5JEO

Phosphorylated Rotavirus NSP1 in complex with IRF-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PO4 A 501

Chain	Residue
A	ASP328
A	ARG338
A	PRO340
A	ARG341
A	HOH640

---

site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 A 502

Chain	Residue
A	SER339
A	ARG211
A	ASP254
A	VAL257
A	ARG338

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PO4 A 503

Chain	Residue
A	THR237
A	PRO239
A	ASP254
A	ARG255
A	GLY256
A	VAL257
A	GLY335
A	GLY337

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Motif: {"description":"pLxIS motif","evidences":[{"source":"PubMed","id":"27302953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	Region: {"description":"Interaction with HERC5","evidences":[{"source":"PubMed","id":"20308324","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P70671","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39362857","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by TBK1","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27302953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39362857","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by IKKE and TBK1","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23478265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27302953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"20308324","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---