5J3T
Crystal structure of S. pombe Dcp2:Dcp1:Edc1 mRNA decapping complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0000932 | cellular_component | P-body |
| A | 0000956 | biological_process | nuclear-transcribed mRNA catabolic process |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0043085 | biological_process | positive regulation of catalytic activity |
| A | 0043229 | cellular_component | intracellular organelle |
| A | 0098745 | cellular_component | RNA decapping complex |
| A | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| A | 0170008 | molecular_function | mRNA phosphatase activator activity |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0003723 | molecular_function | RNA binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 201 |
| Chain | Residue |
| A | SER31 |
| A | HIS32 |
| A | THR53 |
| A | ARG71 |
| A | HOH319 |
| B | ASN22 |
| B | LEU23 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue FMT A 202 |
| Chain | Residue |
| A | ASN82 |
| A | HIS83 |
| A | ASN86 |
| A | HIS96 |
| A | ARG97 |
| A | ASN119 |
| A | PHE80 |
| A | ILE81 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 301 |
| Chain | Residue |
| B | GLY124 |
| B | PHE125 |
| B | LYS127 |
| B | MET221 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 302 |
| Chain | Residue |
| A | ARG92 |
| B | ASN157 |
| B | GLU160 |
| B | HOH486 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 303 |
| Chain | Residue |
| B | ARG91 |
| B | TYR92 |
| B | GLN109 |
| B | LYS195 |
| B | ILE196 |
| B | GLU197 |
| B | HOH439 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 304 |
| Chain | Residue |
| B | TYR92 |
| B | PHE185 |
| B | HOH429 |
| B | HOH439 |
| B | HOH463 |
| B | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GkidkdEsdvdCAiREVyEEtG |
| Chain | Residue | Details |
| B | GLY128-GLY149 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | ARG167 | |
| B | TYR220 |
