5JEM
Complex of IRF-3 with CBP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0003700 | molecular_function | DNA-binding transcription factor activity |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0000123 | cellular_component | histone acetyltransferase complex |
C | 0003713 | molecular_function | transcription coactivator activity |
C | 0004402 | molecular_function | histone acetyltransferase activity |
C | 0005634 | cellular_component | nucleus |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0000123 | cellular_component | histone acetyltransferase complex |
D | 0003713 | molecular_function | transcription coactivator activity |
D | 0004402 | molecular_function | histone acetyltransferase activity |
D | 0005634 | cellular_component | nucleus |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
E | 0003700 | molecular_function | DNA-binding transcription factor activity |
E | 0006355 | biological_process | regulation of DNA-templated transcription |
F | 0000123 | cellular_component | histone acetyltransferase complex |
F | 0003713 | molecular_function | transcription coactivator activity |
F | 0004402 | molecular_function | histone acetyltransferase activity |
F | 0005634 | cellular_component | nucleus |
F | 0006355 | biological_process | regulation of DNA-templated transcription |
G | 0003700 | molecular_function | DNA-binding transcription factor activity |
G | 0006355 | biological_process | regulation of DNA-templated transcription |
H | 0000123 | cellular_component | histone acetyltransferase complex |
H | 0003713 | molecular_function | transcription coactivator activity |
H | 0004402 | molecular_function | histone acetyltransferase activity |
H | 0005634 | cellular_component | nucleus |
H | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
C | SER2076 | |
G | THR237 | |
G | THR244 | |
G | THR253 | |
C | SER2079 | |
D | SER2076 | |
D | SER2079 | |
F | SER2076 | |
F | SER2079 | |
H | SER2076 | |
H | SER2079 | |
E | THR253 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P70671 |
Chain | Residue | Details |
A | LYS366 | |
B | LYS366 | |
E | LYS366 | |
G | LYS366 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562 |
Chain | Residue | Details |
A | SER385 | |
B | SER385 | |
E | SER385 | |
G | SER385 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
Chain | Residue | Details |
A | GLU386 | |
B | GLU386 | |
E | GLU386 | |
G | GLU386 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
Chain | Residue | Details |
A | GLU396 | |
B | GLU396 | |
E | GLU396 | |
G | GLU396 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
Chain | Residue | Details |
A | SER398 | |
B | SER398 | |
E | SER398 | |
G | SER398 |
site_id | SWS_FT_FI7 |
Number of Residues | 16 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324 |
Chain | Residue | Details |
A | LYS193 | |
E | LYS360 | |
E | LYS366 | |
G | LYS193 | |
G | LYS360 | |
G | LYS366 | |
A | LYS360 | |
A | LYS366 | |
B | LYS193 | |
B | LYS360 | |
B | LYS366 | |
E | LYS193 |