Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5JNC

Crystal structure for the complex of human carbonic anhydrase IV and 4-aminomethylbenzene sulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0005791	cellular_component	rough endoplasmic reticulum
A	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
A	0005794	cellular_component	Golgi apparatus
A	0005802	cellular_component	trans-Golgi network
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016829	molecular_function	lyase activity
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031526	cellular_component	brush border membrane
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070062	cellular_component	extracellular exosome
A	0098552	cellular_component	side of membrane
B	0004089	molecular_function	carbonate dehydratase activity
B	0005515	molecular_function	protein binding
B	0005791	cellular_component	rough endoplasmic reticulum
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005794	cellular_component	Golgi apparatus
B	0005802	cellular_component	trans-Golgi network
B	0005886	cellular_component	plasma membrane
B	0008270	molecular_function	zinc ion binding
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016829	molecular_function	lyase activity
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031526	cellular_component	brush border membrane
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070062	cellular_component	extracellular exosome
B	0098552	cellular_component	side of membrane
C	0004089	molecular_function	carbonate dehydratase activity
C	0005515	molecular_function	protein binding
C	0005791	cellular_component	rough endoplasmic reticulum
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005794	cellular_component	Golgi apparatus
C	0005802	cellular_component	trans-Golgi network
C	0005886	cellular_component	plasma membrane
C	0008270	molecular_function	zinc ion binding
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0015701	biological_process	bicarbonate transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0016324	cellular_component	apical plasma membrane
C	0016829	molecular_function	lyase activity
C	0030658	cellular_component	transport vesicle membrane
C	0030667	cellular_component	secretory granule membrane
C	0031526	cellular_component	brush border membrane
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0070062	cellular_component	extracellular exosome
C	0098552	cellular_component	side of membrane
D	0004089	molecular_function	carbonate dehydratase activity
D	0005515	molecular_function	protein binding
D	0005791	cellular_component	rough endoplasmic reticulum
D	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
D	0005794	cellular_component	Golgi apparatus
D	0005802	cellular_component	trans-Golgi network
D	0005886	cellular_component	plasma membrane
D	0008270	molecular_function	zinc ion binding
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0015701	biological_process	bicarbonate transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0016324	cellular_component	apical plasma membrane
D	0016829	molecular_function	lyase activity
D	0030658	cellular_component	transport vesicle membrane
D	0030667	cellular_component	secretory granule membrane
D	0031526	cellular_component	brush border membrane
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0070062	cellular_component	extracellular exosome
D	0098552	cellular_component	side of membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS94
A	HIS96
A	HIS119
A	6LH302

site_id	AC2
Number of Residues	10
Details	binding site for residue 6LH A 302

Chain	Residue
A	THR199
A	THR200
A	ZN301
A	HOH402
A	HOH572
A	GLN92
A	HIS94
A	HIS96
A	HIS119
A	LEU198

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 303

Chain	Residue
A	ARG27
A	LEU195
A	ARG254
A	THR255
A	HOH491
A	HOH502
A	HOH569

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 304

Chain	Residue
A	SER50
A	GLY50
A	TYR51
A	ASP52
A	LYS53
A	HOH548

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 305

Chain	Residue
A	GLN92
A	GLU123
A	HOH517

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 306

Chain	Residue
A	PHE48
A	SER50
A	SER78
A	ILE79
A	SER80
C	GLN60

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 307

Chain	Residue
A	ARG46
A	GLU187
C	ASN72
C	LYS91

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS94
B	HIS96
B	HIS119
B	6LH302

site_id	AC9
Number of Residues	10
Details	binding site for residue 6LH B 302

Chain	Residue
B	GLN92
B	HIS94
B	HIS96
B	HIS119
B	LEU198
B	THR199
B	THR200
B	TRP209
B	ZN301
B	HOH419

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG27
B	LEU195
B	ARG254
B	THR255
B	HOH410
B	HOH465

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 B 304

Chain	Residue
B	SER50
B	GLY50
B	TYR51
B	ASP52
B	LYS53
B	HOH402

site_id	AD3
Number of Residues	4
Details	binding site for residue ACT B 305

Chain	Residue
B	LYS15
D	GLU155
D	GLN158
D	GLU162

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL B 306

Chain	Residue
B	PHE48
B	SER78
B	ILE79
B	SER80
B	HOH423
B	HOH494
D	GLN60

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS94
C	HIS96
C	HIS119
C	6LH302

site_id	AD6
Number of Residues	8
Details	binding site for residue 6LH C 302

Chain	Residue
C	GLN92
C	HIS94
C	HIS96
C	HIS119
C	LEU198
C	THR199
C	THR200
C	ZN301

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG27
C	ARG254
C	THR255
C	HOH492

site_id	AD8
Number of Residues	6
Details	binding site for residue SO4 C 304

Chain	Residue
C	GLY50
C	TYR51
C	ASP52
C	LYS53
C	HOH514
C	HOH516

site_id	AD9
Number of Residues	4
Details	binding site for residue ACT C 305

Chain	Residue
A	ARG46
A	ARG189
C	ASN72
C	GLN89

site_id	AE1
Number of Residues	9
Details	binding site for residue GOL C 306

Chain	Residue
C	LYS103
C	ASP243
C	VAL245
C	PRO247
C	HOH415
C	HOH425
C	HOH445
C	HOH495
C	HOH507

site_id	AE2
Number of Residues	5
Details	binding site for residue GOL C 307

Chain	Residue
C	SER50
C	LYS53
C	ASN72
C	ALA77
C	SER78

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS94
D	HIS96
D	HIS119
D	6LH302

site_id	AE4
Number of Residues	11
Details	binding site for residue 6LH D 302

Chain	Residue
D	GLN92
D	HIS94
D	HIS96
D	HIS119
D	LEU198
D	THR199
D	THR200
D	TRP209
D	ZN301
D	HOH435
D	HOH500

site_id	AE5
Number of Residues	4
Details	binding site for residue SO4 D 303

Chain	Residue
D	ARG27
D	ARG254
D	THR255
D	HOH479

site_id	AE6
Number of Residues	6
Details	binding site for residue SO4 D 304

Chain	Residue
A	GLU2
D	GLY50
D	TYR51
D	ASP52
D	LYS53
D	HOH520

site_id	AE7
Number of Residues	9
Details	binding site for residue ACT D 305

Chain	Residue
D	SER98
D	ASP99
D	LEU100
D	PRO101
D	ALA115
D	ALA150
D	ILE223
D	LEU224
D	HOH433

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHsLdgehFamEMHIV

Chain	Residue	Details
A	SER105-VAL121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8942978","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"7625839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)