5JYE

Structures of Streptococcus agalactiae GBS GAPDH in different enzymatic states

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0005737	cellular_component	cytoplasm
A	0006006	biological_process	glucose metabolic process
A	0006096	biological_process	glycolytic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B	0005737	cellular_component	cytoplasm
B	0006006	biological_process	glucose metabolic process
B	0006096	biological_process	glycolytic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0000166	molecular_function	nucleotide binding
C	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C	0005737	cellular_component	cytoplasm
C	0006006	biological_process	glucose metabolic process
C	0006096	biological_process	glycolytic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0005737	cellular_component	cytoplasm
D	0006006	biological_process	glucose metabolic process
D	0006096	biological_process	glycolytic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue NAD A 401

Chain	Residue
A	GLY9
A	THR97
A	GLY98
A	PHE99
A	PHE100
A	THR121
A	ALA122
A	ASN316
A	TYR320
A	HOH501
A	HOH506
A	PHE10
A	HOH513
A	HOH531
A	HOH532
A	HOH541
C	PRO191
A	GLY11
A	ARG12
A	ILE13
A	ASP34
A	LEU35
A	ARG78
A	ALA96

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site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 402

Chain	Residue
A	ILE21
A	VAL24
A	VAL27
A	HOH533

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site_id	AC3
Number of Residues	24
Details	binding site for residue NAD C 401

Chain	Residue
A	PRO191
A	HOH521
C	ASN8
C	GLY9
C	GLY11
C	ARG12
C	ILE13
C	ASN33
C	ASP34
C	LEU35
C	ARG78
C	ALA96
C	THR97
C	GLY98
C	PHE99
C	PHE100
C	THR121
C	ALA122
C	CYS152
C	ASN316
C	TYR320
C	HOH524
C	HOH530
C	HOH532

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site_id	AC4
Number of Residues	3
Details	binding site for residue MG C 402

Chain	Residue
C	ILE21
C	VAL24
C	VAL27

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Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA150-LEU157

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