5JDG

Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 0.1mM Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005262	molecular_function	calcium channel activity
A	0005886	cellular_component	plasma membrane
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0008273	molecular_function	calcium, potassium:sodium antiporter activity
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 401

Chain	Residue
A	ALA47
A	THR50
A	SER51
A	GLU213
A	SER236

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 402

Chain	Residue
A	GLU213
A	THR50
A	SER51
A	GLU54
A	THR209

---

site_id	AC3
Number of Residues	6
Details	binding site for residue 1PE A 403

Chain	Residue
A	TYR17
A	SER20
A	MET215
A	LEU218
A	ALA219
A	LYS222

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PEG A 404

Chain	Residue
A	ARG140
A	ALA297

---

site_id	AC5
Number of Residues	5
Details	binding site for residue 1PE A 405

Chain	Residue
A	SER124
A	TRP125
A	SER249
A	MET252
A	HIS253

---

site_id	AC6
Number of Residues	1
Details	binding site for residue 1PE A 406

Chain	Residue
A	ARG282

---

site_id	AC7
Number of Residues	1
Details	binding site for residue 1PE A 407

Chain	Residue
A	ALA148

---

site_id	AC8
Number of Residues	7
Details	binding site for residue OLC A 408

Chain	Residue
A	SER37
A	ASN38
A	ASN224
A	LEU225
A	GLY226
A	GLY227
A	HOH512

---

site_id	AC9
Number of Residues	1
Details	binding site for residue OLC A 409

Chain	Residue
A	GLU180

---

site_id	AD1
Number of Residues	5
Details	binding site for residue OLC A 410

Chain	Residue
A	VAL117
A	ASP121
A	ASP127
A	MYS417
A	CA427

---

site_id	AD2
Number of Residues	2
Details	binding site for residue MYS A 411

Chain	Residue
A	GLN260
A	LEU299

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MYS A 412

Chain	Residue
A	ILE91
A	TRP125
A	LEU250
A	ILE286
A	ALA290

---

site_id	AD4
Number of Residues	3
Details	binding site for residue MYS A 413

Chain	Residue
A	VAL107
A	PHE114
A	LEU134

---

site_id	AD5
Number of Residues	3
Details	binding site for residue MYS A 414

Chain	Residue
A	LEU291
A	SER298
A	ARG300

---

site_id	AD6
Number of Residues	3
Details	binding site for residue MYS A 416

Chain	Residue
A	PHE9
A	PHE114
A	VAL117

---

site_id	AD7
Number of Residues	2
Details	binding site for residue MYS A 417

Chain	Residue
A	ASP127
A	OLC410

---

site_id	AD8
Number of Residues	1
Details	binding site for residue MYS A 418

Chain	Residue
A	TYR272

---

site_id	AD9
Number of Residues	1
Details	binding site for residue MYS A 419

Chain	Residue
A	ASN258

---

site_id	AE1
Number of Residues	3
Details	binding site for residue MYS A 420

Chain	Residue
A	VAL45
A	ILE48
A	VAL143

---

site_id	AE2
Number of Residues	2
Details	binding site for residue MYS A 421

Chain	Residue
A	LEU250
A	ARG282

---

site_id	AE3
Number of Residues	1
Details	binding site for residue MYS A 423

Chain	Residue
A	PHE274

---

site_id	AE4
Number of Residues	1
Details	binding site for residue MYS A 424

Chain	Residue
A	TYR60

---

site_id	AE5
Number of Residues	6
Details	binding site for residue CA A 427

Chain	Residue
A	ILE118
A	ASP121
A	GLY122
A	ASP127
A	OLC410
A	HOH525

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE3-PHE23
A	PHE39-ALA59
A	SER77-VAL97
A	LEU106-ILE126
A	GLY128-ALA148
A	PHE163-VAL183
A	VAL199-ALA219
A	GLY227-VAL247
A	LEU254-PHE274

---