Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AA | 0046872 | molecular_function | metal ion binding |
| AB | 0004222 | molecular_function | metalloendopeptidase activity |
| AB | 0006508 | biological_process | proteolysis |
| AB | 0046872 | molecular_function | metal ion binding |
| AC | 0005743 | cellular_component | mitochondrial inner membrane |
| AC | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AC | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AC | 0009055 | molecular_function | electron transfer activity |
| AC | 0016020 | cellular_component | membrane |
| AC | 0016491 | molecular_function | oxidoreductase activity |
| AC | 0022904 | biological_process | respiratory electron transport chain |
| AC | 0045275 | cellular_component | respiratory chain complex III |
| AC | 0046872 | molecular_function | metal ion binding |
| AC | 1902600 | biological_process | proton transmembrane transport |
| AD | 0009055 | molecular_function | electron transfer activity |
| AD | 0020037 | molecular_function | heme binding |
| AE | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AE | 0016020 | cellular_component | membrane |
| AE | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| AF | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AF | 0045275 | cellular_component | respiratory chain complex III |
| AG | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AG | 0045275 | cellular_component | respiratory chain complex III |
| AH | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AI | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AJ | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AJ | 0045275 | cellular_component | respiratory chain complex III |
| AK | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AL | 0046872 | molecular_function | metal ion binding |
| AM | 0004222 | molecular_function | metalloendopeptidase activity |
| AM | 0006508 | biological_process | proteolysis |
| AM | 0046872 | molecular_function | metal ion binding |
| AN | 0005743 | cellular_component | mitochondrial inner membrane |
| AN | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AN | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AN | 0009055 | molecular_function | electron transfer activity |
| AN | 0016020 | cellular_component | membrane |
| AN | 0016491 | molecular_function | oxidoreductase activity |
| AN | 0022904 | biological_process | respiratory electron transport chain |
| AN | 0045275 | cellular_component | respiratory chain complex III |
| AN | 0046872 | molecular_function | metal ion binding |
| AN | 1902600 | biological_process | proton transmembrane transport |
| AO | 0009055 | molecular_function | electron transfer activity |
| AO | 0020037 | molecular_function | heme binding |
| AP | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AP | 0016020 | cellular_component | membrane |
| AP | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| AQ | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AQ | 0045275 | cellular_component | respiratory chain complex III |
| AR | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AR | 0045275 | cellular_component | respiratory chain complex III |
| AS | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AT | 0008121 | molecular_function | quinol-cytochrome-c reductase activity |
| AU | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| AU | 0045275 | cellular_component | respiratory chain complex III |
| AV | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| BC | 0004129 | molecular_function | cytochrome-c oxidase activity |
| BC | 0005739 | cellular_component | mitochondrion |
| BC | 0005743 | cellular_component | mitochondrial inner membrane |
| BC | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BC | 0008535 | biological_process | respiratory chain complex IV assembly |
| BC | 0009055 | molecular_function | electron transfer activity |
| BC | 0009060 | biological_process | aerobic respiration |
| BC | 0016020 | cellular_component | membrane |
| BC | 0019646 | biological_process | aerobic electron transport chain |
| BC | 0022904 | biological_process | respiratory electron transport chain |
| BC | 0031966 | cellular_component | mitochondrial membrane |
| BC | 0045277 | cellular_component | respiratory chain complex IV |
| BC | 1902600 | biological_process | proton transmembrane transport |
| BD | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BD | 0045277 | cellular_component | respiratory chain complex IV |
| BE | 0005743 | cellular_component | mitochondrial inner membrane |
| BE | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BE | 0045277 | cellular_component | respiratory chain complex IV |
| BG | 0005743 | cellular_component | mitochondrial inner membrane |
| BH | 0005739 | cellular_component | mitochondrion |
| BH | 0045277 | cellular_component | respiratory chain complex IV |
| BJ | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BJ | 0045277 | cellular_component | respiratory chain complex IV |
| BK | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BL | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BL | 0045277 | cellular_component | respiratory chain complex IV |
| BM | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BM | 0045277 | cellular_component | respiratory chain complex IV |
| BN | 0004129 | molecular_function | cytochrome-c oxidase activity |
| BN | 0005739 | cellular_component | mitochondrion |
| BN | 0005743 | cellular_component | mitochondrial inner membrane |
| BN | 0006119 | biological_process | oxidative phosphorylation |
| BN | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BN | 0009060 | biological_process | aerobic respiration |
| BN | 0015990 | biological_process | electron transport coupled proton transport |
| BN | 0016020 | cellular_component | membrane |
| BN | 0020037 | molecular_function | heme binding |
| BN | 0022904 | biological_process | respiratory electron transport chain |
| BN | 0031966 | cellular_component | mitochondrial membrane |
| BN | 0045277 | cellular_component | respiratory chain complex IV |
| BN | 0046872 | molecular_function | metal ion binding |
| BO | 0004129 | molecular_function | cytochrome-c oxidase activity |
| BO | 0005507 | molecular_function | copper ion binding |
| BO | 0005739 | cellular_component | mitochondrion |
| BO | 0005743 | cellular_component | mitochondrial inner membrane |
| BO | 0016020 | cellular_component | membrane |
| BO | 0016491 | molecular_function | oxidoreductase activity |
| BO | 0017004 | biological_process | cytochrome complex assembly |
| BO | 0022900 | biological_process | electron transport chain |
| BO | 0022904 | biological_process | respiratory electron transport chain |
| BO | 0031966 | cellular_component | mitochondrial membrane |
| BO | 0042773 | biological_process | ATP synthesis coupled electron transport |
| BO | 0045277 | cellular_component | respiratory chain complex IV |
| BO | 0046872 | molecular_function | metal ion binding |
| BO | 1902600 | biological_process | proton transmembrane transport |
| BP | 0005740 | cellular_component | mitochondrial envelope |
| BP | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| BP | 0045277 | cellular_component | respiratory chain complex IV |
| G | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
| Chain | Residue | Details |
| BN | TRP236-HIS291 |
| site_id | PS00143 |
| Number of Residues | 24 |
| Details | INSULINASE Insulinase family, zinc-binding region signature. GsryenfnnlGtSHLLRLAsSlTT |
| Chain | Residue | Details |
| AB | GLY54-THR77 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
| Chain | Residue | Details |
| BP | VAL69-LEU91 |
| site_id | PS01329 |
| Number of Residues | 18 |
| Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
| Chain | Residue | Details |
| BG | ILE55-ASN72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 322 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 110 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27654913","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 269 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27654913","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 35 |
| Details | Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=III","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=V","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 33 |
| Details | Transmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=VIII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=IX","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=X","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=XI","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 31 |
| Details | Transmembrane: {"description":"Helical; Name=XII","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"27654913","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27654913","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"UniProtKB","id":"P68530","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"UniProtKB","id":"P68530","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P68530","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P00406","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=III","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=V","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"UniProtKB","id":"P00415","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
