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5JPT

CRYSTAL STRUCTURE OF THE PRP43P DEAH-BOX RNA HELICASE IN COMPLEX WITH CDP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000390biological_processspliceosomal complex disassembly
A0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0000466biological_processmaturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003729molecular_functionmRNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005681cellular_componentspliceosomal complex
A0005730cellular_componentnucleolus
A0005739cellular_componentmitochondrion
A0006364biological_processrRNA processing
A0006396biological_processRNA processing
A0006397biological_processmRNA processing
A0008186molecular_functionATP-dependent activity, acting on RNA
A0008380biological_processRNA splicing
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0022613biological_processribonucleoprotein complex biogenesis
A0030490biological_processmaturation of SSU-rRNA
A0030686cellular_component90S preribosome
A0032040cellular_componentsmall-subunit processome
A0042273biological_processribosomal large subunit biogenesis
A0071014cellular_componentpost-mRNA release spliceosomal complex
A1990904cellular_componentribonucleoprotein complex
B0000390biological_processspliceosomal complex disassembly
B0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0000466biological_processmaturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003729molecular_functionmRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005681cellular_componentspliceosomal complex
B0005730cellular_componentnucleolus
B0005739cellular_componentmitochondrion
B0006364biological_processrRNA processing
B0006396biological_processRNA processing
B0006397biological_processmRNA processing
B0008186molecular_functionATP-dependent activity, acting on RNA
B0008380biological_processRNA splicing
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0022613biological_processribonucleoprotein complex biogenesis
B0030490biological_processmaturation of SSU-rRNA
B0030686cellular_component90S preribosome
B0032040cellular_componentsmall-subunit processome
B0042273biological_processribosomal large subunit biogenesis
B0071014cellular_componentpost-mRNA release spliceosomal complex
B1990904cellular_componentribonucleoprotein complex
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue CDP A 801
ChainResidue
ATHR118
AARG159
APHE357
ATHR384
AASP386
AARG430
AMG802
AHOH901
AHOH903
AGLY119
ASER120
AGLY121
ALYS122
ATHR123
ATHR124
ASER155
AVAL156

site_idAC2
Number of Residues8
Detailsbinding site for residue MG A 802
ChainResidue
ATHR123
AGLU216
ASER382
ACDP801
AHOH901
AHOH902
AHOH903
AHOH904

site_idAC3
Number of Residues4
Detailsbinding site for residue GOL A 803
ChainResidue
ALEU549
AVAL551
AGLU698
ATHR709

site_idAC4
Number of Residues3
Detailsbinding site for residue ACT A 804
ChainResidue
ATYR345
AGLY346
ATHR376

site_idAC5
Number of Residues2
Detailsbinding site for residue NI A 805
ChainResidue
AHIS479
AHIS606

site_idAC6
Number of Residues20
Detailsbinding site for residue CDP B 801
ChainResidue
BGLU117
BTHR118
BGLY119
BSER120
BGLY121
BLYS122
BTHR123
BTHR124
BSER155
BVAL156
BARG159
BPHE357
BTHR384
BASP386
BARG430
BMG802
BHOH901
BHOH902
BHOH903
BHOH906

site_idAC7
Number of Residues8
Detailsbinding site for residue MG B 802
ChainResidue
BTHR123
BGLU216
BSER382
BCDP801
BHOH902
BHOH903
BHOH905
BHOH906

Functional Information from PROSITE/UniProt
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIILDEAHE
ChainResidueDetails
ASER210-GLU219

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541
ChainResidueDetails
AGLY116
BGLY116

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER8
ASER9
BSER8
BSER9

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PDB entries from 2024-10-30

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