5J32
Isopropylmalate dehydrogenase in complex with isopropylmalate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0009507 | cellular_component | chloroplast |
| A | 0009536 | cellular_component | plastid |
| A | 0009553 | biological_process | embryo sac development |
| A | 0009555 | biological_process | pollen development |
| A | 0009570 | cellular_component | chloroplast stroma |
| A | 0009941 | cellular_component | chloroplast envelope |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0009507 | cellular_component | chloroplast |
| B | 0009536 | cellular_component | plastid |
| B | 0009553 | biological_process | embryo sac development |
| B | 0009555 | biological_process | pollen development |
| B | 0009570 | cellular_component | chloroplast stroma |
| B | 0009941 | cellular_component | chloroplast envelope |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009098 | biological_process | L-leucine biosynthetic process |
| C | 0009507 | cellular_component | chloroplast |
| C | 0009536 | cellular_component | plastid |
| C | 0009553 | biological_process | embryo sac development |
| C | 0009555 | biological_process | pollen development |
| C | 0009570 | cellular_component | chloroplast stroma |
| C | 0009941 | cellular_component | chloroplast envelope |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070403 | molecular_function | NAD+ binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009098 | biological_process | L-leucine biosynthetic process |
| D | 0009507 | cellular_component | chloroplast |
| D | 0009536 | cellular_component | plastid |
| D | 0009553 | biological_process | embryo sac development |
| D | 0009555 | biological_process | pollen development |
| D | 0009570 | cellular_component | chloroplast stroma |
| D | 0009941 | cellular_component | chloroplast envelope |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | ASP288 |
| A | ASP292 |
| A | IPM502 |
| A | HOH623 |
| A | HOH657 |
| B | ASP264 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue IPM A 502 |
| Chain | Residue |
| A | TYR181 |
| A | ASP288 |
| A | MG501 |
| A | HOH623 |
| A | HOH657 |
| A | HOH785 |
| B | LYS232 |
| B | ASP264 |
| A | ARG136 |
| A | ARG146 |
| A | ARG174 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | ASP264 |
| A | IPM504 |
| B | ASP288 |
| B | ASP292 |
| B | HOH654 |
| B | HOH655 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue IPM A 504 |
| Chain | Residue |
| A | LYS232 |
| A | ASN234 |
| A | VAL235 |
| A | ASP264 |
| A | MG503 |
| A | HOH793 |
| B | ARG136 |
| B | ARG146 |
| B | ARG174 |
| B | TYR181 |
| B | ASP288 |
| B | HOH654 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 501 |
| Chain | Residue |
| C | ASP288 |
| C | ASP292 |
| C | IPM502 |
| C | HOH622 |
| C | HOH803 |
| D | ASP264 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue IPM C 502 |
| Chain | Residue |
| C | ARG136 |
| C | ARG146 |
| C | ARG174 |
| C | TYR181 |
| C | ASP288 |
| C | MG501 |
| C | HOH622 |
| C | HOH773 |
| D | LYS232 |
| D | ASP264 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 503 |
| Chain | Residue |
| C | ASP264 |
| C | IPM504 |
| C | HOH625 |
| D | ASP288 |
| D | ASP292 |
| D | HOH799 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue IPM C 504 |
| Chain | Residue |
| C | LYS232 |
| C | ASP264 |
| C | MG503 |
| C | HOH625 |
| D | ARG136 |
| D | ARG146 |
| D | ARG174 |
| D | TYR181 |
| D | ASP288 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIlSDeaSmit.GSIGM |
| Chain | Residue | Details |
| A | ASN284-MET303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27137927","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J33","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27137927","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J32","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27137927","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5J32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J34","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Confers substrate specificity","evidences":[{"source":"PubMed","id":"21697089","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Important for catalysis","evidences":[{"source":"PubMed","id":"27137927","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Essential for redox regulation","evidences":[{"source":"UniProtKB","id":"Q9FMT1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9FMT1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
