5J60

Structure of a thioredoxin reductase from Gloeobacter violaceus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0016491	molecular_function	oxidoreductase activity
A	0045454	biological_process	cell redox homeostasis
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000166	molecular_function	nucleotide binding
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0016491	molecular_function	oxidoreductase activity
B	0045454	biological_process	cell redox homeostasis
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0000166	molecular_function	nucleotide binding
C	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
C	0016491	molecular_function	oxidoreductase activity
C	0045454	biological_process	cell redox homeostasis
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0000166	molecular_function	nucleotide binding
D	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
D	0016491	molecular_function	oxidoreductase activity
D	0045454	biological_process	cell redox homeostasis
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	37
Details	binding site for residue FAD A 401

Chain	Residue
A	GLY12
A	ALA42
A	LEU43
A	THR46
A	ILE49
A	ASN51
A	ALA82
A	VAL84
A	THR112
A	GLY113
A	GLY277
A	GLY14
A	ASP278
A	LYS285
A	GLN286
A	ALA287
A	ALA290
A	HOH520
A	HOH536
A	HOH550
A	HOH553
A	HOH564
A	PRO15
A	HOH572
A	HOH586
A	HOH599
A	HOH617
A	HOH631
D	ASP314
D	TRP315
D	ALA316
A	ALA16
A	LEU34
A	ASP35
A	LYS36
A	ASN37
A	GLY41

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 402

Chain	Residue
A	GLU264
A	PG4403
D	GLU264

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site_id	AC3
Number of Residues	7
Details	binding site for residue PG4 A 403

Chain	Residue
A	VAL262
A	ASP263
A	GLU264
A	CA402
D	VAL262
D	ASP263
D	GLU264

---

site_id	AC4
Number of Residues	39
Details	binding site for residue FAD B 500

Chain	Residue
B	GLY12
B	GLY13
B	GLY14
B	PRO15
B	ALA16
B	LEU34
B	ASP35
B	LYS36
B	ASN37
B	GLY41
B	ALA42
B	LEU43
B	THR46
B	ILE49
B	ASN51
B	ALA82
B	VAL84
B	ALA111
B	THR112
B	GLY113
B	GLY277
B	ASP278
B	LYS285
B	GLN286
B	ALA287
B	ALA290
B	HOH628
B	HOH638
B	HOH640
B	HOH659
B	HOH660
B	HOH674
B	HOH682
B	HOH714
B	HOH715
C	TYR23
C	ASP314
C	TRP315
C	ALA316

---

site_id	AC5
Number of Residues	9
Details	binding site for residue PG4 B 501

Chain	Residue
B	VAL262
B	ASP263
B	GLU264
B	CA502
C	VAL262
C	ASP263
C	GLU264
C	MET266
C	ARG280

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CA B 502

Chain	Residue
B	GLU264
B	PG4501
C	GLU264

---

site_id	AC7
Number of Residues	38
Details	binding site for residue FAD C 500

Chain	Residue
B	TRP315
B	ALA316
C	GLY12
C	GLY13
C	GLY14
C	PRO15
C	ALA16
C	LEU34
C	ASP35
C	LYS36
C	ASN37
C	GLY41
C	ALA42
C	LEU43
C	THR46
C	ILE49
C	ASN51
C	ALA82
C	VAL84
C	ALA111
C	THR112
C	GLY113
C	GLY277
C	ASP278
C	LYS285
C	GLN286
C	ALA287
C	ALA290
C	HOH607
C	HOH635
C	HOH637
C	HOH640
C	HOH643
C	HOH656
C	HOH657
C	HOH673
C	HOH677
B	ASP314

---

site_id	AC8
Number of Residues	39
Details	binding site for residue FAD D 401

Chain	Residue
A	ASP314
A	TRP315
A	ALA316
D	GLY12
D	GLY13
D	GLY14
D	PRO15
D	ALA16
D	LEU34
D	ASP35
D	LYS36
D	ASN37
D	GLY41
D	ALA42
D	LEU43
D	THR46
D	ILE49
D	ASN51
D	ALA82
D	VAL84
D	ALA111
D	THR112
D	GLY113
D	ILE244
D	GLY277
D	ASP278
D	LYS285
D	GLN286
D	ALA287
D	ALA290
D	HOH604
D	HOH630
D	HOH642
D	HOH649
D	HOH651
D	HOH653
D	HOH672
D	HOH675
D	HOH679

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