5J7F
Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| D | 0005634 | cellular_component | nucleus |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 6GG A 201 |
| Chain | Residue |
| A | VAL14 |
| A | HOH322 |
| D | MET62 |
| D | TYR67 |
| D | GLN72 |
| D | LYS94 |
| D | 6GG201 |
| A | LEU54 |
| A | GLY58 |
| A | ILE61 |
| A | MET62 |
| A | TYR67 |
| A | VAL93 |
| A | HIS96 |
| A | ILE99 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 6GG B 201 |
| Chain | Residue |
| B | VAL14 |
| B | THR16 |
| B | LEU54 |
| B | GLY58 |
| B | ILE61 |
| B | MET62 |
| B | TYR67 |
| B | VAL93 |
| B | HIS96 |
| C | TYR67 |
| C | GLN72 |
| C | 6GG201 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue 6GG C 201 |
| Chain | Residue |
| B | MET62 |
| B | TYR67 |
| B | GLN72 |
| B | VAL93 |
| B | 6GG201 |
| C | VAL14 |
| C | LEU54 |
| C | GLY58 |
| C | ILE61 |
| C | MET62 |
| C | TYR67 |
| C | VAL93 |
| C | HIS96 |
| C | HOH303 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue 6GG D 201 |
| Chain | Residue |
| A | MET62 |
| A | TYR67 |
| A | GLN72 |
| A | HIS96 |
| A | 6GG201 |
| D | VAL14 |
| D | LEU54 |
| D | PHE55 |
| D | GLY58 |
| D | ILE61 |
| D | MET62 |
| D | TYR67 |
| D | GLN72 |
| D | VAL93 |
| D | HIS96 |
