueDetails
AGLY44-THR54

site_idPS00332
Number of Residues12
DetailsSOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI
ChainResidueDetails
AGLY138-ILE149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues96
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues24
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues72
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues24
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues24
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues48
DetailsCross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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