5JKL

Binary crystal structure of positively and negatively supercharged variants Ftn(pos) and Ftn(neg) from human heavy chain ferritin (Mg formate condition)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006880	biological_process	intracellular sequestering of iron ion
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006880	biological_process	intracellular sequestering of iron ion
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0070062	cellular_component	extracellular exosome
B	0070288	cellular_component	ferritin complex
B	0110076	biological_process	negative regulation of ferroptosis
B	0140315	molecular_function	iron ion sequestering activity
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006880	biological_process	intracellular sequestering of iron ion
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0070062	cellular_component	extracellular exosome
C	0070288	cellular_component	ferritin complex
C	0110076	biological_process	negative regulation of ferroptosis
C	0140315	molecular_function	iron ion sequestering activity
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006880	biological_process	intracellular sequestering of iron ion
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0048147	biological_process	negative regulation of fibroblast proliferation
D	0070062	cellular_component	extracellular exosome
D	0070288	cellular_component	ferritin complex
D	0110076	biological_process	negative regulation of ferroptosis
D	0140315	molecular_function	iron ion sequestering activity
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006880	biological_process	intracellular sequestering of iron ion
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0048147	biological_process	negative regulation of fibroblast proliferation
E	0070062	cellular_component	extracellular exosome
E	0070288	cellular_component	ferritin complex
E	0110076	biological_process	negative regulation of ferroptosis
E	0140315	molecular_function	iron ion sequestering activity
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006880	biological_process	intracellular sequestering of iron ion
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0070062	cellular_component	extracellular exosome
F	0070288	cellular_component	ferritin complex
F	0110076	biological_process	negative regulation of ferroptosis
F	0140315	molecular_function	iron ion sequestering activity
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006880	biological_process	intracellular sequestering of iron ion
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0048147	biological_process	negative regulation of fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0070288	cellular_component	ferritin complex
G	0110076	biological_process	negative regulation of ferroptosis
G	0140315	molecular_function	iron ion sequestering activity
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006880	biological_process	intracellular sequestering of iron ion
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0048147	biological_process	negative regulation of fibroblast proliferation
H	0070062	cellular_component	extracellular exosome
H	0070288	cellular_component	ferritin complex
H	0110076	biological_process	negative regulation of ferroptosis
H	0140315	molecular_function	iron ion sequestering activity
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006880	biological_process	intracellular sequestering of iron ion
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0042802	molecular_function	identical protein binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0048147	biological_process	negative regulation of fibroblast proliferation
I	0070062	cellular_component	extracellular exosome
I	0070288	cellular_component	ferritin complex
I	0110076	biological_process	negative regulation of ferroptosis
I	0140315	molecular_function	iron ion sequestering activity
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006880	biological_process	intracellular sequestering of iron ion
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0042802	molecular_function	identical protein binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0048147	biological_process	negative regulation of fibroblast proliferation
J	0070062	cellular_component	extracellular exosome
J	0070288	cellular_component	ferritin complex
J	0110076	biological_process	negative regulation of ferroptosis
J	0140315	molecular_function	iron ion sequestering activity
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006880	biological_process	intracellular sequestering of iron ion
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0042802	molecular_function	identical protein binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0048147	biological_process	negative regulation of fibroblast proliferation
K	0070062	cellular_component	extracellular exosome
K	0070288	cellular_component	ferritin complex
K	0110076	biological_process	negative regulation of ferroptosis
K	0140315	molecular_function	iron ion sequestering activity
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006880	biological_process	intracellular sequestering of iron ion
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0042802	molecular_function	identical protein binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0048147	biological_process	negative regulation of fibroblast proliferation
L	0070062	cellular_component	extracellular exosome
L	0070288	cellular_component	ferritin complex
L	0110076	biological_process	negative regulation of ferroptosis
L	0140315	molecular_function	iron ion sequestering activity
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FE A 201

Chain	Residue
A	GLU27
A	GLU62
A	HIS65
A	HOH304
A	HOH305

---

site_id	AC2
Number of Residues	8
Details	binding site for residue FE A 202

Chain	Residue
A	CL205
A	CL205
A	CL205
A	CL205
A	HIS173
A	HIS173
A	HIS173
A	HIS173

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 203

Chain	Residue
A	HOH335
A	HOH404
B	HOH348
B	HOH411
C	HOH341

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 204

Chain	Residue
A	GLN58
A	HOH308
A	HOH318
A	HOH327
A	HOH412

---

site_id	AC5
Number of Residues	8
Details	binding site for residue CL A 205

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173
A	FE202
A	FE202
A	FE202
A	FE202

---

site_id	AC6
Number of Residues	5
Details	binding site for residue FE B 201

Chain	Residue
B	GLU27
B	GLU62
B	HIS65
B	HOH312
B	HOH345

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MG B 202

Chain	Residue
B	GLN58
B	HOH301
B	HOH370

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL B 203

Chain	Residue
A	LYS71
B	TYR39
B	ASP42

---

site_id	AC9
Number of Residues	5
Details	binding site for residue FE C 201

Chain	Residue
C	GLU27
C	GLU62
C	HIS65
C	HOH313
C	HOH327

---

site_id	AD1
Number of Residues	5
Details	binding site for residue MG C 202

Chain	Residue
C	GLN58
C	GLU107
C	HOH303
C	HOH340
C	HOH421

---

site_id	AD2
Number of Residues	7
Details	binding site for residue GOL C 203

Chain	Residue
A	ASP131
A	GLU134
B	ASP131
B	THR135
C	ASP131
C	THR135
C	HOH305

---

site_id	AD3
Number of Residues	5
Details	binding site for residue FE D 201

Chain	Residue
D	GLU27
D	GLU62
D	HIS65
D	HOH314
D	HOH319

---

site_id	AD4
Number of Residues	5
Details	binding site for residue FE D 202

Chain	Residue
B	HIS173
C	HIS173
D	HIS173
D	CL205
E	HIS173

---

site_id	AD5
Number of Residues	7
Details	binding site for residue MG D 203

Chain	Residue
D	GLU134
D	HOH307
D	HOH419
E	HOH337
E	HOH400
F	HOH302
F	HOH409

---

site_id	AD6
Number of Residues	4
Details	binding site for residue MG D 204

Chain	Residue
D	GLN58
D	GLU61
D	HOH326
D	HOH375

---

site_id	AD7
Number of Residues	5
Details	binding site for residue CL D 205

Chain	Residue
B	HIS173
C	HIS173
D	HIS173
D	FE202
E	HIS173

---

site_id	AD8
Number of Residues	5
Details	binding site for residue FE E 201

Chain	Residue
E	GLU27
E	GLU62
E	HIS65
E	HOH314
E	HOH318

---

site_id	AD9
Number of Residues	8
Details	binding site for residue MG E 202

Chain	Residue
D	ASP131
D	HOH301
D	HOH313
E	ASP131
E	HOH317
F	ASP131
F	HOH304
F	HOH305

---

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL E 203

Chain	Residue
F	LYS87
L	GLU18
L	ASN21
L	ARG22
L	GLN83
E	ASP84

---

site_id	AE2
Number of Residues	5
Details	binding site for residue FE F 201

Chain	Residue
F	GLU27
F	GLU62
F	HIS65
F	HOH310
F	HOH313

---

site_id	AE3
Number of Residues	8
Details	binding site for residue FE F 202

Chain	Residue
F	HIS173
F	HIS173
F	HIS173
F	HIS173
F	CL204
F	CL204
F	CL204
F	CL204

---

site_id	AE4
Number of Residues	4
Details	binding site for residue MG F 203

Chain	Residue
F	GLN58
F	HOH318
F	HOH393
F	HOH415

---

site_id	AE5
Number of Residues	8
Details	binding site for residue CL F 204

Chain	Residue
F	HIS173
F	HIS173
F	HIS173
F	HIS173
F	FE202
F	FE202
F	FE202
F	FE202

---

site_id	AE6
Number of Residues	5
Details	binding site for residue FE G 201

Chain	Residue
G	GLU27
G	GLU62
G	HIS65
G	HOH305
G	HOH334

---

site_id	AE7
Number of Residues	8
Details	binding site for residue FE G 202

Chain	Residue
G	HIS173
G	HIS173
G	HIS173
G	HIS173
G	CL205
G	CL205
G	CL205
G	CL205

---

site_id	AE8
Number of Residues	8
Details	binding site for residue MG G 203

Chain	Residue
G	ASP131
G	HOH306
G	HOH308
H	ASP131
H	HOH302
H	HOH303
H	HOH307
I	ASP131

---

site_id	AE9
Number of Residues	6
Details	binding site for residue MG G 204

Chain	Residue
G	HOH366
G	HOH409
H	HOH306
H	HOH409
I	HOH334
I	HOH397

---

site_id	AF1
Number of Residues	8
Details	binding site for residue CL G 205

Chain	Residue
G	HIS173
G	HIS173
G	HIS173
G	HIS173
G	FE202
G	FE202
G	FE202
G	FE202

---

site_id	AF2
Number of Residues	5
Details	binding site for residue FE H 201

Chain	Residue
H	GLU27
H	GLU62
H	HIS65
H	HOH313
H	HOH347

---

site_id	AF3
Number of Residues	5
Details	binding site for residue FE H 202

Chain	Residue
H	HIS173
H	CL204
I	HIS173
J	HIS173
K	HIS173

---

site_id	AF4
Number of Residues	5
Details	binding site for residue MG H 203

Chain	Residue
H	GLN58
H	GLU61
H	HOH301
H	HOH304
H	HOH344

---

site_id	AF5
Number of Residues	5
Details	binding site for residue CL H 204

Chain	Residue
H	HIS173
H	FE202
I	HIS173
J	HIS173
K	HIS173

---

site_id	AF6
Number of Residues	6
Details	binding site for residue FE I 201

Chain	Residue
I	GLU27
I	GLU62
I	HIS65
I	HOH307
I	HOH317
I	HOH341

---

site_id	AF7
Number of Residues	5
Details	binding site for residue FE J 201

Chain	Residue
J	GLU27
J	GLU62
J	HIS65
J	HOH302
J	HOH317

---

site_id	AF8
Number of Residues	6
Details	binding site for residue MG J 202

Chain	Residue
J	HOH315
J	HOH392
K	HOH323
K	HOH390
L	HOH337
L	HOH385

---

site_id	AF9
Number of Residues	5
Details	binding site for residue FE K 201

Chain	Residue
K	GLU27
K	GLU62
K	HIS65
K	HOH310
K	HOH322

---

site_id	AG1
Number of Residues	4
Details	binding site for residue MG K 202

Chain	Residue
K	GLN58
K	GLU61
K	HOH301
K	HOH304

---

site_id	AG2
Number of Residues	5
Details	binding site for residue FE L 201

Chain	Residue
L	GLU27
L	GLU62
L	HIS65
L	HOH302
L	HOH317

---

site_id	AG3
Number of Residues	8
Details	binding site for residue FE L 202

Chain	Residue
L	HIS173
L	HIS173
L	HIS173
L	HIS173
L	CL204
L	CL204
L	CL204
L	CL204

---

site_id	AG4
Number of Residues	4
Details	binding site for residue MG L 203

Chain	Residue
L	GLN58
L	HOH316
L	HOH354
L	HOH390

---

site_id	AG5
Number of Residues	8
Details	binding site for residue CL L 204

Chain	Residue
L	HIS173
L	HIS173
L	HIS173
L	HIS173
L	FE202
L	FE202
L	FE202
L	FE202

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
G	ASP126-LYS146
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
G	GLU61-ARG79
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:1992356, ECO:0007744|PDB:1FHA

Chain	Residue	Details
G	GLU27
K	HIS65
L	GLU27
L	HIS65
G	HIS65
H	GLU27
H	HIS65
I	GLU27
I	HIS65
J	GLU27
J	HIS65
K	GLU27

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00085

Chain	Residue	Details
G	GLU62
J	GLU62
J	GLU107
J	GLN141
K	GLU62
K	GLU107
K	GLN141
L	GLU62
L	GLU107
L	GLN141
G	GLU107
G	GLN141
H	GLU62
H	GLU107
H	GLN141
I	GLU62
I	GLU107
I	GLN141

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269|PubMed:26436293

Chain	Residue	Details
G	ARG22
H	ARG22
I	ARG22
J	ARG22
K	ARG22
L	ARG22

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
G	MET0
H	MET0
I	MET0
J	MET0
K	MET0
L	MET0

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N-acetylthreonine; in Ferritin heavy chain, N-terminally processed => ECO:0007744|PubMed:22814378

Chain	Residue	Details
G	THR1
H	THR1
I	THR1
J	THR1
K	THR1
L	THR1

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
G	SER178
H	SER178
I	SER178
J	SER178
K	SER178
L	SER178

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18318008

Chain	Residue	Details
G	SER182
H	SER182
I	SER182
J	SER182
K	SER182
L	SER182

---