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5JK5

Phenylalanine hydroxylase from dictyostelium - BH2 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0004505molecular_functionphenylalanine 4-monooxygenase activity
A0004510molecular_functiontryptophan 5-monooxygenase activity
A0004664molecular_functionprephenate dehydratase activity
A0005506molecular_functioniron ion binding
A0005575cellular_componentcellular_component
A0006559biological_processL-phenylalanine catabolic process
A0006571biological_processtyrosine biosynthetic process
A0009072biological_processaromatic amino acid metabolic process
A0009094biological_processL-phenylalanine biosynthetic process
A0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
A0019954biological_processasexual reproduction
A0034617molecular_functiontetrahydrobiopterin binding
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
B0004497molecular_functionmonooxygenase activity
B0004505molecular_functionphenylalanine 4-monooxygenase activity
B0004510molecular_functiontryptophan 5-monooxygenase activity
B0004664molecular_functionprephenate dehydratase activity
B0005506molecular_functioniron ion binding
B0005575cellular_componentcellular_component
B0006559biological_processL-phenylalanine catabolic process
B0006571biological_processtyrosine biosynthetic process
B0009072biological_processaromatic amino acid metabolic process
B0009094biological_processL-phenylalanine biosynthetic process
B0016714molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B0019293biological_processtyrosine biosynthetic process, by oxidation of phenylalanine
B0019954biological_processasexual reproduction
B0034617molecular_functiontetrahydrobiopterin binding
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue FE A 501
ChainResidue
AHIS273
AHIS278
AGLU318
AHOH607
AHOH703
AHOH723

site_idAC2
Number of Residues7
Detailsbinding site for residue PIN A 502
ChainResidue
AASP289
AARG388
BASN403
BTYR405
ATHR226
AARG249
APRO285

site_idAC3
Number of Residues11
Detailsbinding site for residue HBI A 503
ChainResidue
AVAL233
AGLY235
ALEU236
ALEU237
APHE242
ASER310
ATYR313
AHOH607
AHOH650
AHOH703
AHOH764

site_idAC4
Number of Residues6
Detailsbinding site for residue FE B 501
ChainResidue
BHIS273
BHIS278
BGLU318
BHOH618
BHOH700
BHOH720

site_idAC5
Number of Residues12
Detailsbinding site for residue PIN B 502
ChainResidue
ALYS58
AASN403
ATYR405
BCYS225
BTHR226
BARG249
BPRO285
BASP289
BLYS384
BARG388
BHOH628
BHOH713

site_idAC6
Number of Residues12
Detailsbinding site for residue HBI B 503
ChainResidue
BVAL233
BGLY235
BLEU236
BLEU237
BALA239
BPHE242
BSER310
BTYR313
BHOH618
BHOH619
BHOH700
BHOH708

Functional Information from PROSITE/UniProt
site_idPS00367
Number of Residues12
DetailsBH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDccHELLGHVP
ChainResidueDetails
APRO269-PRO280

site_idPS00858
Number of Residues8
DetailsPREPHENATE_DEHYDR_2 Prephenate dehydratase signature 2. ITRIESRP
ChainResidueDetails
AILE49-PRO56

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS273
AHIS278
AGLU318
BHIS273
BHIS278
BGLU318

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PDB entries from 2024-06-19

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