5JUY

Active human apoptosome with procaspase-9

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001666	biological_process	response to hypoxia
A	0001822	biological_process	kidney development
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006915	biological_process	apoptotic process
A	0007399	biological_process	nervous system development
A	0007584	biological_process	response to nutrient
A	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0030154	biological_process	cell differentiation
A	0031072	molecular_function	heat shock protein binding
A	0032991	cellular_component	protein-containing complex
A	0034774	cellular_component	secretory granule lumen
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043293	cellular_component	apoptosome
A	0043531	molecular_function	ADP binding
A	0048731	biological_process	system development
A	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A	0070062	cellular_component	extracellular exosome
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	0072432	biological_process	response to G1 DNA damage checkpoint signaling
A	0097190	biological_process	apoptotic signaling pathway
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0140608	molecular_function	cysteine-type endopeptidase activator activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0001666	biological_process	response to hypoxia
B	0001822	biological_process	kidney development
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006915	biological_process	apoptotic process
B	0007399	biological_process	nervous system development
B	0007584	biological_process	response to nutrient
B	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0030154	biological_process	cell differentiation
B	0031072	molecular_function	heat shock protein binding
B	0032991	cellular_component	protein-containing complex
B	0034774	cellular_component	secretory granule lumen
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043293	cellular_component	apoptosome
B	0043531	molecular_function	ADP binding
B	0048731	biological_process	system development
B	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
B	0070062	cellular_component	extracellular exosome
B	0071560	biological_process	cellular response to transforming growth factor beta stimulus
B	0072432	biological_process	response to G1 DNA damage checkpoint signaling
B	0097190	biological_process	apoptotic signaling pathway
B	0097193	biological_process	intrinsic apoptotic signaling pathway
B	0140608	molecular_function	cysteine-type endopeptidase activator activity
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0001666	biological_process	response to hypoxia
C	0001822	biological_process	kidney development
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006915	biological_process	apoptotic process
C	0007399	biological_process	nervous system development
C	0007584	biological_process	response to nutrient
C	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
C	0010659	biological_process	cardiac muscle cell apoptotic process
C	0030154	biological_process	cell differentiation
C	0031072	molecular_function	heat shock protein binding
C	0032991	cellular_component	protein-containing complex
C	0034774	cellular_component	secretory granule lumen
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043293	cellular_component	apoptosome
C	0043531	molecular_function	ADP binding
C	0048731	biological_process	system development
C	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
C	0070062	cellular_component	extracellular exosome
C	0071560	biological_process	cellular response to transforming growth factor beta stimulus
C	0072432	biological_process	response to G1 DNA damage checkpoint signaling
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0140608	molecular_function	cysteine-type endopeptidase activator activity
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0001666	biological_process	response to hypoxia
D	0001822	biological_process	kidney development
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006915	biological_process	apoptotic process
D	0007399	biological_process	nervous system development
D	0007584	biological_process	response to nutrient
D	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
D	0010659	biological_process	cardiac muscle cell apoptotic process
D	0030154	biological_process	cell differentiation
D	0031072	molecular_function	heat shock protein binding
D	0032991	cellular_component	protein-containing complex
D	0034774	cellular_component	secretory granule lumen
D	0042802	molecular_function	identical protein binding
D	0042981	biological_process	regulation of apoptotic process
D	0043065	biological_process	positive regulation of apoptotic process
D	0043293	cellular_component	apoptosome
D	0043531	molecular_function	ADP binding
D	0048731	biological_process	system development
D	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
D	0070062	cellular_component	extracellular exosome
D	0071560	biological_process	cellular response to transforming growth factor beta stimulus
D	0072432	biological_process	response to G1 DNA damage checkpoint signaling
D	0097190	biological_process	apoptotic signaling pathway
D	0097193	biological_process	intrinsic apoptotic signaling pathway
D	0140608	molecular_function	cysteine-type endopeptidase activator activity
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0001666	biological_process	response to hypoxia
E	0001822	biological_process	kidney development
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006915	biological_process	apoptotic process
E	0007399	biological_process	nervous system development
E	0007584	biological_process	response to nutrient
E	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
E	0010659	biological_process	cardiac muscle cell apoptotic process
E	0030154	biological_process	cell differentiation
E	0031072	molecular_function	heat shock protein binding
E	0032991	cellular_component	protein-containing complex
E	0034774	cellular_component	secretory granule lumen
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043065	biological_process	positive regulation of apoptotic process
E	0043293	cellular_component	apoptosome
E	0043531	molecular_function	ADP binding
E	0048731	biological_process	system development
E	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
E	0070062	cellular_component	extracellular exosome
E	0071560	biological_process	cellular response to transforming growth factor beta stimulus
E	0072432	biological_process	response to G1 DNA damage checkpoint signaling
E	0097190	biological_process	apoptotic signaling pathway
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0140608	molecular_function	cysteine-type endopeptidase activator activity
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0001666	biological_process	response to hypoxia
F	0001822	biological_process	kidney development
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006915	biological_process	apoptotic process
F	0007399	biological_process	nervous system development
F	0007584	biological_process	response to nutrient
F	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
F	0010659	biological_process	cardiac muscle cell apoptotic process
F	0030154	biological_process	cell differentiation
F	0031072	molecular_function	heat shock protein binding
F	0032991	cellular_component	protein-containing complex
F	0034774	cellular_component	secretory granule lumen
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043065	biological_process	positive regulation of apoptotic process
F	0043293	cellular_component	apoptosome
F	0043531	molecular_function	ADP binding
F	0048731	biological_process	system development
F	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
F	0070062	cellular_component	extracellular exosome
F	0071560	biological_process	cellular response to transforming growth factor beta stimulus
F	0072432	biological_process	response to G1 DNA damage checkpoint signaling
F	0097190	biological_process	apoptotic signaling pathway
F	0097193	biological_process	intrinsic apoptotic signaling pathway
F	0140608	molecular_function	cysteine-type endopeptidase activator activity
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0001666	biological_process	response to hypoxia
G	0001822	biological_process	kidney development
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006915	biological_process	apoptotic process
G	0007399	biological_process	nervous system development
G	0007584	biological_process	response to nutrient
G	0008656	molecular_function	cysteine-type endopeptidase activator activity involved in apoptotic process
G	0010659	biological_process	cardiac muscle cell apoptotic process
G	0030154	biological_process	cell differentiation
G	0031072	molecular_function	heat shock protein binding
G	0032991	cellular_component	protein-containing complex
G	0034774	cellular_component	secretory granule lumen
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043065	biological_process	positive regulation of apoptotic process
G	0043293	cellular_component	apoptosome
G	0043531	molecular_function	ADP binding
G	0048731	biological_process	system development
G	0070059	biological_process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
G	0070062	cellular_component	extracellular exosome
G	0071560	biological_process	cellular response to transforming growth factor beta stimulus
G	0072432	biological_process	response to G1 DNA damage checkpoint signaling
G	0097190	biological_process	apoptotic signaling pathway
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0140608	molecular_function	cysteine-type endopeptidase activator activity
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0005758	cellular_component	mitochondrial intermembrane space
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0006915	biological_process	apoptotic process
H	0009055	molecular_function	electron transfer activity
H	0020037	molecular_function	heme binding
H	0022904	biological_process	respiratory electron transport chain
H	0046872	molecular_function	metal ion binding
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
I	0006915	biological_process	apoptotic process
I	0009055	molecular_function	electron transfer activity
I	0020037	molecular_function	heme binding
I	0022904	biological_process	respiratory electron transport chain
I	0046872	molecular_function	metal ion binding
J	0005758	cellular_component	mitochondrial intermembrane space
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0006915	biological_process	apoptotic process
J	0009055	molecular_function	electron transfer activity
J	0020037	molecular_function	heme binding
J	0022904	biological_process	respiratory electron transport chain
J	0046872	molecular_function	metal ion binding
K	0005758	cellular_component	mitochondrial intermembrane space
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0006915	biological_process	apoptotic process
K	0009055	molecular_function	electron transfer activity
K	0020037	molecular_function	heme binding
K	0022904	biological_process	respiratory electron transport chain
K	0046872	molecular_function	metal ion binding
L	0005758	cellular_component	mitochondrial intermembrane space
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0006915	biological_process	apoptotic process
L	0009055	molecular_function	electron transfer activity
L	0020037	molecular_function	heme binding
L	0022904	biological_process	respiratory electron transport chain
L	0046872	molecular_function	metal ion binding
M	0005758	cellular_component	mitochondrial intermembrane space
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0006915	biological_process	apoptotic process
M	0009055	molecular_function	electron transfer activity
M	0020037	molecular_function	heme binding
M	0022904	biological_process	respiratory electron transport chain
M	0046872	molecular_function	metal ion binding
N	0005758	cellular_component	mitochondrial intermembrane space
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0006915	biological_process	apoptotic process
N	0009055	molecular_function	electron transfer activity
N	0020037	molecular_function	heme binding
N	0022904	biological_process	respiratory electron transport chain
N	0046872	molecular_function	metal ion binding
O	0002020	molecular_function	protease binding
O	0042981	biological_process	regulation of apoptotic process
O	0070513	molecular_function	death domain binding
P	0002020	molecular_function	protease binding
P	0042981	biological_process	regulation of apoptotic process
P	0070513	molecular_function	death domain binding
Q	0002020	molecular_function	protease binding
Q	0042981	biological_process	regulation of apoptotic process
Q	0070513	molecular_function	death domain binding
R	0002020	molecular_function	protease binding
R	0042981	biological_process	regulation of apoptotic process
R	0070513	molecular_function	death domain binding

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATCsvDkKVKIWNS

Chain	Residue	Details
A	ILE672-SER686
A	LEU716-LEU730
A	LEU758-ALA772
A	LEU1142-VAL1156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	273
Details	Repeat: {"description":"WD 1-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	273
Details	Repeat: {"description":"WD 1-2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	287
Details	Repeat: {"description":"WD 1-3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	273
Details	Repeat: {"description":"WD 1-4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	280
Details	Repeat: {"description":"WD 1-5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	273
Details	Repeat: {"description":"WD 1-6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	210
Details	Repeat: {"description":"WD 1-7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	252
Details	Repeat: {"description":"WD 2-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	273
Details	Repeat: {"description":"WD 2-2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	273
Details	Repeat: {"description":"WD 2-3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	266
Details	Repeat: {"description":"WD 2-4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	273
Details	Repeat: {"description":"WD 2-5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	273
Details	Repeat: {"description":"WD 2-6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	259
Details	Repeat: {"description":"WD 2-7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	245
Details	Repeat: {"description":"WD 2-8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	77
Details	Region: {"description":"Interpropeller linker","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	49
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	720
Details	Domain: {"description":"CARD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00046","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	14
Details	Binding site: {"description":"covalent"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	14
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	7
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"5933874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"16866357","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18471988","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	7
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Propeptide: {"featureId":"PRO_0000004640","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 816

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 816

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 816

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues
Details	M-CSA 816

Chain

Residue

Details

---