5JSG
Crystal structure of Spindlin1 bound to compound EML405
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 6P9 A 301 |
| Chain | Residue |
| A | TRP62 |
| A | HOH435 |
| A | TRP72 |
| A | TYR91 |
| A | TYR98 |
| A | LEU100 |
| A | PHE141 |
| A | TRP151 |
| A | TYR170 |
| A | ASP173 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | HOH421 |
| A | HOH424 |
| A | HOH438 |
| B | HOH414 |
| B | HOH418 |
| B | HOH440 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | ARG152 |
| A | LYS172 |
| A | HOH428 |
| B | HOH414 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 6P9 B 301 |
| Chain | Residue |
| B | HIS60 |
| B | TRP62 |
| B | TRP72 |
| B | TYR91 |
| B | PHE94 |
| B | TYR98 |
| B | LEU100 |
| B | PHE141 |
| B | TRP151 |
| B | ASP173 |
| B | TYR177 |
| B | TYR179 |
| B | HOH442 |
| B | HOH447 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 302 |
| Chain | Residue |
| A | ARG152 |
| B | ARG152 |
| B | LYS172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 126 |
| Details | Region: {"description":"Tudor-like domain 1","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 122 |
| Details | Region: {"description":"Tudor-like domain 2","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Histone H3K4me3 and H3R8me2a binding","evidences":[{"source":"PubMed","id":"23077255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24589551","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"22258766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
