5JB9
Crystal structure of factor IXa K98T variant in complex with PPACK
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 0G6 S 301 |
| Chain | Residue |
| S | ASP39 |
| S | SER214 |
| S | TRP215 |
| S | GLY216 |
| S | GLU219 |
| S | GLY226 |
| S | HOH417 |
| S | HOH428 |
| S | HOH515 |
| S | HOH534 |
| S | HOH550 |
| S | HIS57 |
| S | TYR99 |
| S | PHE174 |
| S | ASP189 |
| S | SER190 |
| S | GLN192 |
| S | GLY193 |
| S | SER195 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA S 302 |
| Chain | Residue |
| S | GLU70 |
| S | ASN72 |
| S | GLU75 |
| S | GLU77 |
| S | GLU80 |
| S | HOH430 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue DMS S 303 |
| Chain | Residue |
| S | ASP21 |
| S | ALA152 |
| S | LEU153 |
| S | HOH411 |
| S | HOH652 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| S | VAL53-CYS58 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPHV |
| Chain | Residue | Details |
| S | ASP189-VAL200 |
| site_id | PS01186 |
| Number of Residues | 16 |
| Details | EGF_2 EGF-like domain signature 2. CsCteGYrlaenqksC |
| Chain | Residue | Details |
| E | CYS109-CYS124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system => ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:659613 |
| Chain | Residue | Details |
| S | HIS57 | |
| S | SER195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Charge relay system => ECO:0000269|PubMed:659613 |
| Chain | Residue | Details |
| S | ASP102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:1RFN, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 |
| Chain | Residue | Details |
| S | GLU70 | |
| S | ASN72 | |
| S | GLU75 | |
| S | GLU77 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10467148, ECO:0000269|PubMed:20004170, ECO:0000269|PubMed:20080729, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0007744|PDB:2WPH, ECO:0007744|PDB:2WPI, ECO:0007744|PDB:2WPJ, ECO:0007744|PDB:2WPK, ECO:0007744|PDB:2WPM, ECO:0007744|PDB:3KCG, ECO:0007744|PDB:3LC3, ECO:0007744|PDB:3LC5 |
| Chain | Residue | Details |
| S | GLU80 |
