5JJR

Dengue 3 NS5 protein with compound 29

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	mRNA (nucleoside-2'-O-)-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	GLU437
A	HIS441
A	CYS446
A	CYS449

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

---

site_id	AC3
Number of Residues	19
Details	binding site for residue SAH A 1003

Chain	Residue
A	GLY58
A	GLY81
A	CYS82
A	GLY83
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	HIS110
A	GLU111
A	LYS130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	HOH1115
A	HOH1149
A	HOH1427
A	SER56

---

site_id	AC4
Number of Residues	19
Details	binding site for residue 68E A 1004

Chain	Residue
A	MET340
A	LEU511
A	HIS512
A	CYS709
A	SER710
A	HIS711
A	ARG729
A	ARG737
A	MET761
A	MET765
A	THR794
A	SER796
A	HIS798
A	HIS800
A	GLN802
A	TRP803
A	HOH1139
A	HOH1216
A	HOH1296

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 1005

Chain	Residue
A	LYS14
A	LEU17
A	ASN18
A	PRO152

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG A 1006

Chain	Residue
A	ASP533
A	ASP664
A	HOH1130
A	HOH1143
A	HOH1221
A	HOH1263

---

site_id	AC7
Number of Residues	2
Details	binding site for residue EDO A 1007

Chain	Residue
A	ASN492
A	HOH1217

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PEG A 1008

Chain	Residue
A	LYS401
A	TRP477
A	ARG481
A	VAL603
A	EDO1009
A	HOH1217

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 1009

Chain	Residue
A	ASN452
A	GLY601
A	PEG1008
A	HOH1109

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PEG A 1010

Chain	Residue
A	GLY32
A	ILE33
A	ARG206
A	PRO208
A	LEU237
A	ARG241
A	HOH1153
A	HOH1285

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO A 1011

Chain	Residue
A	ARG499
A	LYS656
A	HOH1119
A	HOH1154

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 1012

Chain	Residue
A	VAL66
A	ASN69
A	ILE72
A	GLU296
A	EDO1013
A	HOH1138

---

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO A 1013

Chain	Residue
A	ILE72
A	LYS95
A	LYS96
A	ASN297
A	PRO298
A	EDO1012
A	HOH1147

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PEG A 1014

Chain	Residue
A	ARG57
A	GLU35
A	VAL36
A	ASP37
A	ARG38
A	THR39
A	LYS42

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: For 2'-O-MTase activity => ECO:0000269|PubMed:26578813

Chain	Residue	Details
A	LYS61
A	ASP146
A	LYS180
A	GLU216

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	SER56
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	ASP131
A	VAL132
A	ILE147
A	TYR218

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:17301146

Chain	Residue	Details
A	GLU437
A	HIS441
A	CYS446
A	CYS449
A	HIS712
A	CYS728
A	CYS847

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LYS14
A	ASN18
A	PHE25
A	LYS29
A	SER150
A	ARG211
A	SER213

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: mRNA cap binding; via carbonyl oxygen => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LEU17
A	LEU20

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Essential for 2'-O-methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	LYS61
A	LYS180
A	GLU216

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Essential for 2'-O-methyltransferase and N-7 methyltransferase activity => ECO:0000255|PROSITE-ProRule:PRU00924

Chain	Residue	Details
A	ASP146

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P03314

Chain	Residue	Details
A	SER56

---