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5IWM

2.5A structure of GSK945237 with S.aureus DNA gyrase and DNA.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A0005524molecular_functionATP binding
A0006259biological_processDNA metabolic process
A0006265biological_processDNA topological change
B0003677molecular_functionDNA binding
B0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B0005524molecular_functionATP binding
B0006265biological_processDNA topological change
C0003677molecular_functionDNA binding
C0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C0005524molecular_functionATP binding
C0006259biological_processDNA metabolic process
C0006265biological_processDNA topological change
D0003677molecular_functionDNA binding
D0003918molecular_functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D0005524molecular_functionATP binding
D0006265biological_processDNA topological change
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue MN B 701
ChainResidue
BGLU435
BASP508
BHOH803
BHOH814
EDG8
EDG9
FDT8
FDG9

site_idAC2
Number of Residues8
Detailsbinding site for residue MN D 1001
ChainResidue
DASP508
DHOH1106
DHOH1121
EDG8
EDG9
FDT8
FDG9
DGLU435

site_idAC3
Number of Residues5
Detailsbinding site for residue GOL C 501
ChainResidue
CPRO44
CARG47
CARG48
CGLU156
CHOH647

site_idAC4
Number of Residues14
Detailsbinding site for residue 6EJ F 101
ChainResidue
AALA68
AMET75
AASP83
AMET121
CALA68
CMET75
CASP83
CMET121
EDT10
EDT11
FDA10
FDA11
FHOH212
FHOH219

Functional Information from PROSITE/UniProt
site_idPS00177
Number of Residues9
DetailsTOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG
ChainResidueDetails
BLEU433-GLY441

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897
ChainResidueDetails
APHE123
CPHE123
BASP510
DGLU435
DASP508
DASP510

site_idSWS_FT_FI2
Number of Residues4
DetailsSITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898
ChainResidueDetails
BLYS460
BASN463
DLYS460
DASN463

223532

PDB entries from 2024-08-07

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