5JEO

Phosphorylated Rotavirus NSP1 in complex with IRF-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PO4 A 501

Chain	Residue
A	ASP328
A	ARG338
A	PRO340
A	ARG341
A	HOH640

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site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 502

Chain	Residue
A	SER339
A	ARG211
A	ASP254
A	VAL257
A	ARG338

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site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 503

Chain	Residue
A	THR237
A	PRO239
A	ASP254
A	ARG255
A	GLY256
A	VAL257
A	GLY335
A	GLY337

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807

Chain	Residue	Details
A	THR237
A	THR244
A	THR253
A	THR404

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562

Chain	Residue	Details
A	SER385

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	SER386

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	SER396

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807

Chain	Residue	Details
A	SER398
A	SER427

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324

Chain	Residue	Details
A	LYS193
A	LYS360
A	LYS366

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