5J61

D-aminoacyl-tRNA deacylase (DTD) from Plasmodium falciparum in complex with glycyl-3'-aminoadenosine at 2.10 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0002161	molecular_function	aminoacyl-tRNA editing activity
A	0005737	cellular_component	cytoplasm
A	0006399	biological_process	tRNA metabolic process
A	0016787	molecular_function	hydrolase activity
A	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
A	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
A	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
A	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0002161	molecular_function	aminoacyl-tRNA editing activity
B	0005737	cellular_component	cytoplasm
B	0006399	biological_process	tRNA metabolic process
B	0016787	molecular_function	hydrolase activity
B	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
B	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
B	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
B	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0002161	molecular_function	aminoacyl-tRNA editing activity
C	0005737	cellular_component	cytoplasm
C	0006399	biological_process	tRNA metabolic process
C	0016787	molecular_function	hydrolase activity
C	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
C	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
C	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
C	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0002161	molecular_function	aminoacyl-tRNA editing activity
D	0005737	cellular_component	cytoplasm
D	0006399	biological_process	tRNA metabolic process
D	0016787	molecular_function	hydrolase activity
D	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
D	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
D	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
D	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
E	0000049	molecular_function	tRNA binding
E	0000166	molecular_function	nucleotide binding
E	0002161	molecular_function	aminoacyl-tRNA editing activity
E	0005737	cellular_component	cytoplasm
E	0006399	biological_process	tRNA metabolic process
E	0016787	molecular_function	hydrolase activity
E	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
E	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
E	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
E	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
F	0000049	molecular_function	tRNA binding
F	0000166	molecular_function	nucleotide binding
F	0002161	molecular_function	aminoacyl-tRNA editing activity
F	0005737	cellular_component	cytoplasm
F	0006399	biological_process	tRNA metabolic process
F	0016787	molecular_function	hydrolase activity
F	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
F	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
F	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
F	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
G	0000049	molecular_function	tRNA binding
G	0000166	molecular_function	nucleotide binding
G	0002161	molecular_function	aminoacyl-tRNA editing activity
G	0005737	cellular_component	cytoplasm
G	0006399	biological_process	tRNA metabolic process
G	0016787	molecular_function	hydrolase activity
G	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
G	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
G	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
G	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity
H	0000049	molecular_function	tRNA binding
H	0000166	molecular_function	nucleotide binding
H	0002161	molecular_function	aminoacyl-tRNA editing activity
H	0005737	cellular_component	cytoplasm
H	0006399	biological_process	tRNA metabolic process
H	0016787	molecular_function	hydrolase activity
H	0051499	molecular_function	D-aminoacyl-tRNA deacylase activity
H	0051500	molecular_function	D-tyrosyl-tRNA(Tyr) deacylase activity
H	0106026	molecular_function	Gly-tRNA(Ala) hydrolase activity
H	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue A3G A 501

Chain	Residue
A	LEU41
A	ILE43
A	SER87
A	GLN88
A	PHE89
A	LYS107
A	PHE137
A	GLY138
B	PRO150

---

site_id	AC2
Number of Residues	10
Details	binding site for residue A3G B 501

Chain	Residue
A	GLY149
A	PRO150
B	LEU41
B	ILE43
B	SER87
B	GLN88
B	PHE89
B	LYS107
B	PHE137
B	GLY138

---

site_id	AC3
Number of Residues	10
Details	binding site for residue A3G C 501

Chain	Residue
C	LEU41
C	ILE43
C	SER87
C	GLN88
C	PHE89
C	LYS107
C	PHE137
C	GLY138
D	GLY149
D	PRO150

---

site_id	AC4
Number of Residues	9
Details	binding site for residue A3G D 501

Chain	Residue
C	PRO150
D	LEU41
D	ILE43
D	SER87
D	GLN88
D	PHE89
D	LYS107
D	PHE137
D	GLY138

---

site_id	AC5
Number of Residues	11
Details	binding site for residue A3G E 501

Chain	Residue
C	GLU108
C	ASN110
E	LEU41
E	ILE43
E	SER87
E	GLN88
E	PHE89
E	LYS107
E	PHE137
E	GLY138
F	PRO150

---

site_id	AC6
Number of Residues	12
Details	binding site for residue A3G F 501

Chain	Residue
E	PRO150
F	LEU41
F	ILE43
F	SER87
F	GLN88
F	PHE89
F	LYS107
F	PRO109
F	ALA112
F	PHE137
F	GLY138
F	HOH604

---

site_id	AC7
Number of Residues	10
Details	binding site for residue A3G G 501

Chain	Residue
G	LEU41
G	ILE43
G	SER87
G	GLN88
G	PHE89
G	LYS107
G	PHE137
G	GLY138
G	HOH602
H	PRO150

---

site_id	AC8
Number of Residues	9
Details	binding site for residue A3G H 501

Chain	Residue
G	PRO150
H	LEU41
H	ILE43
H	SER87
H	GLN88
H	PHE89
H	LYS107
H	PHE137
H	GLY138

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:20007323

Chain	Residue	Details
A	THR90
B	THR90
C	THR90
D	THR90
E	THR90
F	THR90
G	THR90
H	THR90

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:20007323, ECO:0007744|PDB:3KO5

Chain	Residue	Details
A	TRP72
B	TRP72
C	TRP72
D	TRP72
E	TRP72
F	TRP72
G	TRP72
H	TRP72

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:20007323, ECO:0007744|PDB:3KO4, ECO:0007744|PDB:3KO5

Chain	Residue	Details
A	PHE89
B	PHE89
C	PHE89
D	PHE89
E	PHE89
F	PHE89
G	PHE89
H	PHE89

---