Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006265 | biological_process | DNA topological change |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0006265 | biological_process | DNA topological change |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MN B 701 |
| Chain | Residue |
| B | GLU435 |
| B | ASP508 |
| B | HOH803 |
| B | HOH814 |
| E | DG8 |
| E | DG9 |
| F | DT8 |
| F | DG9 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MN D 1001 |
| Chain | Residue |
| D | ASP508 |
| D | HOH1106 |
| D | HOH1121 |
| E | DG8 |
| E | DG9 |
| F | DT8 |
| F | DG9 |
| D | GLU435 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| C | PRO44 |
| C | ARG47 |
| C | ARG48 |
| C | GLU156 |
| C | HOH647 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 6EJ F 101 |
| Chain | Residue |
| A | ALA68 |
| A | MET75 |
| A | ASP83 |
| A | MET121 |
| C | ALA68 |
| C | MET75 |
| C | ASP83 |
| C | MET121 |
| E | DT10 |
| E | DT11 |
| F | DA10 |
| F | DA11 |
| F | HOH212 |
| F | HOH219 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| B | LEU433-GLY441 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]} |
