5J1S
TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000338 | biological_process | protein deneddylation |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0006457 | biological_process | protein folding |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0006998 | biological_process | nuclear envelope organization |
| A | 0007155 | biological_process | cell adhesion |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0019894 | molecular_function | kinesin binding |
| A | 0030133 | cellular_component | transport vesicle |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030426 | cellular_component | growth cone |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031175 | biological_process | neuron projection development |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0034504 | biological_process | protein localization to nucleus |
| A | 0036503 | biological_process | ERAD pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044319 | biological_process | wound healing, spreading of cells |
| A | 0045104 | biological_process | intermediate filament cytoskeleton organization |
| A | 0048489 | biological_process | synaptic vesicle transport |
| A | 0048499 | biological_process | synaptic vesicle membrane organization |
| A | 0051082 | molecular_function | unfolded protein binding |
| A | 0051584 | biological_process | regulation of dopamine uptake involved in synaptic transmission |
| A | 0051787 | molecular_function | misfolded protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071763 | biological_process | nuclear membrane organization |
| A | 0140662 | molecular_function | ATP-dependent protein folding chaperone |
| A | 1900244 | biological_process | positive regulation of synaptic vesicle endocytosis |
| A | 2000008 | biological_process | regulation of protein localization to cell surface |
| B | 0001671 | molecular_function | ATPase activator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue ATP A 401 |
| Chain | Residue |
| A | ASN68 |
| A | PHE110 |
| A | GLN171 |
| A | ASN208 |
| A | CYS280 |
| A | CYS319 |
| A | LYS320 |
| A | MG402 |
| A | HOH546 |
| A | HOH547 |
| A | HOH562 |
| A | LEU69 |
| A | HOH578 |
| A | HOH612 |
| A | HOH641 |
| A | HOH649 |
| B | HIS384 |
| B | ARG449 |
| A | PHE70 |
| A | THR104 |
| A | GLY105 |
| A | THR106 |
| A | GLY107 |
| A | LYS108 |
| A | ASN109 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASN109 |
| A | ATP401 |
| A | HOH546 |
| A | HOH547 |
| A | HOH562 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | ASN143 |
| A | TYR147 |
| C | ASN33 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MES A 404 |
| Chain | Residue |
| A | ASP64 |
| A | ASN68 |
| A | PHE110 |
| A | LYS113 |
| A | ILE114 |
| A | GLU117 |
| A | HOH580 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | THR320 |
| B | GLN323 |
| B | VAL325 |
| B | HOH613 |
| B | HOH757 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 201 |
| Chain | Residue |
| B | THR342 |
| B | HOH800 |
| C | THR58 |
| C | HOH362 |
| C | HOH373 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Region: {"description":"Interaction with SNAPIN"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PubMed","id":"10871631","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 234 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 234 |
| Details | Region: {"description":"Interaction with TOR1A","evidences":[{"source":"PubMed","id":"23569223","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
