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5J6H

Recognition of the MHC class Ib molecule H2-Q10 by the natural killer cell receptor Ly49C

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0002376biological_processimmune system process
A0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
A0002476biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
A0002486biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
A0005102molecular_functionsignaling receptor binding
A0005615cellular_componentextracellular space
A0005765cellular_componentlysosomal membrane
A0005769cellular_componentearly endosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005797cellular_componentGolgi medial cisterna
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0030670cellular_componentphagocytic vesicle membrane
A0030881molecular_functionbeta-2-microglobulin binding
A0031901cellular_componentearly endosome membrane
A0032398cellular_componentMHC class Ib protein complex
A0033106cellular_componentcis-Golgi network membrane
A0042277molecular_functionpeptide binding
A0042288molecular_functionMHC class I protein binding
A0042605molecular_functionpeptide antigen binding
A0042608molecular_functionT cell receptor binding
A0042610molecular_functionCD8 receptor binding
A0042612cellular_componentMHC class I protein complex
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042824cellular_componentMHC class I peptide loading complex
A0044877molecular_functionprotein-containing complex binding
A0046703molecular_functionnatural killer cell lectin-like receptor binding
A0046977molecular_functionTAP binding
A0046978molecular_functionTAP1 binding
A0046979molecular_functionTAP2 binding
A0048018molecular_functionreceptor ligand activity
A0051087molecular_functionprotein-folding chaperone binding
A0062061molecular_functionTAP complex binding
A0070971cellular_componentendoplasmic reticulum exit site
A0071889molecular_function14-3-3 protein binding
A0098553cellular_componentlumenal side of endoplasmic reticulum membrane
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002477biological_processantigen processing and presentation of exogenous peptide antigen via MHC class Ib
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0003254biological_processregulation of membrane depolarization
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0006968biological_processcellular defense response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0010038biological_processresponse to metal ion
B0010977biological_processnegative regulation of neuron projection development
B0019731biological_processantibacterial humoral response
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031902cellular_componentlate endosome membrane
B0032398cellular_componentMHC class Ib protein complex
B0033077biological_processT cell differentiation in thymus
B0033572biological_processtransferrin transport
B0034756biological_processregulation of iron ion transport
B0034757biological_processnegative regulation of iron ion transport
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045087biological_processinnate immune response
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0071222biological_processcellular response to lipopolysaccharide
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue NA A 401
ChainResidue
ATHR94
AGLN96
AALA117
ATYR118
AASP119
AGLY120

site_idAC2
Number of Residues4
Detailsbinding site for residue NCA A 402
ChainResidue
BTYR94
APRO47
AARG48
AGLU53

site_idAC3
Number of Residues6
Detailsbinding site for residue NA B 101
ChainResidue
AALA236
AGLY237
BARG12
BILE22
BASN24
BHIS67

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH
ChainResidueDetails
BTYR78-HIS84
ATYR257-HIS263

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues89
DetailsRegion: {"description":"Alpha-1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues91
DetailsRegion: {"description":"Alpha-2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17330941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues89
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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